Results 51 to 60 of about 2,892 (197)

Selective Targeting of the Interconversion between Glucosylceramide and Ceramide by Scaffold Tailoring of Iminosugar Inhibitors

Molecules, 2019
A series of simple C-alkyl pyrrolidines already known as cytotoxic inhibitors of ceramide glucosylation in melanoma cells can be converted into their corresponding 6-membered analogues by means of a simple ring expansion.
Cécile Baudoin-Dehoux, Tessa Castellan, Frédéric Rodriguez, Arnaud Rives, Fabien Stauffert, Virginie Garcia, Thierry Levade, Philippe Compain, Yves Génisson   +8 more
doaj   +1 more source

Iminosugar‐Dihydroazulenes as Mutant L444P Glucocerebrosidase Enhancers [PDF]

Chemistry & Biodiversity
AbstractA remarkable enhancer of human glucocerebrosidase enzyme (GCase) was identified among a set of dihydroazulene‐tagged iminosugars. An unprecedented 3.9‐fold increase in GCase activity was detected on fibroblasts bearing the homozygous L444P mutation, which is frequently associated with neuronopathic Gaucher forms, and which commonly results ...
Maria Giulia Davighi, Francesca Clemente, Emilie Sperling Andreasen, Mogens Brøndsted Nielsen, Camilla Matassini, Andrea Goti, Amelia Morrone, Paolo Paoli, Francesca Cardona, Martina Cacciarini   +9 more
openaire   +4 more sources

An Australian standard of care for Niemann–Pick disease type C

Internal Medicine Journal, EarlyView.
Abstract Background Niemann–Pick disease type C (NP‐C) is the fifth most prevalent lysosomal disorder in Australia. Diagnostic delay is common, impacted by disease heterogeneity, limited awareness within clinical gateway services and exclusion from state‐based newborn screening programmes.
Michel Tchan, Nicholas Smith, Heidi Peters, Ellie Van Velsen, Catherine Marraffa, Carolyn Ellaway, Katrina Cruz, Shekeeb S. Mohammad, Maina Kava, Joy Yaplito‐Lee, Shanti Balasubramaniam, Yusof Rahman, Brendon Boot, Ashley Bush, Felicity Munro, Leniza Hamoy, Ya Hui Hung, Philippa Johnston, Deanna Carpino, Molly Williams, Sharmila Kiss, Rebecca Quin, Ingrid Sutherland, Mark Walterfang   +23 more
wiley   +1 more source

A new approach toward the total synthesis of (+)-batzellaside B

Beilstein Journal of Organic Chemistry, 2012
A new synthetic approach to (+)-batzellaside B from naturally abundant L-pyroglutamic acid is presented in this article. The key synthetic step involves Sharpless asymmetric dihydroxylation of an olefinic substrate functionalized with an acetoxy group to
Jolanta Wierzejska, Shin-ichi Motogoe, Yuto Makino, Tetsuya Sengoku, Masaki Takahashi, Hidemi Yoda   +5 more
doaj   +1 more source

Thiol-ene "Click" Synthesis and Pharmacological Evaluation of C-Glycoside sp²-Iminosugar Glycolipids

Molecules, 2019
The unique stereoelectronic properties of sp2-iminosugars enable their participation in glycosylation reactions, thereby behaving as true carbohydrate chemical mimics.
Elena M. Sánchez-Fernández, M. Isabel García-Moreno, Raquel García-Hernández, José M. Padrón, José M. García Fernández, Francisco Gamarro, Carmen Ortiz Mellet   +6 more
doaj   +1 more source

Natural iminosugar (+)-lentiginosine inhibits ATPase and chaperone activity of hsp90. [PDF]

PLoS ONE, 2012
Heat shock protein 90 (Hsp90) is a significant target in the development of rational cancer therapy due to its role at the crossroads of multiple signaling pathways associated with cell proliferation and cell viability.
Fabrizio Dal Piaz, Antonio Vassallo, Maria Giovanna Chini, Franca M Cordero, Francesca Cardona, Claudio Pisano, Giuseppe Bifulco, Nunziatina De Tommasi, Alberto Brandi   +8 more
doaj   +1 more source

The transformative power of structural predictions with AI in plant science

The Plant Journal, Volume 125, Issue 6, March 2026.
SUMMARY Since the introduction of various structural prediction programs, the emerging transformative power of these technologies in plant science is apparent. Not only programs like AlphaFold but also RoseTTAFold, Chai‐1 and Boltz suddenly enable plant scientists to predict structures with high confidence. This ability has facilitated the discovery of
Joy Chenqu Lyu, Renier A. L. Van der Hoorn   +1 more
wiley   +1 more source

Synthesis of Substituted Cyclic Amines From Protected Amino Acids Using Oxidative Decarboxylation and Alkylation

Asian Journal of Organic Chemistry, Volume 15, Issue 2, February 2026.
Simple access to alkylated 3D scaffold via oxidative radical decarboxylation, trapping of iminium, and successive reaction with organometallic reagent in the presence of BF3 . ABSTRACT Cyclic amines are vital scaffolds in bioactive molecules and drug discovery, often functionalized via electrochemical Shono‐type oxidation to access N‐acyliminium ...
Dario Corbisiero, Arthur F. Rossignol, Francesco Calogero, Andrea Gualandi, Emanuele Pinosa, Luca Sensoli, Paolo Ronchi, Pier Giorgio Cozzi   +7 more
wiley   +1 more source

A Novel Iminosugar UV-12 with Activity against the Diverse Viruses Influenza and Dengue (Novel Iminosugar Antiviral for Influenza and Dengue)

Viruses, 2015
Iminosugars are capable of targeting the life cycles of multiple viruses by blocking host endoplasmic reticulum α-glucosidase enzymes that are required for competent replication of a variety of enveloped, glycosylated viruses.
Kelly L. Warfield, Emily Plummer, Dominic S. Alonzi, Gary W. Wolfe, Aruna Sampath, Tam Nguyen, Terry D. Butters, Sven G. Enterlein, Eric J. Stavale, Sujan Shresta, Urban Ramstedt   +10 more
doaj   +1 more source

Development of Peptide Glucosyltransferase Inhibitors With Comprehensive Coverage Across Clostridioides difficile Toxin B Sub‐Types

Biotechnology and Bioengineering, Volume 123, Issue 2, Page 310-323, February 2026.
ABSTRACT Clostridioides difficile infection presents an escalating clinical challenge due to the proliferation of hypervirulent and antibiotic‐resistant strains. The primary symptoms of disease, namely colitis and diarrhea, are induced by the release of two toxins: TcdA and TcdB.
Carly M. Catella, Sudeep Sarma, Caroline M. Hinesley, Corey E. Febo, Keith A. Breau, Deniz Durmusoglu, Ethan Purnell, Scott T. Magness, Carol K. Hall, Stefano Menegatti, Nathan Crook   +10 more
wiley   +1 more source