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The critical role of iron homeostasis in neurodegenerative diseases [PDF]
Neural Regeneration ResearchNeurodegenerative diseases are prevalent conditions that greatly impact human health. These diseases are primarily characterized by the progressive loss and eventual death of neuronal function, although the precise mechanisms underlying these processes ...
Tiantian Liang +8 more
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Abnormal Iron Homeostasis and Neurodegeneration [PDF]
Frontiers in Aging Neuroscience, 2013 Abnormal iron metabolism is observed in many neurodegenerative diseases, however only two have shown dysregulation of brain iron homeostasis as the primary cause of neurodegeneration.
Barry B Muhoberac, Ruben eVidal
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Iron Homeostasis in Azotobacter vinelandii
Biology, 2023 Iron is an essential nutrient for all life forms. Specialized mechanisms exist in bacteria to ensure iron uptake and its delivery to key enzymes within the cell, while preventing toxicity.
Elena Rosa-Núñez +6 more
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Iron homeostasis in the lung [PDF]
Biological Research, 2006 Iron is essential for many aspects of cellular function. However, it also can generate oxygen-based free radicals that result in injury to biological molecules. For this reason, iron acquisition and distribution are tightly regulated.
ANDREW J GHIO +4 more
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Bacterial iron homeostasis [PDF]
FEMS Microbiology Reviews, 2003 Iron is essential to virtually all organisms, but poses problems of toxicity and poor solubility. Bacteria have evolved various mechanisms to counter the problems imposed by their iron dependence, allowing them to achieve effective iron homeostasis under a range of iron regimes.
Simon C, Andrews +2 more
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Iron homeostasis during pregnancy [PDF]
The American Journal of Clinical Nutrition, 2017 During pregnancy, iron needs to increase substantially to support fetoplacental development and maternal adaptation to pregnancy. To meet these iron requirements, both dietary iron absorption and the mobilization of iron from stores increase, a mechanism that is in large part dependent on the iron-regulatory hormone hepcidin.
Fisher, Allison L, Nemeth, Elizabeta
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G3: Genes, Genomes, Genetics, 2021 Monothiol glutaredoxins are important regulators of iron homeostasis that play conserved roles in the sensing and trafficking of iron-sulfur clusters.
Guanggan Hu +5 more
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Down the Iron Path: Mitochondrial Iron Homeostasis and Beyond
Cells, 2021 Cellular iron homeostasis and mitochondrial iron homeostasis are interdependent. Mitochondria must import iron to form iron–sulfur clusters and heme, and to incorporate these cofactors along with iron ions into mitochondrial proteins that support ...
Jonathan V. Dietz +2 more
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Annual Review of Entomology, 2023 Iron is an essential micronutrient for all types of organisms; however, iron has chemical properties that can be harmful to cells. Because iron is both necessary and potentially damaging, insects have homeostatic processes that control the redox state, quantity, and location of iron in the body.
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Metalloreductase Steap3 coordinates the regulation of iron homeostasis and inflammatory responses
Haematologica, 2012 Background Iron and its homeostasis are intimately related to inflammatory responses, but the underlying molecular mechanisms are poorly understood. We investigated the role of Steap3 in regulating iron homeostasis in macrophages, and the effects of ...
Fan Zhang +8 more
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