m5C RNA modification in colorectal cancer: mechanisms and therapeutic targets
Journal of Translational Medicine5-Methylcytosine (m5C), an important RNA modification, has been extensively studied in colorectal cancer (CRC). In recent years, with advances in high-throughput sequencing technology and RNA modification detection tools, the role of m5C modification in ...
Jiawei Wang +5 more
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Frontiers in ImmunologyThe Corona Virus Disease (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), has quickly spread worldwide and resulted in significant morbidity and mortality.
Yan Xiong +5 more
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m6A and m5C modification of GPX4 facilitates anticancer immunity via STING activation. [PDF]
Cell Death Dis, 2023 AbstractCancer immunotherapy is arguably the most rapidly advancing realm of cancer treatment. Glutathione peroxidase 4 (GPX4) has emerged as the vital enzyme to prevent lipid peroxidation and maintain cellular redox homeostasis. However, the mechanism of GPX4 in the regulation of cancer immunotherapy of colon adenocarcinoma (COAD) are incompletely ...
Chen B +9 more
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Comprehensive analysis of key m5C modification-related genes in type 2 diabetes. [PDF]
Front Genet, 2022 Background: 5-methylcytosine (m5C) RNA methylation plays a significant role in several human diseases. However, the functional role of m5C in type 2 diabetes (T2D) remains unclear.Methods: The merged gene expression profiles from two Gene Expression Omnibus (GEO) datasets were used to identify m5C-related genes and T2D-related differentially expressed ...
Song Y +7 more
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The RNA m5C modification in R-loops as an off switch of Alt-NHEJ. [PDF]
Nat Commun, 2023 AbstractThe roles of R-loops and RNA modifications in homologous recombination (HR) and other DNA double-stranded break (DSB) repair pathways remain poorly understood. Here, we find that DNA damage-induced RNA methyl-5-cytosine (m5C) modification in R-loops plays a crucial role to regulate PARP1-mediated poly ADP-ribosylation (PARylation) and the ...
Yang H +11 more
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RNF115 upregulation by YBX1-dependent m5C modification promotes hepatocellular carcinoma progression. [PDF]
NPJ Precis OncolLi J, Chen H, Bai L, Tang H.
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Isoimperatorin improves osteoporosis by increasing YBX1 expression to promote BGLAP m5C modification. [PDF]
Sci RepOsteoporosis is a chronic metabolic bone disease that is prone to fractures. Isoimperatorin (ISO) has been shown to alleviate the bone loss in ovariectomized (OVX) rats. The aim of this study was to investigate the effect and the mechanism of ISO on osteoporosis using animal study and cell experiments.
Hu G, Wen J, Yang H, Zhang K.
europepmc +4 more sources
NSUN2-mediated m5C modification of SOCS3 mRNA modulates macrophage polarization in bladder cancer. [PDF]
Cell Death DisAbstract Background: Tumor-associated macrophages (TAMs) are pivotal in facilitating the progression of cancer cells. M1 and M2 are two polarization states of TAMs with opposite functions in tumor progression. Recent studies have revealed the regulatory roles of N6-adenosine (m6A) RNA methylation in the direction of macrophage polarization, but
Tang Y +11 more
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ALYREF mediates RNA m5C modification to promote hepatocellular carcinoma progression. [PDF]
Signal Transduct Target Ther, 2023 Xue C +9 more
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Prediction of m5C Modifications in RNA Sequences by Combining Multiple Sequence Features [PDF]
Molecular Therapy Nucleic Acids, 2020 5-Methylcytosine (m5C) is a well-known post-transcriptional modification that plays significant roles in biological processes, such as RNA metabolism, tRNA recognition, and stress responses. Traditional high-throughput techniques on identification of m5C sites are usually time consuming and expensive.
Lijun Dou +4 more
openaire +3 more sources