Results 21 to 30 of about 203,114 (264)
Mitoferrin, Cellular and Mitochondrial Iron Homeostasis
Cells, 2022 Iron is essential for many cellular processes, but cellular iron homeostasis must be maintained to ensure the balance of cellular signaling processes and prevent disease.
Md Yousuf Ali +3 more
doaj +1 more source
Liver iron sensing and body iron homeostasis [PDF]
Blood, 2019 Abstract The liver orchestrates systemic iron balance by producing and secreting hepcidin. Known as the iron hormone, hepcidin induces degradation of the iron exporter ferroportin to control iron entry into the bloodstream from dietary sources, iron recycling macrophages, and body stores. Under physiologic conditions, hepcidin production
Chia-Yu Wang, Jodie L. Babitt
openaire +2 more sources
Mitochondrial Iron Metabolism: The Crucial Actors in Diseases
Molecules, 2022 Iron is a trace element necessary for cell growth, development, and cellular homeostasis, but insufficient or excessive level of iron is toxic. Intracellularly, sufficient amounts of iron are required for mitochondria (the center of iron utilization) to ...
Geyan Duan +10 more
doaj +1 more source
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2012 Despite fluctuations in dietary iron intake and intermittent losses through bleeding, the plasma iron concentrations in humans remain stable at 10-30 μM. While most of the iron entering blood plasma comes from recycling, appropriate amount of iron is absorbed from the diet to compensate for losses and maintain nontoxic amounts in stores.
Ganz, Tomas, Nemeth, Elizabeta
openaire +2 more sources
The Role of the Liver in Iron Homeostasis and What Goes Wrong?
Journal of Renal and Hepatic Disorders, 2021 Iron is an essential mineral that is vital for growth development, normal cellular function, synthesis of hormones and connective tissue, and most importantly, serves as a component of hemoglobin to carry oxygen to body tissues. The body finely regulates
Ernesto Robalino Gonzaga +4 more
doaj +1 more source
NCOA4 maintains murine erythropoiesis via cell autonomous and non-autonomous mechanisms
Haematologica, 2019 Ncoa4 mediates autophagic degradation of ferritin, the cytosolic iron storage complex, to maintain intracellular iron homeostasis. Recent evidence also supports a role for Ncoa4 in systemic iron homeostasis and erythropoiesis.
Naiara Santana-Codina +11 more
doaj +1 more source
Current understanding of iron homeostasis [PDF]
The American Journal of Clinical Nutrition, 2017 Iron is an essential trace element, but it is also toxic in excess, and thus mammals have developed elegant mechanisms for keeping both cellular and whole-body iron concentrations within the optimal physiologic range. In the diet, iron is either sequestered within heme or in various nonheme forms.
Gregory J, Anderson, David M, Frazer
openaire +2 more sources
PLoS Pathogens, 2019 Iron homeostasis is important for growth, reproduction and other metabolic processes in all eukaryotes. However, the functions of ATP-binding cassette (ABC) transporters in iron homeostasis are largely unknown.
Zhihui Wang +7 more
doaj +1 more source
Antioxidants, 2023 Iron is essential for life. Many enzymes require iron for appropriate function. However, dysregulation of intracellular iron homeostasis produces excessive reactive oxygen species (ROS) via the Fenton reaction and causes devastating effects on cells ...
Jaewang Lee, Dong-Hoon Hyun
doaj +1 more source
Mechanisms of Mammalian Iron Homeostasis [PDF]
Biochemistry, 2012 Iron is vital for almost all organisms because of its ability to donate and accept electrons with relative ease. It serves as a cofactor for many proteins and enzymes necessary for oxygen and energy metabolism, as well as for several other essential processes. Mammalian cells utilize multiple mechanisms to acquire iron.
Kostas, Pantopoulos +3 more
openaire +2 more sources