Results 21 to 30 of about 5,548 (154)

P1250: TRNA METHYLTRANSFERASE DNMT2 MODULATES GVHD PROCESS VIA TRNA M5C MODIFICATION [PDF]

Hemasphere, 2023
Chao M, Guo H, Wang R, Chen T, Zeng Y, Wu S, Yang S, Zhang Y, Zhang X.   +8 more
europepmc   +3 more sources

m5C Regulator-Mediated Methylation Modification Patterns and Tumor Microenvironment Infiltration Characterization in Papillary Thyroid Carcinoma

Frontiers in Oncology, 2021
Recently, immune response modulation at the epigenetic level is illustrated in studies, but the possible function of RNA 5-methylcytosine (m5C) modification in cell infiltration within the tumor microenvironment (TME) is still unclear.
Fei Li, Qingmei Deng, Xiaoxi Pang, Shan Huang, Jingmiao Zhang, Xiaxia Zhu, Hong Chen, Xiuxia Liu   +7 more
doaj   +1 more source

Identification of the Expression Patterns and Potential Prognostic Role of 5-Methylcytosine Regulators in Hepatocellular Carcinoma

Frontiers in Cell and Developmental Biology, 2022
Background: Hepatocellular carcinoma (HCC) is the most common primary liver cancer with a poor prognosis. 5-methylcytosine (m5C) modification plays a nonnegligible role in tumor pathogenesis and progression. However, little is known about the role of m5C
Yong Liu, Shunzhen Zheng, Tao Wang, Ziqi Fang, Junjie Kong, Junjie Kong, Jun Liu, Jun Liu   +7 more
doaj   +1 more source

The RNA Methylation Modification 5-Methylcytosine Impacts Immunity Characteristics, Prognosis and Progression of Oral Squamous Cell Carcinoma by Bioinformatics Analysis

Frontiers in Bioengineering and Biotechnology, 2021
Disorders pertaining to 5-methylcytosine (m5C) modifications are involved in the pathological process of many diseases. However, the effect of m5C on the tumorigenesis and progression of oral squamous cell carcinoma (OSCC) remains unclear. In this study,
Li Gao, Ru Chen, Masahiro Sugimoto, Masanobu Mizuta, Lei Zhou, Yo Kishimoto, Xinsheng Huang, Koichi Omori   +7 more
doaj   +1 more source

m5C regulator-mediated methylation modification phenotypes characterized by distinct tumor microenvironment immune heterogenicity in colorectal cancer

Scientific Reports, 2023
The RNA 5-methylcytosine (m5C) modification has been demonstrated to be an important epigenetic regulator and to impact colorectal cancer (CRC) progression.
Zhihua Chen, Quanfa Li, Yilin Lin, Suyong Lin, Ji Gao, Shaoqin Chen   +5 more
doaj   +1 more source

Roles of m5C RNA Modification Patterns in Biochemical Recurrence and Tumor Microenvironment Characterization of Prostate Adenocarcinoma

Frontiers in Immunology, 2022
BackgroundProstate cancer is the second most common cancer with a high risk of biochemical recurrence (BCR) among men. Recently, 5-methylcytosine (m5C) modification has attracted more attention as a new layer of RNA post-transcriptional regulation. Hence,
Zhipeng Xu, Zhipeng Xu, Shuqiu Chen, Shuqiu Chen, Yuxi Zhang, Ruiji Liu, Ruiji Liu, Ruiji Liu, Ming Chen, Ming Chen, Ming Chen   +10 more
doaj   +1 more source

Dynamics of RNA m⁵C modification during brain development. [PDF]

Genomics, 2023
Post-transcriptional RNA modifications have been recognized as key regulators of neuronal differentiation and synapse development in the mammalian brain. While distinct sets of 5-methylcytosine (m5C) modified mRNAs have been detected in neuronal cells and brain tissues, no study has been performed to characterize methylated mRNA profiles in the ...
Johnson Z, Xu X, Lin Y, Xie H.
europepmc   +4 more sources

Vital roles of m5C RNA modification in cancer and immune cell biology

Frontiers in Immunology, 2023
RNA modification plays an important role in epigenetics at the posttranscriptional level, and 5-methylcytosine (m5C) has attracted increasing attention in recent years due to the improvement in RNA m5C site detection methods. By influencing transcription,
Xinyu Gu, Xiao Ma, Chao Chen, Jun Guan, Jing Wang, Shanshan Wu, Haihong Zhu   +6 more
doaj   +1 more source

RNA m5C regulator-mediated modification patterns and the cross-talk between tumor microenvironment infiltration in gastric cancer

Frontiers in Immunology, 2022
The effect of immunotherapy strategy has been affirmed in the treatment of various tumors. Nevertheless, the latent role of RNA 5-methylcytosine (m5C) modification in gastric cancer (GC) tumor microenvironment (TME) cell infiltration is still unclear. We
Qiang Zhang, Qiang Zhang, Xiangfei Sun, Jianyi Sun, Jiangshen Lu, Xiaodong Gao, Kuntang Shen, Xinyu Qin   +7 more
doaj   +1 more source

Identification of Expression Patterns and Potential Prognostic Significance of m5C-Related Regulators in Head and Neck Squamous Cell Carcinoma

Frontiers in Oncology, 2021
5-Methylcytosine (m5C) methylation is a major epigenetic technique of RNA modification and is dynamically mediated by m5C “writers,” “erasers,” and “readers.” m5C RNA modification and its regulators are implicated in the onset and development of many ...
Zhenyuan Han, Zhenyuan Han, Biao Yang, Yu Wang, Yu Wang, Xiuxia Zeng, Zhen Tian   +6 more
doaj   +1 more source