Frontiers in Cell and Developmental Biology, 2022 High-fat diet (HFD)-induced obesity has become the major risk factor for the development of cardiovascular diseases, but the underlying mechanisms remain poorly understood.
Peiduo Liu +3 more
doaj +1 more source
AMP-activated protein kinase mediates mitochondrial fission in response to energy stress [PDF]
, 2016 Mitochondria undergo fragmentation in response to electron transport chain (ETC) poisons and mitochondrial DNA–linked disease mutations, yet how these stimuli mechanistically connect to the mitochondrial fission and fusion machinery is poorly understood.
Chan, David C. +10 more
core +4 more sources
Journal of Pharmacological Sciences, 2023 Differentiation-inducing factor 1 (DIF-1) is a morphogen produced by Dictyostelium discoideum that inhibits the proliferation and migration of both D. discoideum and most mammalian cells.
Takeru Inoue +7 more
doaj +1 more source
High glucose–induced ROS activates TRPM2 to trigger lysosomal membrane permeabilization and Zn2+-mediated mitochondrial fission [PDF]
, 2017 Diabetic stress increases the production of reactive oxygen species (ROS), leading to mitochondrial fragmentation and dysfunction. Wehypothesized that ROS-sensitive TRPM2 channels mediated diabetic stress–induced mitochondrial fragmentation.
Asipu Sivaprasadarao +6 more
core +1 more source
Mitochondrial dynamics in type 2 diabetes: Pathophysiological implications
Redox Biology, 2017 Mitochondria play a key role in maintaining cellular metabolic homeostasis. These organelles have a high plasticity and are involved in dynamic processes such as mitochondrial fusion and fission, mitophagy and mitochondrial biogenesis. Type 2 diabetes is
Susana Rovira-Llopis +5 more
doaj +1 more source
Mitochondrial dynamics–fusion, fission, movement, and mitophagy–in neurodegenerative diseases [PDF]
, 2009 Neurons are metabolically active cells with high energy demands at locations distant from the cell body. As a result, these cells are particularly dependent on mitochondrial function, as reflected by the observation that diseases of mitochondrial ...
Alexander +42 more
core +3 more sources
Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells [PDF]
Journal of Cell Biology, 2010 The cytoplasmic dynamin-related guanosine triphosphatase Drp1 is recruited to mitochondria and mediates mitochondrial fission. Although the mitochondrial outer membrane (MOM) protein Fis1 is thought to be a Drp1 receptor, this has not been confirmed. To analyze the mechanism of Drp1 recruitment, we manipulated the expression of mitochondrial fission ...
Otera, Hidenori +6 more
openaire +2 more sources
Klf5 down-regulation induces vascular senescence through eIF5a depletion and mitochondrial fission.
PLoS Biology, 2020 Although dysregulation of mitochondrial dynamics has been linked to cellular senescence, which contributes to advanced age-related disorders, it is unclear how Krüppel-like factor 5 (Klf5), an essential transcriptional factor of cardiovascular remodeling,
Dong Ma +9 more
doaj +1 more source
Fis1 phosphorylation by Met promotes mitochondrial fission and hepatocellular carcinoma metastasis
Signal Transduction and Targeted Therapy, 2021 Met tyrosine kinase, a receptor for a hepatocyte growth factor (HGF), plays a critical role in tumor growth, metastasis, and drug resistance. Mitochondria are highly dynamic and undergo fission and fusion to maintain a functional mitochondrial network ...
Yan Yu +20 more
doaj +1 more source
Emerging functions of mammalian mitochondrial fusion and fission [PDF]
, 2005 Mitochondria provide a myriad of services to the cell, including energy production, calcium buffering and regulation of apoptosis. How these diverse functions are coordinated among the hundreds of mitochondria in a given cell is largely unknown, but is ...
Chan, David C., Chen, Hsiuchen
core +1 more source