Results 31 to 40 of about 203,114 (264)

Schizosaccharomyces pombe Grx4, Fep1, and Php4: In silico analysis and expression response to different iron concentrations

Frontiers in Genetics, 2022
Due to iron’s essential role in cellular metabolism, most organisms must maintain their homeostasis. In this regard, the fission yeast Schizosaccharomyces pombe (sp) uses two transcription factors to regulate intracellular iron levels: spFep1 under iron ...
Alia Ebrahim, Manal A. Alfwuaires, Mohammad H. Abukhalil, Mohammad H. Abukhalil, Fawaz Alasmari, Fawad Ahmad, Rui Yao, Ying Luo, Ying Huang   +8 more
doaj   +1 more source

Haptoglobin Polymorphism and Iron Homeostasis [PDF]

Clinical Chemistry, 2002
Abstract Background: There is a marked difference in the degree of expression of the homozygous C282Y HFE genotype that is associated with hereditary hemochromatosis. It has been reported that individuals with the haptoglobin 2-2 type manifest increased iron concentrations, including serum iron, transferrin saturation, and ferritin.
Ernest, Beutler, Terri, Gelbart, Pauline, Lee   +2 more
openaire   +2 more sources

Iron Homeostasis in the Lungs—A Balance between Health and Disease

Pharmaceuticals, 2019
A strong mechanistic link between the regulation of iron homeostasis and oxygen sensing is evident in the lung, where both systems must be properly controlled to maintain lung function.
Joana Neves, Thomas Haider, Max Gassmann, Martina U. Muckenthaler   +3 more
doaj   +1 more source

Duodenal Lamina Propria Transferrin—A New Player in the Mucosal Block of Dietary Iron Absorption? [PDF]

Indian Journal of Medical Biochemistry
Iron is an essential trace element, and its homeostasis is subjected to strict regulatory mechanisms. Hepcidin, a liver synthesized antimicrobial peptide, is the master regulator of systemic iron homeostasis.
Jagadish Ramasamy
doaj   +1 more source

Systemic iron homeostasis and erythropoiesis [PDF]

IUBMB Life, 2017
AbstractIron is an essential nutrient that is potentially toxic due to its redox reactivity. Insufficient iron supply to erythroid cells, the major iron consumers in the body, leads to various forms of anemia. On the other hand, iron overload (hemochromatosis) is associated with tissue damage and diseases of liver, pancreas, and heart.
George, Papanikolaou, Kostas, Pantopoulos   +1 more
openaire   +2 more sources

Iron homeostasis and eye disease [PDF]

Biochimica et Biophysica Acta (BBA) - General Subjects, 2009
Iron is necessary for life, but excess iron can be toxic to tissues. Iron is thought to damage tissues primarily by generating oxygen free radicals through the Fenton reaction.We present an overview of the evidence supporting iron's potential contribution to a broad range of eye disease using an anatomical approach.Iron can be visualized in the cornea ...
Allison, Loh, Majda, Hadziahmetovic, Joshua L, Dunaief   +2 more
openaire   +2 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Iron homeostasis: An anthropocentric perspective [PDF]

Journal of Biological Chemistry, 2017
The regulation of iron metabolism in biological systems centers on providing adequate iron for cellular function while limiting iron toxicity. Because mammals cannot excrete iron, mechanisms have evolved to control iron acquisition, storage, and distribution at both systemic and cellular levels.
Coffey, Richard, Ganz, Tomas
openaire   +4 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Research progress of the role of iron homeostasis in ferroptosis in Alzheimer’s disease

Guoji laonian yixue zazhi
Ferroptosis is a distinct type of cellular demise frequently identified in the cerebral tissues of individuals afflicted with Alzheimer’s disease (AD).
Luo Chenliang, Wu Guiyou, Li Zhenzhong, Huang Zhongshi   +3 more
doaj   +1 more source