Results 11 to 20 of about 57,770 (292)

Identification of elongation factor‐2 as a novel regulator of mitochondrial fission [PDF]

Natural Sciences, 2022
Mitochondria continuously undergo morphologically dynamic processes of fusion and fission to maintain their size, shape, amount, and function; yet the precise molecular mechanisms by which mitochondrial dynamics is regulated remain to be fully elucidated.
Jinhwan Kim, Yanfeng Li, Yan Cheng, Xingcong Ren, Yi Zhang, Cheng Ji, Hua Zhu, Yoshinori Takahashi, Xingdong Xiong, Lixiang Gu, Chrispus Ngule, Xiaofang Xiong, Jianxun Song, Xiaoqi Liu, Jin‐Ming Yang   +14 more
doaj   +2 more sources

Non-alcoholic fatty liver disease in mice with hepatocyte-specific deletion of mitochondrial fission factor. [PDF]

Diabetologia, 2021
Abstract Aims/hypothesis Mitochondria are highly dynamic organelles continuously undergoing fission and fusion, referred to as mitochondrial dynamics, to adapt to nutritional demands. Evidence suggests that impaired mitochondrial dynamics leads to metabolic abnormalities such as non-alcoholic steatohepatitis (NASH ...
Takeichi Y, Miyazawa T, Sakamoto S, Hanada Y, Wang L, Gotoh K, Uchida K, Katsuhara S, Sakamoto R, Ishihara T, Masuda K, Ishihara N, Nomura M, Ogawa Y.   +13 more
europepmc   +4 more sources

The mitochondrial fission factor FIS1 promotes stemness of human lung cancer stem cells via mitophagy. [PDF]

FEBS Open Bio, 2021
Mitophagy, a form of autophagy, plays a role in cancer development, progression and recurrence. Cancer stem cells (CSCs) also play a key role in these processes, although it not known whether mitophagy can regulate the stemness of CSCs. Here, we employed the A549‐SD human non‐small cell lung adenocarcinoma CSC model that we have developed and ...
Liu D, Sun Z, Ye T, Li J, Zeng B, Zhao Q, Wang J, Xing HR.   +7 more
europepmc   +5 more sources

microRNA-200a-3p enhances mitochondrial elongation by targeting mitochondrial fission factor. [PDF]

BMB Rep, 2017
Mitochondria play pivotal roles in the ATP production, apoptosis and generation of reactive oxygen species. Although dynamic regulation of mitochondria morphology is a critical step to maintain cellular homeostasis, the regulatory mechanisms are not yet fully elucidated.
Lee H, Tak H, Park SJ, Jo YK, Cho DH, Lee EK.   +5 more
europepmc   +5 more sources

Parkin-mediated ubiquitination contributes to the constitutive turnover of mitochondrial fission factor (Mff). [PDF]

PLoS One, 2019
The mitochondrial outer membrane protein Mitochondrial Fission Factor (Mff) plays a key role in both physiological and pathological fission. It is well established that at stressed or functionally impaired mitochondria, PINK1 recruits the ubiquitin ligase Parkin which ubiquitinates Mff and other mitochondrial outer membrane proteins to facilitate the ...
Lee L, Seager R, Nakamura Y, Wilkinson KA, Henley JM.   +4 more
europepmc   +8 more sources

Clinical and Biochemical Features in a Patient With Mitochondrial Fission Factor Gene Alteration. [PDF]

Front Genet, 2018
Mitochondrial Fission Factor (MFF) is part of a protein complex that promotes mitochondria and peroxisome fission. Hitherto, only 5 patients have been reported harboring mutations in MFF, all of them with the clinical features of a very early onset Leigh-like encephalopathy. We report on an 11-year-old boy with epileptic encephalopathy.
Nasca A, Nardecchia F, Commone A, Semeraro M, Legati A, Garavaglia B, Ghezzi D, Leuzzi V.   +7 more
europepmc   +5 more sources

Removal of the Mitochondrial Fission Factor Mff Exacerbates Neuronal Loss and Neurological Phenotypes in a Huntington's Disease Mouse Model. [PDF]

PLoS Curr, 2018
Objective: Excessive mitochondrial fission has been associated with several neurodegenerative diseases, including Huntington’s disease (HD). Consequently, mitochondrial dynamics has been suggested to be a promising therapeutic target for Huntington’s ...
Cha MY, Chen H, Chan D.
europepmc   +2 more sources

Interaction of mitochondrial fission factor with dynamin related protein 1 governs physiological mitochondrial function in vivo. [PDF]

Sci Rep, 2018
AbstractMitochondria form a dynamic network governed by a balance between opposing fission and fusion processes. Because excessive mitochondrial fission correlates with numerous pathologies, including neurodegeneration, the mechanism governing fission has become an attractive therapeutic strategy.
Kornfeld OS, Qvit N, Haileselassie B, Shamloo M, Bernardi P, Mochly-Rosen D.   +5 more
europepmc   +5 more sources

Mitochondrial fission factor: a living way for mitochondria sensing food. [PDF]

MedComm (2020)
Zhi M, Cao R, Fu X, Li L.
europepmc   +4 more sources

A PKD-MFF signaling axis couples mitochondrial fission to mitotic progression

Cell Reports, 2021
Summary: Mitochondria are highly dynamic organelles subjected to fission and fusion events. During mitosis, mitochondrial fission ensures equal distribution of mitochondria to daughter cells. If and how this process can actively drive mitotic progression
Evanthia Pangou, Olga Bielska, Lucile Guerber, Stephane Schmucker, Arantxa Agote-Arán, Taozhi Ye, Yongrong Liao, Marta Puig-Gamez, Erwan Grandgirard, Charlotte Kleiss, Yansheng Liu, Emmanuel Compe, Zhirong Zhang, Ruedi Aebersold, Romeo Ricci, Izabela Sumara   +15 more
doaj   +1 more source