Results 71 to 80 of about 2,892 (197)

Synthesis of the first examples of iminosugar clusters based on cyclopeptoid cores

Beilstein Journal of Organic Chemistry, 2014
Cyclic N-propargyl α-peptoids of various sizes were prepared by way of macrocyclizations of linear N-substituted oligoglycines. These compounds were used as molecular platforms to synthesize a series of iminosugar clusters with different valency and ...
Mathieu L. Lepage, Alessandra Meli, Anne Bodlenner, Céline Tarnus, Francesco De Riccardis, Irene Izzo, Philippe Compain   +6 more
doaj   +1 more source

Skeletal improvement in patients with Gaucher disease type 1: a phase 2 trial of oral eliglustat [PDF]

, 2014
Objective: Eliglustat is an investigational oral substrate reduction therapy for Gaucher disease type 1 (GD1). Its skeletal effects were evaluated by prospective monitoring of bone mineral density (BMD), fractures, marrow infiltration by Gaucher cells ...
Aguzzi, Rasha, Arreguin, Elsa Avila, Dragosky, Marta, Kamath, Ravi S., Lukina, Elena, Norfleet, Andrea M., Pastores, Gregory M., Peterschmitt, M. Judith, Puga, Ana Cristina, Rosenbaum, Hanna, Rosenthal, Daniel I., Watman, Nora, Zimran, Ari   +12 more
core   +1 more source

A Fullerene‐Based Selenosugar Ball

European Journal of Organic Chemistry, Volume 28, Issue 36, September 29, 2025.
A fullerene hexakis‐adduct decorated with 12 peripheral seleno‐d‐talitol moieties is synthesized efficiently with a Th‐symmetry from a hexakis‐adduct of [60]fullerene prepared by a cycloaddition reaction and subsequent copper‐catalyzed azide‐alkyne cycloaddition click chemistry.
Reinier Lemos, Yoana Pérez‐Badell, Mauro De Nisco, Giovanna Cimmino, Claudia González, Andrea Carpentieri, Severina Pacifico, Margarita Suárez, Silvana Pedatella   +8 more
wiley   +1 more source

Synthesis and Glycosidase Inhibition Properties of Calix[8]arene-Based Iminosugar Click Clusters

Pharmaceuticals, 2020
A set of 6- to 24-valent clusters was constructed with terminal deoxynojirimycin (DNJ) inhibitory heads through C6 or C9 linkers by way of Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reactions between mono- or trivalent azido-armed iminosugars and
Jérémy P. Schneider, Stefano Tommasone, Paolo Della Sala, Carmine Gaeta, Carmen Talotta, Céline Tarnus, Placido Neri, Anne Bodlenner, Philippe Compain   +8 more
doaj   +1 more source

Inhibiting influenza virus replication using novel and established antiviral compounds

, 2011
Circulating influenza viruses have the potential to cause pandemics, as seen in 2009 with the emergence of a novel H1N1 virus that rapidly disseminated worldwide.
Brookes, Daniel William, Brookes, Daniel William   +1 more
core   +1 more source

Effectiveness of Cucumis sativus L. Supplementation on Mood, Anxiety, and Sleep Quality: A Randomized Double‐Blind Placebo‐Controlled Study

Health Science Reports, Volume 8, Issue 7, July 2025.
ABSTRACT Background and Aims Despite widespread use, more research is needed to assess the health effects of herbal plants. Preliminary research indicates that cucumber extract (Cucumis sativus L.) is safe and may exhibit analgesic properties for joint pain, but studies on its impact on other health‐related outcomes—including mood, sleep, and health ...
Heather A. Hausenblas, David Hooper, Stephanie Hooper   +2 more
wiley   +1 more source

Tuning the activity of iminosugars: novel N-alkylated deoxynojirimycin derivatives as strong BuChE inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
We have designed unprecedented cholinesterase inhibitors based on 1-deoxynojirimycin as potential anti-Alzheimer’s agents. Compounds are comprised of three key structural motifs: the iminosugar, for interaction with cholinesterase catalytic anionic site (
Ana I. Ahuja-Casarín, Penélope Merino-Montiel, José Luis Vega-Baez, Sara Montiel-Smith, Miguel X. Fernandes, Irene Lagunes, Inés Maya, José M. Padrón, Óscar López, José G. Fernández-Bolaños   +9 more
doaj   +1 more source

A Biocatalytic Cascade for the Valorization of Sugars

ChemCatChem, Volume 17, Issue 12, June 23, 2025.
We report a one‐pot, three‐step biocatalytic cascade to synthesize trihydroxy‐piperidine and ‐azepane iminosugars directly from monosaccharides, employing transaminase (ATA) and galactose oxidase (GOase) enzymes. Abstract Biocatalytic cascades offer products of multistep synthesis without the use of protecting groups or isolation of intermediates. This
Kathryn Yeow, Aoife Martin, Jimmy Muldoon, Marianne Bore Haarr, Elaine O'Reilly   +4 more
wiley   +1 more source

Design, synthesis and photochemical properties of the first examples of iminosugar clusters based on fluorescent cores

Beilstein Journal of Organic Chemistry, 2015
The synthesis and photophysical properties of the first examples of iminosugar clusters based on a BODIPY or a pyrene core are reported. The tri- and tetravalent systems designed as molecular probes and synthesized by way of Cu(I)-catalysed azide–alkyne ...
Mathieu L. Lepage, Antoine Mirloup, Manon Ripoll, Fabien Stauffert, Anne Bodlenner, Raymond Ziessel, Philippe Compain   +6 more
doaj   +1 more source

Structural dissection of a complex Bacteroides ovatus gene locus conferring xyloglucan metabolism in the human gut [PDF]

, 2016
The human gastrointestinal tract harbours myriad bacterial species, collectively termed the microbiota, that strongly influence human health. Symbiotic members of our microbiota play a pivotal role in the digestion of complex carbohydrates that are ...
Brumer, Harry, Coyle, Travis, Davies, Gideon J., Goddard-Borger, Ethan D., Hemsworth, Glyn R., Larsbrink, Johan, Sobala, Łukasz F., Spadiut, Oliver, Stepper, Judith, Stubbs, Keith A., Thompson, Andrew J.   +10 more
core   +3 more sources