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Journal of Immunology Research, 2015 Tuberculosis (TB) remains a serious global public health problem that results in up to 2 million deaths each year. TB is caused by the human pathogen, Mycobacterium tuberculosis (Mtb), which infects primarily innate immune cells patrolling the lung ...
Jonathan Kevin Sia +2 more
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Innate Lymphoid Cells in Mucosal Immunity [PDF]
Frontiers in Immunology, 2019 Innate lymphoid cells (ILCs) are innate counterparts of T cells that contribute to immune responses by secreting effector cytokines and regulating the functions of other innate and adaptive immune cells. ILCs carry out some unique functions but share some tasks with T cells.
Panda, Santosh K, Colonna, Marco
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Helminth Infections: Recognition and Modulation of the Immune Response by Innate Immune Cells [PDF]
, 2018 The survival of helminths in the host over long periods of time is the result of a process of adaptation or dynamic co-evolution between the host and the parasite. However, infection with helminth parasites causes damage to the host tissues producing the
Ambrosio, Laura Fernanda +7 more
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Metabolism of Innate Immune Cells in Cancer [PDF]
Cancers, 2021 Cancer cells possess specific metabolic requirements for their survival, proliferation, and progression. Within a shared microenvironment, immune cells depend on competing metabolic pathways for their development and effector function. As a result, local acidification, hypoxia, and nutrient depletion in the tumor microenvironment can alter the ...
Talty, Ronan, Olino, Kelly
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Targeting Innate Immunity to Enhance the Efficacy of Radiation Therapy
Frontiers in Immunology, 2019 Radiation continues to play a major role in the treatment of almost every cancer type. Traditional radiation studies focused on its ability to damage DNA, but recent evidence has demonstrated that a key mechanism driving the efficacy of radiation in vivo
Tahir B. Dar +3 more
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Innate Immune Cells to the Help [PDF]
Immunity, 2014 A study by Halim and Steer (2014) in this issue of Immunity shows that innate lymphoid cells type 2 (ILC2s) are crucial for inducing adaptive T helper 2 immunity by providing interleukin-13. Another study by van Dyken et al. (2014) shows that ILC2s control eosinophilia and alternative activation of macrophages.
Bart N. Lambrecht, Hamida Hammad
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Regulatory immune cells in transplantation [PDF]
, 2012 Immune regulation is fundamental to any immune response to ensure that it is appropriate for the perceived threat to the host. Following cell and organ transplantation, it is essential to control the innate immune response triggered by the injured ...
Bushell, Andrew +2 more
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CD14+ CD15- HLA-DR- myeloid-derived suppressor cells impair antimicrobial responses in patients with acute-on-chronic liver failure. [PDF]
, 2017 OBJECTIVE: Immune paresis in patients with acute-on-chronic liver failure (ACLF) accounts for infection susceptibility and increased mortality. Immunosuppressive mononuclear CD14+HLA-DR- myeloid-derived suppressor cells (M-MDSCs) have recently been ...
Adams, DH +14 more
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Platelet Interaction with Innate Immune Cells [PDF]
Transfusion Medicine and Hemotherapy, 2016 Beyond their traditional role in haemostasis and thrombosis, platelets are increasingly recognised as immune modulatory cells. Activated platelets and platelet-derived microparticles can bind to leukocytes, which stimulates mutual activation and results in rapid, local release of platelet-derived cytokines. Thereby platelets modulate leukocyte effector
Julia Barbara Kral +3 more
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Role of Innate lymphocytes in infection and inflammation
Frontiers in Immunology, 2012 Cooperation of innate and adaptive immune responses is critical for the protective immunity against various invading microbes. Distinct types of effector T cells play different roles in adaptive immune responses.
Shigeo eKoyasu, Kazuyo eMoro
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