Results 61 to 70 of about 2,892 (197)

Unusual architecture of the p7 channel from hepatitis C virus [PDF]

, 2014
The Hepatitis C virus (HCV) has developed a small membrane protein, p7, which remarkably can self-assemble into a large channel complex that selectively conducts cations1-4.
Berardi, Marcelo J., Chou, James J., Dev, Jyoti, OuYang, Bo, Sun, Bing, Xie, Shiqi, Yu, Wenjing, Zhao, Xinhao   +7 more
core   +1 more source

sp2-Iminosugars targeting human lysosomal β-hexosaminidase as pharmacological chaperone candidates for late-onset Tay-Sachs disease

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
The late-onset form of Tay-Sachs disease displays when the activity levels of human β-hexosaminidase A (HexA) fall below 10% of normal, due to mutations that destabilise the native folded form of the enzyme and impair its trafficking to the lysosome ...
Manuel González-Cuesta, Irene Herrera-González, M. Isabel García-Moreno, Roger A. Ashmus, David J. Vocadlo, José M. García Fernández, Eiji Nanba, Katsumi Higaki, Carmen Ortiz Mellet   +8 more
doaj   +1 more source

Evaluation of nonnatural L-iminosugar C,C-glycosides, a new class of C-branched iminosugars, as glycosidase inhibitors

Carbohydrate Research, 2023
Capitalizing on a previously developed Staudinger/azaWittig/Grignard (SAWG)-ring contraction sequence that furnished protected six-membered L-iminosugar C,C-glycosides bearing an allyl group and various substituents at the pseudoanomeric position, the synthesis and glycosidase inhibition of a small library of six- and seven-membered L-iminosugar C,C ...
Jérôme Désiré, Zakaria Debbah, David Gueyrard, Jérôme Marrot, Yves Blériot, Atsushi Kato   +5 more
openaire   +3 more sources

Therapeutic Effects of Nizubaglustat in a Mouse Model of GM2 Gangliosidosis

Journal of Inherited Metabolic Disease, Volume 49, Issue 1, January 2026.
ABSTRACT Nizubaglustat is a novel selective inhibitor of glucosylceramide synthase (GCS) and the non‐lysosomal glucocerebrosidase (NLGase, GbA2) with brain penetrant properties. It is currently in clinical development as an oral treatment for rare lysosomal storage diseases with neurological involvement. One such disease group called GM2 gangliosidosis,
Kyle Landskroner, Kshitiz Singh, Melissa Mitchell, Jagdeep S. Walia   +3 more
wiley   +1 more source

Synthesis and Biological Evaluation of New Dihydrofuro[3,2-b]piperidine Derivatives as Potent α-Glucosidase Inhibitors

Molecules
Inhibition of glycoside hydrolases has widespread application in the treatment of diabetes. Based on our previous findings, a series of dihydrofuro[3,2-b]piperidine derivatives was designed and synthesized from D- and L-arabinose.
Haibo Wang, Xiaojiang Huang, Yang Pan, Guoqing Zhang, Senling Tang, Huawu Shao, Wei Jiao   +6 more
doaj   +1 more source

Advances in the synthesis of Homochiral (-)-1-azafagomine and (+)-5-epi-1-azafagomine. 1-N-phenyl carboxamide derivatives of both enantiomers of 1-azafagomine: leads for the synthesis of active α-Glycosidase inhibitors [PDF]

, 2011
- A new expeditious preparation of homochiral (-)-1-azafagomine, and (+)-5-epi-1-azafagomine has been devised. Stoodley´s diastereoselective cycloaddition of dienes bearing a 2,3,4,6-tetraacetyl glucosyl chiral auxiliary to 4-phenyl-1,2,4-triazole-3,5 ...
Alves, M. José, Costa, Flora Teixeira e, Duarte, Vera C. M., Fortes, A. Gil, Martins, J. A. R., Micaelo, N. M.   +5 more
core   +1 more source

Synthesis of an N‐Galactosyl Norbornane Aziridine and its Potent Mixed Inhibition of Aspergillus oryzae β‐Galactosidase

ChemBioChem, Volume 26, Issue 23, November 27, 2025.
An N‐galactosyl aziridine is found to have μM range mixed inhibition constants (K i and K i’) for a fungal β‐galactosidase. Aziridine‐bearing cyclic polyols are established as irreversible covalent inhibitors of glycosyl hydrolases and have been employed as activity‐based probes.
Aaron McCormack, Ronan Gavin, Mikael Bols, Paul V. Murphy   +3 more
wiley   +1 more source

Dietary Consumption of Type 2 Resistant Starch and d‐Fagomine Delays Progression of Metabolic Disturbances in Male Rats on High‐Fat Diet

Molecular Nutrition &Food Research, Volume 69, Issue 22, November 2025.
This study compared the preventive effects of dietary resistant starch (RS2) from maize and d‐fagomine (FG) from buckwheat on cardiometabolic risk factors in high‐fat (HF) diet‐fed rats. Wistar‐Kyoto rats (n = 11–12/group) received STD, HF, HF + RS, or HF + FG diets for 10 weeks.
Bernat Miralles‐Pérez, Sara Ramos‐Romero, María José Charpentier, Vanessa Sánchez‐Martos, Àngels Fortuño‐Mar, Julia Ponomarenko, Susana Amézqueta, David Piñol‐Piñol, Xiang Zhang, Josep Lluís Torres, Marta Romeu   +10 more
wiley   +1 more source

Safety assessment of a standardized cucumber extract (Q-Actin™): Oral repeat-dose toxicity and mutagenicity studies

Toxicology Reports, 2018
Cucumus sativus (cucumber) is one of the most widely consumed fruit vegetables worldwide. Recent discovery of iminosugars in commonly consumed fruits and vegetables has promoted the interest in isolating these compounds and understanding the potential ...
S. Kothari, M. Saravana, S. Muthusamy, A. Mozingo, M. Soni   +4 more
doaj   +1 more source

The Sweet Aspects of Orthoflavivirus Treatment Design and Vaccine Development

Journal of Medical Virology, Volume 97, Issue 10, October 2025.
ABSTRACT Viruses in the genus Orthoflavivirus are among the most important human pathogens because of their significant public health impact. Many strategies have been proposed to develop specific or broad‐spectrum treatments and preventive measures for these viral infections in humans.
Ana C. Alcalá, Michelle Gutiérrez, Juan E. Ludert   +2 more
wiley   +1 more source