Results 81 to 90 of about 2,892 (197)

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2021–2022

Mass Spectrometry Reviews, Volume 44, Issue 3, Page 213-453, May/June 2025.
Abstract The use of matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this review is the 12th update of the original article published in 1999 and brings coverage of the literature to the end of 2022.
David J. Harvey
wiley   +1 more source

Expansion of the diversity of dispersin scaffolds

Acta Crystallographica Section D, Volume 81, Issue 3, Page 130-146, March 2025.
Five GH20‐family dispersins were characterized for activity on aryl glycosides and poly‐β‐1,6‐linked N‐acetyl‐d‐glucosamine oligomers and three crystal structures were solved, including two complexes with bound inhibitors.Microorganisms are known to secrete copious amounts of extracellular polymeric substances (EPS) that form complex matrices around ...
Alexandra Males, Olga V. Moroz, Elena Blagova, Astrid Munch, Gustav H. Hansen, Annette H. Johansen, Lars H. Østergaard, Dorotea R. Segura, Alexander Eddenden, Anne V. Due, Martin Gudmand, Jesper Salomon, Sebastian R. Sørensen, João Paulo L. Franco Cairo, Mark Nitz, Roland A. Pache, Rebecca M. Vejborg, Sandeep Bhosale, David J. Vocadlo, Gideon J. Davies, Keith S. Wilson   +20 more
wiley   +1 more source

Iminoazúcares sp2 en inmunoterapias contra el cáncer [PDF]

, 2016
En la actualidad, los tratamientos más utilizados para combatir el cáncer se basan en el uso de quimioterapia, radioterapia y cirugía. El principal inconveniente que presentan estas terapias es la escasa selectividad que presentan, lo que implica que ...
Guillén Poza, Pablo Adrián
core  

Evaluation of the Landscape of Pharmacodynamic Biomarkers in GM1 and GM2 Gangliosidosis

Clinical and Translational Science, Volume 18, Issue 3, March 2025.
ABSTRACT GM1 and GM2 gangliosidosis are inherited, progressive, neurodegenerative lysosomal disorders of variable onset and disease progression. GM1 gangliosidosis is a result of biallelic pathogenic variants in the GLB1 gene, which confer absent or reduced β‐galactosidase enzyme activity and lead to the accumulation of glycoconjugates such as ...
Sydney Stern, Karryn Crisamore, Ruo‐Jing Li, Michael Pacanowski, Robert Schuck   +4 more
wiley   +1 more source

Diastereoselective Entry to Novel Aminoindolizidines with Fused Furan, Thiophene, and Pyrrole Ring Starting from L‐Glutamic Acid

European Journal of Organic Chemistry, Volume 28, Issue 6, February 10, 2025.
A series of novel aminoindolizidines fused to (tetrahydro)furan, thiophene or pyrrole nuclei were synthesized using a concise and diastereoselective approach from optically pure tricyclic heteroaryl‐indolizidinols as key substrates. The synthesis involved Jurjew‐type skeletal rearrangement, Staudinger reduction, Thompson azidation and Ra−Ni mediated ...
Paula Fraňová, Peter Šafář, Ján Moncoľ, Ivana Žídeková, Adam Daïch, Štefan Marchalín   +5 more
wiley   +1 more source

Synthesis and biological evaluation of nojirimycin- and pyrrolidine-based trehalase inhibitors

Beilstein Journal of Organic Chemistry, 2012
A small set of nojirimycin- and pyrrolidine-based iminosugar derivatives has been synthesized and evaluated as potential inhibitors of porcine and insect trehalases.
Davide Bini, Francesca Cardona, Matilde Forcella, Camilla Parmeggiani, Paolo Parenti, Francesco Nicotra, Laura Cipolla   +6 more
doaj   +1 more source

Glycoside Mimics from Glycosylamines: Recent Progress

Molecules, 2018
Glycosylamines are valuable sugar derivatives that have attracted much attention as synthetic intermediates en route to iminosugar-C-glycosyl compounds.
Cyril Nicolas, Olivier R. Martin
doaj   +1 more source

Intramolecular [3+2] cycloaddition of azido-unsaturated esters derived of monosaccharides [PDF]

, 2013
Iminosugars have been shown to be very potent inhibitors of glycosidases and glycolsyltransferases. Due to their ability to resemble the transition states of the sugars involved in these processes, a variety of m onocyclic and bicyclic iminosugars have
Calvo-Losada, Saturnino, Pino-Gonzalez, Maria Soledad, Quirante-Sanchez, Jose Joaquin, Romero-Carrasco, Antonio   +3 more
core  

Evaluation of miglustat as maintenance therapy after enzyme therapy in adults with stable type 1 Gaucher disease: a prospective, open-label non-inferiority study. [PDF]

, 2013
BACKGROUND: Previous studies have provided equivocal data on the use of miglustat as maintenance therapy in Gaucher disease type 1. We report findings from a clinical trial evaluating the effects of miglustat treatment in patients with stable type 1 ...
Amato, Dominick, Cox, Timothy M, Giorgino, Ruben, Hollak, Carla Em, Luzy, Cecile, Miglustat Maintenance Study Group, Silkey, Mariabeth, Steiner, Robert D   +7 more
core   +2 more sources

Correction of liver steatosis by a hydrophobic iminosugar modulating glycosphingolipids metabolism.

PLoS ONE, 2012
The iminosugar N-(5'-adamantane-1'-yl-methoxy)-pentyl-1-deoxynoijirimycin (AMP-DNM), an inhibitor of glycosphingolipid (GSL) biosynthesis is known to ameliorate diabetes, insulin sensitivity and to prevent liver steatosis in ob/ob mice.
Elisa Lombardo, Cindy P A A van Roomen, Gijs H van Puijvelde, Roelof Ottenhoff, Marco van Eijk, Jan Aten, Johan Kuiper, Herman S Overkleeft, Albert K Groen, Arthur J Verhoeven, Johannes M F G Aerts, Florence Bietrix   +11 more
doaj   +1 more source