Results 21 to 30 of about 57,770 (292)
TRAP1 controls mitochondrial fusion/fission balance through Drp1 and Mff expression. [PDF]
PLoS ONE, 2012 Mitochondria are dynamic organelles that change in response to extracellular stimuli. These changes are essential for normal mitochondrial/cellular function and are controlled by a tight balance between two antagonistic pathways that promote fusion and ...
Hironori Takamura +8 more
doaj +1 more source
Nature Communications, 2023 Mitochondrial morphology, which is controlled by mitochondrial fission and fusion, is an important regulator of the thermogenic capacity of brown adipocytes.
Donghua Hu +11 more
doaj +1 more source
New therapeutic directions in type II diabetes and its complications: mitochondrial dynamics
Frontiers in Endocrinology, 2023 As important organelles of energetic and metabolism, changes in the dynamic state of mitochondria affect the homeostasis of cellular metabolism. Mitochondrial dynamics include mitochondrial fusion and mitochondrial fission.
Shengnan Wang +7 more
doaj +1 more source
miR-761 regulates the mitochondrial network by targeting mitochondrial fission factor [PDF]
Free Radical Biology and Medicine, 2013 Mitochondria are dynamic organelles that constantly undergo fission and fusion. The balance between fission and fusion determines the fate of the cell. In this study, we show that mitochondrial fission factor (MFF) is upregulated upon hydrogen peroxide treatment or ischemia/reperfusion (I/R) injury.
Bo, Long +9 more
openaire +2 more sources
miR-27 regulates mitochondrial networks by directly targeting the mitochondrial fission factor [PDF]
Experimental & Molecular Medicine, 2014 Mitochondrial morphology is dynamically regulated by forming small, fragmented units or interconnected networks, and this is a pivotal process that is used to maintain mitochondrial homeostasis. Although dysregulation of mitochondrial dynamics is related to the pathogenesis of several human diseases, its molecular mechanism is not fully elucidated.
Tak, Hyosun +9 more
openaire +2 more sources
PLoS Genetics, 2020 Balanced mitochondrial fission and fusion play an important role in shaping and distributing mitochondria, as well as contributing to mitochondrial homeostasis and adaptation to stress.
Ana Terriente-Felix +2 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Although mitochondrial fission has been reported to increase proliferative capacity and collagen production, it can also contribute to mitochondrial impairment, which is detrimental to cell survival.
Qing-Yuan Gao +26 more
doaj +1 more source
FEBS Open Bio, 2021 Hypoxia is a risk factor for Alzheimer's disease (AD). Besides, mitochondrial fission is increased in response to hypoxia. In this study, we sought to investigate whether hypoxia‐induced mitochondrial fission plays a critical role in regulating amyloid‐β
Yuan Yuan +6 more
doaj +1 more source
The Imbalance of Mitochondrial Fusion/Fission Drives High-Glucose-Induced Vascular Injury
Biomolecules, 2021 Emerging evidence shows that mitochondria fusion/fission imbalance is related to the occurrence of hyperglycemia-induced vascular injury. To study the temporal dynamics of mitochondrial fusion and fission, we observed the alteration of mitochondrial ...
Yunsi Zheng, Anqi Luo, Xiaoquan Liu
doaj +1 more source
Nucleic Acid Therapeutics, 2022 Mitochondria are highly dynamic organelles that produce ATP and maintain metabolic, catabolic, and redox homeostasis. Mitochondria owe this dynamic nature to their constant fission and fusion-processes that are regulated, in part, by fusion factors (MFN1 and MFN2) and fission factors (DRP1, FIS1, MFF, MIEF1, MIEF2) located on the outer mitochondrial ...
Daniel A. Garcia +4 more
openaire +2 more sources