Therapy of Fabry disease with pharmacological chaperones: from in silico predictions to in vitro tests [PDF]
, 2011 Background: Fabry disease is a rare disorder caused by a large variety of mutations in the gene encoding lysosomal alpha-galactosidase. Many of these mutations are unique to individual families.
Giuseppina Andreotti +6 more
core +2 more sources
Viral Membrane Channels: Role and Function in the Virus Life Cycle [PDF]
, 2015 10.3390/v7062771Viruses763261 ...
Aldabe +33 more
core +2 more sources
The p7 protein of the hepatitis C virus induces cell death differently from the influenza A virus viroporin M2 [PDF]
, 2013 10.1016/j.virusres.2012.12.005Virus Research 1721-224 ...
Aweya, Jude Juventus +3 more
core +1 more source
The Iminosugar UV-4 is a Broad Inhibitor of Influenza A and B Viruses ex Vivo and in Mice
Viruses, 2016 Iminosugars that are competitive inhibitors of endoplasmic reticulum (ER) α-glucosidases have been demonstrated to have antiviral activity against a diverse set of viruses.
Kelly L. Warfield +8 more
doaj +1 more source
Unravelling the Specificity of Laminaribiose Phosphorylase from Paenibacillus sp. YM‐1 towards Donor Substrates Glucose/Mannose 1‐Phosphate by Using X‐ray Crystallography and Saturation Transfer Difference NMR Spectroscopy [PDF]
, 2018 Glycoside phosphorylases (GPs) carry out a reversible phosphorolysis of carbohydrates into oligosaccharide acceptors and the corresponding sugar 1‐phosphates.
Angulo, Jesus +6 more
core +1 more source
Viroporins: A new target for fighting viral infections [PDF]
, 2017 Over the last years an increasing number of viruses have jumped into the mass media and several names or acronyms (Ebola, zika, SARS, MERS,…) have become familiar to the general public because of the high mortality rates associated with their infection ...
Aguilella, Vicente
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Adenylyl Cyclase Type 8 Overexpression Impairs Phosphorylation-Dependent Orai1 Inactivation and Promotes Migration in MDA-MB-231 Breast Cancer Cells. [PDF]
, 2019 Orai1 plays a major role in store-operated Ca 2+ entry (SOCE) in triple-negative breast cancer (TNBC) cells. This channel is inactivated via different mechanisms, including protein kinase C (PKC) and protein kinase A (PKA)-dependent phosphorylation at ...
Falcón Boyano, Débora +1 more
core
The synthesis of tetrafluorinated aminosugars
, 2014 The synthesis of two tetrafluorinated 4-aminosugars, 4-amino-2,3,4-trideoxy-2,2,3,3-tetrafluoro-d-erythro-hexopyranose hydrochloride (7•HCl) and 4-amino-2,3,4-trideoxy-2,2,3,3-tetrafluoro-d-threo-hexopyranose hydrochloride (8•HCl), is described.
Fontenelle, Clément Q. +2 more
core +1 more source
Ambroxol effects in glucocerebrosidase and -synuclein transgenic mice [PDF]
, 2016 Objective. Gaucher disease is caused by mutations in the glucocerebrosidase 1 gene that result in deficiency of the lysosomal enzyme glucocerebrosidase.
Bezard, E +3 more
core
Expression and function of osteopontin variants in HCV-related liver disease and hepatocellular carcinoma. [PDF]
, 2010 Osteopontin (OPN) is a highly secreted multi-functional sialoprotein that is widely expressed in tissues, blood and urine. It is involved in a number of normal physiological functions, but is also significantly elevated in a number of cancers.
Phillips, Renee Jade
core +1 more source