Results 1 to 10 of about 5,548 (154)

NSUN2-mediated m5C modification of HBV RNA positively regulates HBV replication. [PDF]

PLoS Pathogens, 2023
Chronic hepatitis B virus (HBV) infection is a major cause of liver cirrhosis and liver cancer, despite strong prevention and treatment efforts.
Jiangpeng Feng, Tianmo Xu, Miao He, Jiali Li, Peipei Yao, Chengbao Ma, Shimin Yang, Zaichao Xu, Kun Yan, Xianying Chen, Hongyun Wang, Jiejie Liu, Cong Zeng, Yuchen Xia, Huan Yan, Li Zhou, Yu Chen   +16 more
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RNA m5C modification: from physiology to pathology and its biological significance [PDF]

Frontiers in Immunology
RNA 5-methylcytosine (m5C) modification is a crucial epitranscriptomic mark that regulates RNA stability, processing, and translation. Emerging evidence highlights its essential role in various physiological processes, including cellular differentiation,
Xi Chen, Xi Chen, Yixiao Yuan, Fan Zhou, Xiaobing Huang, Xiaobing Huang, Lihua Li, Jun Pu, Jun Pu, Yong Zeng, Xiulin Jiang   +10 more
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5-Methylcytosine (m5C) Modification Patterns and Tumor Immune Infiltration Characteristics in Clear Cell Renal Cell Carcinoma [PDF]

Current Oncology, 2022
Recently, studies have revealed the prognostic value of 5-methylcytosine (m5C) in clear cell renal cell carcinoma (ccRCC). However, the role of m5C methylation in ccRCC immune infiltration and the immunotherapeutic response remains unknown.
Can Chen, Lin-Yuan Chen, Jie-Xin Zhang, Hua-Guo Xu   +3 more
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NSUN2-mediated RNA m5C modification drives multiple myeloma progression by enhancing the stability of HIP1 mRNA [PDF]

Scientific Reports
RNA 5-methylcytosine (m5C) modification is a crucial epigenetic regulation, and aberrant m5C methylation is associated with the pathogenesis of certain cancers.
Yang Jiang, Jing Sun, Yuyan Chen, Lin Cheng, Saran Feng, Yan Wang, Congcong Sun   +6 more
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RNA m5C modification upregulates E2F1 expression in a manner dependent on YBX1 phase separation and promotes tumor progression in ovarian cancer [PDF]

Experimental and Molecular Medicine
5-Methylcytosine (m5C) is a common RNA modification that modulates gene expression at the posttranscriptional level, but the crosstalk between m5C RNA modification and biomolecule condensation, as well as transcription factor-mediated transcriptional ...
Xiaoyi Liu, Qinglv Wei, Chenyue Yang, Hongyan Zhao, Jie Xu, Youchaou Mobet, Qingya Luo, Dan Yang, Xinzhao Zuo, Ningxuan Chen, Yu Yang, Li Li, Wei Wang, Jianhua Yu, Jing Xu, Tao Liu, Ping Yi   +16 more
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Epigenetically upregulated NSUN2 confers ferroptosis resistance in endometrial cancer via m5C modification of SLC7A11 mRNA [PDF]

Redox Biology
Endometrial cancer (EC) is a prevalent gynecological malignancy worldwide, and 5-methylcytosine (m5C) modification of mRNA is a crucial epigenetic modification associated with the development and occurrence of several cancers.
Shuai-Jun Chen, Jun Zhang, Ting Zhou, Shan-Shan Rao, Qian Li, Ling-Yan Xiao, Si-Tian Wei, Hong-Feng Zhang   +7 more
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Integrative 5-Methylcytosine Modification Immunologically Reprograms Tumor Microenvironment Characterizations and Phenotypes of Clear Cell Renal Cell Carcinoma

Frontiers in Cell and Developmental Biology, 2021
The tumor microenvironment (TME) affects the biologic malignancy of clear cell renal cell carcinoma (ccRCC). The influence of the 5-methylcytosine (m5C) epigenetic modification on the TME is unknown.
Wenhao Xu, Wenhao Xu, Wenkai Zhu, Wenkai Zhu, Xi Tian, Xi Tian, Wangrui Liu, Yuanyuan Wu, Aihetaimujiang Anwaier, Aihetaimujiang Anwaier, Jiaqi Su, Jiaqi Su, Shiyin Wei, Yuanyuan Qu, Yuanyuan Qu, Hailiang Zhang, Hailiang Zhang, Dingwei Ye, Dingwei Ye   +18 more
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Modification of m5C regulators in sarcoma can guide different immune infiltrations as well as immunotherapy

Frontiers in Surgery, 2023
BackgroundRecent studies have found that 5-methylcytosine (m5C) modulators are associated with the prognosis and treatment of cancer. However, the relevance of m5C modulators in sarcoma prognosis and the tumour microenvironment is unclear.MethodsWe ...
Shusheng Wu, Mengge Li, Rixin Su, Hao Shen, Yifu He, Yangfan Zhou   +5 more
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m5C Regulator-mediated methylation modification clusters contribute to the immune microenvironment regulation of multiple myeloma

Frontiers in Genetics, 2022
Background: Multiple myeloma (MM) is a hematological malignancy in which plasma cells proliferate abnormally. 5-methylcytosine (m5C) methylation modification is the primary epigenetic modification and is involved in regulating the occurrence, development,
Hefei Ren, Chang Liu, Hongkun Wu, Zhenhua Wang, Sai Chen, Xiaomin Zhang, Jigang Ren, Huiying Qiu, Lin Zhou   +8 more
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Advances in RNA cytosine-5 methylation: detection, regulatory mechanisms, biological functions and links to cancer

Biomarker Research, 2020
As an important posttranscriptional modification of RNA, 5-methylcytosine (m5C) has attracted increasing interest recently, with accumulating evidence suggesting the involvement of RNA m5C modification in multiple cellular processes as well as ...
Chen Xue, Yalei Zhao, Lanjuan Li
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