Results 31 to 40 of about 6,762 (168)

5-Methylcytosine (m5C) modification in peripheral blood immune cells is a novel non-invasive biomarker for colorectal cancer diagnosis

Frontiers in Immunology, 2022
Current non-invasive tumor biomarkers failed to accurately identify patients with colorectal cancer (CRC), delaying CRC diagnosis and thus leading to poor prognosis.
Haofan Yin, Haofan Yin, Zhijian Huang, Zhijian Huang, Shiqiong Niu, Liang Ming, Hongbo Jiang, Liang Gu, Liang Gu, Weibin Huang, Weibin Huang, Jinye Xie, Yulong He, Yulong He, Changhua Zhang, Changhua Zhang   +15 more
doaj   +1 more source

The m6A/m1A/m5C-Related Methylation Modification Patterns and Immune Landscapes in Rheumatoid Arthritis and Osteoarthritis Revealed by Microarray and Single-Cell Transcriptome

Journal of Inflammation Research, 2023
Haishi Zheng,1,2 Yirixiati Aihaiti,2 Yongsong Cai,2 Qiling Yuan,2 Mingyi Yang,2 Zheng Li,2 Ke Xu,2 Peng Xu1,2 1Department of Orthopedics, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China; 2Department of Joint ...
Zheng H, Aihaiti Y, Cai Y, Yuan Q, Yang M, Li Z, Xu K, Xu P   +7 more
doaj  

Diagnostic and prognostic value of m5C regulatory genes in hepatocellular carcinoma

Frontiers in Genetics, 2022
Background: A high mortality rate makes hepatocellular carcinoma (HCC) one of the most common types of cancer globally. 5-methylcytosine (m5C) is an epigenetic modification that contributes to the prognosis of several cancers, but its relevance to HCC remains unknown. We sought to determine if the m5C-related regulators had any diagnostic or prognostic
Xiawei Yang, Feng Yang, Liugen Lan, Liugen Lan, Liugen Lan, Liugen Lan, Ning Wen, Ning Wen, Ning Wen, Ning Wen, Haibin Li, Haibin Li, Haibin Li, Haibin Li, Xuyong Sun, Xuyong Sun, Xuyong Sun, Xuyong Sun, Xuyong Sun   +18 more
openaire   +3 more sources

Small‐Molecule Activation of mRNA Translation by Click‐to‐Release Reaction in Cells

Angewandte Chemie, EarlyView.
A new method to control mRNA activity using bioorthogonal click‐to‐release reactions is presented. The 5′ cap is modified with a trans‐cyclooctene (TCO) that quickly reacts with hydroxyaryl‐tetrazines and efficiently releases the native cap 0. TCO‐capped mRNAs are initially translationally inactive but can be activated with non‐toxic, cell‐permeable ...
Tess Vosman, Friedrich Burba, Martin Sumser, Milan Vrabel, Hannes Mikula, Andrea Rentmeister   +5 more
wiley   +2 more sources

5-Methylcytosine (m5C) Modification Patterns and Tumor Immune Infiltration Characteristics in Clear Cell Renal Cell Carcinoma

Current Oncology, 2022
Recently, studies have revealed the prognostic value of 5-methylcytosine (m5C) in clear cell renal cell carcinoma (ccRCC). However, the role of m5C methylation in ccRCC immune infiltration and the immunotherapeutic response remains unknown.
Can Chen, Lin-Yuan Chen, Jie-Xin Zhang, Hua-Guo Xu   +3 more
doaj   +1 more source

Research advances of mRNA methylation in kidney diseases

Linchuang shenzangbing zazhi
Recently mRNA methylation modification has been extensively examined, including N6-methyladenosine (m6A), N5-methylcytidine (m5C) and N1-methyladenosine (m1A).
Shi-wen Zhang, Jun-jun Luan, Hua Zhou
doaj   +1 more source

Comprehensive Analysis of m5C Methylation Regulatory Genes and Tumor Microenvironment in Prostate Cancer

Frontiers in Immunology, 2022
Background5-Methylcytidine (m5C) methylation is an emerging epigenetic modification in recent years, which is associated with the development and progression of various cancers.
Guopeng Yu, Jiahao Bao, Ming Zhan, Jiangyi Wang, Xinjuan Li, Xin Gu, Shangqing Song, Qing Yang, Yushan Liu, Zhong Wang, Bin Xu   +10 more
doaj   +1 more source

RNA m5C methylation in cancer: mechanisms and biological impact. [PDF]

Oncogenesis
Guan Z, Li W, He Y, Guo W.
europepmc   +2 more sources

Machine-Learning-Based m5C Score for the Prognosis Diagnosis of Osteosarcoma

Journal of Oncology, 2021
Background. Osteosarcoma is a common and highly metastatic malignant tumor, and m5C RNA methylation regulates various biological processes. The purpose of this study was to explore the prognostic role of m5C in osteosarcoma using machine learning. Methods.
Haijie Zhang, Peipei Xu, Yichang Song
openaire   +2 more sources

m5C RNA Methylation Primarily Affects the ErbB and PI3K–Akt Signaling Pathways in Gastrointestinal Cancer

Frontiers in Molecular Biosciences, 2020
5-Methylcytosine (m5C) is a kind of methylation modification that occurs in both DNA and RNA and is present in the highly abundant tRNA and rRNA. It has an important impact on various human diseases including cancer.
Shixin Xiang, Shixin Xiang, Yongshun Ma, Yongshun Ma, Jing Shen, Jing Shen, Yueshui Zhao, Yueshui Zhao, Xu Wu, Xu Wu, Mingxing Li, Mingxing Li, Xiao Yang, Parham Jabbarzadeh Kaboli, Parham Jabbarzadeh Kaboli, Fukuan Du, Fukuan Du, Huijiao Ji, Huijiao Ji, Yuan Zheng, Xiang Li, Jing Li, Qinglian Wen, Zhangang Xiao, Zhangang Xiao   +24 more
doaj   +1 more source