Results 71 to 80 of about 114,851,153 (292)

Targeting the PHB2–ACSL3 Lipid‐Remodeling Axis Overcomes Cisplatin Resistance by Restoring Ferroptosis in Gastric Cancer

Advanced Science, EarlyView.
ABSTRACT Platinum‐based chemotherapy resistance remains a major obstacle in gastric cancer (GC) treatment. Through integrated transcriptomic profiling of cisplatin‐resistant xenografts and pharmacogenomic interrogation of the NCI‐60 dataset, we identified Prohibitin‐2 (PHB2) as a previously unrecognized determinant of chemoresistance.
Liang Xu, Wanying Xiang, Xinyue Wang, Yue Pan, Jing Gao, Jiezhen Yang, Yufei Wang, Zhipu Zhu, Man Tong, Lei Jin, Yan Ye   +10 more
wiley   +1 more source

A review of in-vitro digestibility models on diverse foods in various segments of human digestive tract

Discover Food
In order to simulate the process of food digestion in the gastrointestinal (GI) tract, various in-vitro digestion models have been developed. These models vary from simple, single-compartment systems to more complex setups with multiple compartments and ...
B. Shiva Kiran, Omar Bashir, Prashant Anil Pawase, Kshirod Kumar Dash, Tawheed Amin, Rafeeya Shams, Ayaz Mukarram Shaikh, Kovács Béla   +7 more
doaj   +1 more source

Purification and Characterization of Buckwheat Bee Pollen Polysaccharide and Changes of Its Antioxidant Activity during in Vitro Digestion

Shipin gongye ke-ji
This paper aimed to investigate the antioxidant activity of buckwheat bee pollen polysaccharides (BWPP) during the in vitro gastrointestinal digestion. The crude polysaccharides were purified using DEAE-52 cellulose column and their antioxidant activity ...
Hua WANG, Jingjing MENG, Yunxiao MA, Zhiwei ZHANG, Lili YU, Jixing ZHANG, Wenxi ZHOU   +6 more
doaj   +1 more source

Comparison on Protein Bioaccessibility of Soymilk Gels Induced by Glucono-δ-Lactone and Lactic Acid Bacteria

Molecules, 2022
In this study, the protein bioaccessibility of soymilk gels produced by the addition of glu-cono-δ-lactone (GDL) and fermentation with lactic acid bacteria (LAB) was examined using an in vitro gastrointestinal simulated digestion model.
Tianran Hui, Ting Tang, Xuan Gu, Zhen Yuan, Guangliang Xing   +4 more
doaj   +1 more source

Oral Nanomicelle‐Mediated Sequential Butyrate Production in the Intestine for Ulcerative Colitis and Immunosuppression Treatment

Advanced Science, EarlyView.
After oral administration, inodorous GLU‐BA self‐assembles into nanomicelles in aqueous environments to resist premature gastric adsorption. Upon reaching the intestine, endogenous esterases rapidly cleave the built‐in ester bonds in these nanomicelles to release BA and GLU, with GLU further metabolized by gut microbiota to gradually generate BA ...
Feifei Xin, Zhike Xie, Danyue Zhao, Lin Yang, Yiqun Wan, Zuwei Liu, Situ Xiong, Ying Zhang, Lei Feng, Hao Wan   +9 more
wiley   +1 more source

Exploring the Antioxidant Activity and Impact on Gut Microbiota of Brassica rapa L. Polysaccharides Based on an in Vitro Digestion and Fermentation Model

Shipin gongye ke-ji
Objective: This study aimed to investigate the changes in antioxidant activity of turnip polysaccharides during in vitro simulated gastrointestinal digestion and to analyze their effects on gut microbiota diversity using an in vitro fecal anaerobic ...
Mengying ZHANG, Kaiyue BI, Yuhan WU, Wei LI, Wei LI, Yanbo LI, Yu ZHAO, Wei WANG   +7 more
doaj   +1 more source

Maillard-Type Protein–Polysaccharide Conjugates and Electrostatic Protein–Polysaccharide Complexes as Delivery Vehicles for Food Bioactive Ingredients: Formation, Types, and Applications

Gels, 2022
Due to their combination of featured properties, protein and polysaccharide-based carriers show promising potential in food bioactive ingredient encapsulation, protection, and delivery.
Xiaohong Sun, Hao Wang, Shengnan Li, Chunli Song, Songyuan Zhang, Jian Ren, Chibuike C. Udenigwe   +6 more
doaj   +1 more source

Comparison of antioxidant activities of bovine whey proteins before and after simulated gastrointestinal digestion [PDF]

, 2018
peer-reviewedOxidative stress caused by free radicals has been implicated in several human disorders. Dietary antioxidants can help the body to counteract those reactive species and reduce oxidative stress.
Sariçay, Yunus, Arranz Gutiérrez, Elena María, Giblin, Linda, Kelly, Philip, Kelly, Phil M., Kelly, Phil M, Corrochano, Alberto R., Buckin, Vitaly, Corrochano, Alberto R, Arranz, Elena   +9 more
core   +1 more source

TH/TRs–COL11A2 Axis Mediates Loss of a Differentiated Astrocyte State in Hypogyrified Brains

Advanced Science, EarlyView.
Using a gyrencephalic congenital hypothyroidism pig model, this study reveals cerebral atrophy and cortical hypogyrification. Single‐cell sequencing identifies astrocytes as major TH‐responsive cells, with the COL11A2‐enriched Astro‐2 state nearly absent.
Ying Zhang, Xiao Wang, Hongyan Ma, Pengcheng Lyu, Shuangjie Tian, Ruojun Zong, Jiani Chen, Gang Ren, Yongjiang Yang, Zichen Yang, Guosong Qin, Naishi Li, Yanfang Wang, Jianwei Jiao, Jianguo Zhao   +14 more
wiley   +1 more source

Multifunctional Zinc Glycyrrhizinate‐Integrated Gel for Enhanced Probiotic Delivery and Alleviation of Acute and Spontaneous Colitis

Advanced Science, EarlyView.
Multifunctional oral delivery system—L. reuteri@ZGM—act as both a carrier and therapeutic adjuvant, providing ROS scavenging, and mucin‐interactive properties tailored to the IBD microenvironment. This bioactive gel safeguards L. reuteri from gastric degradation, enhances mucosal adhesion, and promotes long‐term retention at inflamed sites, thereby ...
Mengyun Peng, Xiaochun Chen, Wei Li, Shu Tang, Jun Zhou, Xia Wu, Dan Yuan, Zhongyan Shan, Junfeng Shi   +8 more
wiley   +1 more source