Results 31 to 40 of about 5,548 (154)

CX3CL1 promotes M1 macrophage polarization and osteoclast differentiation via NSUN5-mediated m5C modification. [PDF]

Sci Rep
Bone homeostasis refers to a dynamic equilibrium maintained between osteogenesis and osteoclastic bone resorption within the skeletal system. CX3CL1 (Fractalkine) is a chemokine that plays a significant regulatory role in bone homeostasis. This study aimed to investigate the mechanisms by which CX3CL1 regulates bone homeostasis.
Deng Z, Zhong W.
europepmc   +2 more sources

The lncRNA epigenetics: The significance of m6A and m5C lncRNA modifications in cancer

Frontiers in Oncology, 2023
Most of our transcribed RNAs are represented by non-coding sequences. Long non-coding RNAs (lncRNAs) are transcripts with no or very limited protein coding ability and a length >200nt. They can be epigenetically modified. N6-methyladenosine (m6A), N1-methyladenosine (m1A), 5-methylcytosine (m5C), 7-methylguanosine (m7G) and 2’-O-methylation (Nm)
Vincenza Ylenia Cusenza, Annalisa Tameni, Antonino Neri, Raffaele Frazzi   +3 more
openaire   +3 more sources

Folate regulates RNA m⁵C modification and translation in neural stem cells. [PDF]

BMC Biol, 2022
Abstract Background Folate is an essential B-group vitamin and a key methyl donor with important biological functions including DNA methylation regulation. Normal neurodevelopment and physiology are sensitive to the cellular folate levels. Either deficiency or excess of folate may lead to neurological disorders. Recently,
Xu X, Johnson Z, Wang A, Padget RL, Smyth JW, Xie H.   +5 more
europepmc   +5 more sources

Identification of m5C-related molecular subtypes and prediction models in the prognosis and tumor microenvironment infiltration of soft tissue sarcoma

Heliyon, 2023
Background: The epigenetic regulator in cancer progression and immune response has been demonstrated recently. However, the potential implications of 5-methylcytosine (m5C) in soft tissue sarcoma (STS) are unclear.
Xianfeng Wang, Yicheng Mao, Hanlu Xu, Jiyang Chen, Xiao chen   +4 more
doaj   +1 more source

Developmental mRNA m5C landscape and regulatory innovations of massive m5C modification of maternal mRNAs in animals

Nature Communications, 2022
Abstractm5C is one of the longest-known RNA modifications, however, its developmental dynamics, functions, and evolution in mRNAs remain largely unknown. Here, we generate quantitative mRNA m5C maps at different stages of development in 6 vertebrate and invertebrate species and find convergent and unexpected massive methylation of maternal mRNAs ...
Jianheng Liu, Tao Huang, Wanying Chen, Chenhui Ding, Tianxuan Zhao, Xueni Zhao, Bing Cai, Yusen Zhang, Song Li, Ling Zhang, Maoguang Xue, Xiuju He, Wanzhong Ge, Canquan Zhou, Yanwen Xu, Rui Zhang   +15 more
openaire   +3 more sources

Aberrant m5C hypermethylation mediates intrinsic resistance to gefitinib through NSUN2/YBX1/QSOX1 axis in EGFR-mutant non-small-cell lung cancer

Molecular Cancer, 2023
Background RNA 5-methylcytosine (m5C) modification plays critical roles in the pathogenesis of various tumors. However, the function and molecular mechanism of RNA m5C modification in tumor drug resistance remain unclear.
Yueqin Wang, Jingyao Wei, Luyao Feng, Ouwen Li, Lan Huang, Shaoxuan Zhou, Yingjie Xu, Ke An, Yu Zhang, Ruiying Chen, Lulu He, Qiming Wang, Han Wang, Yue Du, Ruijuan Liu, Chunmin Huang, Xiaojian Zhang, Yun-gui Yang, Quancheng Kan, Xin Tian   +19 more
doaj   +1 more source

Comprehensive Analysis of 5-Methylcytosine (m5C) Regulators and the Immune Microenvironment in Pancreatic Adenocarcinoma to Aid Immunotherapy

Frontiers in Oncology, 2022
BackgroundPancreatic adenocarcinoma (PAAD) is one of the most malignant cancers and has a poor prognosis. As a critical RNA modification, 5-methylcytosine (m5C) has been reported to regulate tumor progression, including PAAD progression.
Ronglin Wang, Yongdong Guo, Peixiang Ma, Yang Song, Jie Min, Ting Zhao, Lei Hua, Chao Zhang, Cheng Yang, Jingjie Shi, Liaoliao Zhu, Dongxue Gan, Shanshan Li, Junqiang Li, Haichuan Su   +14 more
doaj   +1 more source

Molecular Characterization and Clinical Characteristics of m5C-Based RNA Methylation in Spinal Cord Injury: Validated by qPCR

International Journal of Genomics, 2022
Aberrant patterns of 5-methylcytosine (m5C)-based ribonucleic acid (RNA) methylation have critical roles in various human diseases, but their importance in spinal cord injury (SCI) is largely unknown.
Liang Cao, Wen Jun Pi, Qiang Zhang, Qing Li   +3 more
doaj   +1 more source

FMRP promotes transcription-coupled homologous recombination via facilitating TET1-mediated m5C RNA modification demethylation

Proceedings of the National Academy of Sciences, 2022
Significance This study shows that Fragile X mental retardation protein (FMRP) promotes messenger RNA (mRNA)-dependent recombination via facilitating ten-eleven translocation protein 1 (TET1)-mediated mRNA methyl-5-cytosine (m5C) demethylation.
Haibo Yang, Yumin Wang, Yufei Xiang, Tribhuwan Yadav, Jian Ouyang, Laiyee Phoon, Xueping Zhu, Yi Shi, Lee Zou, Li Lan   +9 more
openaire   +2 more sources

Small‐Molecule Activation of mRNA Translation by Click‐to‐Release Reaction in Cells

Angewandte Chemie, EarlyView.
A new method to control mRNA activity using bioorthogonal click‐to‐release reactions is presented. The 5′ cap is modified with a trans‐cyclooctene (TCO) that quickly reacts with hydroxyaryl‐tetrazines and efficiently releases the native cap 0. TCO‐capped mRNAs are initially translationally inactive but can be activated with non‐toxic, cell‐permeable ...
Tess Vosman, Friedrich Burba, Martin Sumser, Milan Vrabel, Hannes Mikula, Andrea Rentmeister   +5 more
wiley   +2 more sources