Results 1 to 10 of about 57,651 (173)

Mitochondrial fission factor (MFF) frameshift variant in Bullmastiffs with mitochondrial fission encephalopathy. [PDF]

Anim Genet, 2022
AbstractFamilial cerebellar ataxia with hydrocephalus in Bullmastiffs was described almost 40 years ago as a monogenic autosomal recessive trait. We investigated two young Bullmastiffs showing similar clinical signs. They developed progressive gait and behavioural abnormalities with an onset at around 6 months of age.
Christen M, Gutierrez-Quintana R, Vandenberghe H, Kaczmarska A, Penderis J, José-López R, Rupp A, Griffiths IR, Jagannathan V, Leeb T.   +9 more
europepmc   +4 more sources

Mitochondrial fission factor promotes cisplatin resistancein hepatocellular carcinoma. [PDF]

Acta Biochim Biophys Sin (Shanghai), 2022
Hepatocellular carcinoma (HCC) is the most common primary liver tumor and one of the leading causes of cancer-related death worldwide. Chemotherapeutic agents/regimens such as cisplatin (DDP) are frequently used for advanced HCC treatment. However, drug resistance remains a major hindrance and the underline mechanisms are not fully understood.
Li X, Wu Q, Ma F, Zhang X, Cai L, Yang X.   +5 more
europepmc   +5 more sources

Nanobodies as novel tools to monitor the mitochondrial fission factor Drp1. [PDF]

Life Sci Alliance, 2023
In cells, mitochondria undergo constant fusion and fission. An essential factor for fission is the mammalian dynamin-related protein 1 (Drp1). Dysregulation of Drp1 is associated with neurodegenerative diseases including Parkinson’s, cardiovascular diseases and cancer, making Drp1 a pivotal biomarker for monitoring mitochondrial status and potential ...
Froehlich T, Jenner A, Cavarischia-Rega C, Fagbadebo FO, Lurz Y, Frecot DI, Kaiser PD, Nueske S, Scholz AM, Schäffer E, Garcia-Saez AJ, Macek B, Rothbauer U.   +12 more
europepmc   +5 more sources

Mitochondrial fission factor (Mff) is required for organization of the mitochondrial sheath in spermatids. [PDF]

Biochim Biophys Acta Gen Subj, 2021
Mitochondrial fission counterbalances fusion to maintain organelle morphology, but its role during development remains poorly characterized. Mammalian spermatogenesis is a complex developmental process involving several drastic changes to mitochondrial shape and organization.
Varuzhanyan G, Chen H, Rojansky R, Ladinsky MS, McCaffery JM, Chan DC.   +5 more
europepmc   +5 more sources

Mitochondrial Fission Factor Gene Mutation: A Dilemma for Prenatal Diagnosis.

Int J Appl Basic Med Res, 2021
Mitochondrial fission factor (MFF) gene mutations are rare mitochondrial fission disorders, resulting in autosomal recessive neurological disorders. We here report a rare case of MFF gene mutation running in a family which ultimately turned out to be a variant of unknown significance. A 29-year-old multigravida visited at 18-week gestation for prenatal
Sharma C, Saini A, Gothwal M, Jhirwal M, Patwa P.   +4 more
europepmc   +4 more sources

Mitochondrial fission factor is a novel Myc-dependent regulator of mitochondrial permeability in cancer. [PDF]

EBioMedicine, 2019
Mitochondrial functions are exploited in cancer and provide a validated therapeutic target. However, how this process is regulated has remained mostly elusive and the identification of new pathways that control mitochondrial integrity in cancer is an urgent priority.We studied clinically-annotated patient series of primary and metastatic prostate ...
Seo JH, Agarwal E, Chae YC, Lee YG, Garlick DS, Storaci AM, Ferrero S, Gaudioso G, Gianelli U, Vaira V, Altieri DC.   +10 more
europepmc   +8 more sources

Mitochondrial Fission Factor (MFF) Inhibits Mitochondrial Metabolism and Reduces Breast Cancer Stem Cell (CSC) Activity. [PDF]

Front Oncol, 2020
Elevated mitochondrial biogenesis and metabolism represent key features of breast cancer stem cells (CSCs), whose propagation is conducive to disease onset and progression. Therefore, interfering with mitochondria biology and function may be regarded as a useful approach to eradicate CSCs.
Sánchez-Alvarez R, De Francesco EM, Fiorillo M, Sotgia F, Lisanti MP.   +4 more
europepmc   +8 more sources

Mitochondrial fission factor (MFF) is a critical regulator of peroxisome maturation.

Biochim Biophys Acta Mol Cell Res, 2020
AbstractPeroxisomes are highly dynamic subcellular compartments with important functions in lipid and ROS metabolism. Impaired peroxisomal function can lead to severe metabolic disorders with developmental defects and neurological abnormalities. Recently, a new group of disorders has been identified, characterised by defects in the membrane dynamics ...
Passmore JB, Carmichael RE, Schrader TA, Godinho LF, Ferdinandusse S, Lismont C, Wang Y, Hacker C, Islinger M, Fransen M, Richards DM, Freisinger P, Schrader M.   +12 more
europepmc   +7 more sources

PEX11β and FIS1 cooperate in peroxisome division independently of mitochondrial fission factor.

J Cell Sci, 2022
ABSTRACT Peroxisome membrane dynamics and division are essential to adapt the peroxisomal compartment to cellular needs. The peroxisomal membrane protein PEX11β (also known as PEX11B) and the tail-anchored adaptor proteins FIS1 (mitochondrial fission protein 1) and MFF (mitochondrial fission factor), which recruit the fission GTPase DRP1
Schrader TA, Carmichael RE, Islinger M, Costello JL, Hacker C, Bonekamp NA, Weishaupt JH, Andersen PM, Schrader M.   +8 more
europepmc   +5 more sources

Mitochondrial fission factor drives an actionable metabolic vulnerability in multiple myeloma. [PDF]

Haematologica
Proliferating multiple myeloma (MM) cells in the bone marrow fluctuate across various metabolic states to resist cancer treatments. Herein, we investigate how mitochondrial dynamics, which controls mitochondrial fitness via coordinated fission and fusion events, shapes MM cell metabolism impacting growth, survival and drug sensitivity. We identify MFF (
Cantafio MEG, Valentino I, Torcasio R, Ganino L, Veneziano C, Murfone P, Mesuraca M, Perrotta I, Tallarigo F, Agosti V, De Marco C, Pasqua T, Giallongo C, Cappello AR, Fiorillo M, Gentile M, Tibullo D, Viglietto G, Neri A, Amodio N.   +19 more
europepmc   +4 more sources