Results 71 to 80 of about 3,511 (107)

N¹-Methyladenosine modification of mRNA regulates neuronal gene expression and oxygen glucose deprivation/reoxygenation induction. [PDF]

Cell Death Discov, 2023
Qi Z, Zhang C, Jian H, Hou M, Lou Y, Kang Y, Wang W, Lv Y, Shang S, Wang C, Li X, Feng S, Zhou H.   +12 more
europepmc   +1 more source

Unravelling the impact of RNA methylation genetic and epigenetic machinery in the treatment of cardiomyopathy

Pharmacological Research
Cardiomyopathy (CM) represents a heterogeneous group of diseases primarily affecting cardiac structure and function, with genetic and epigenetic dysregulation playing a pivotal role in its pathogenesis.
Li Liu, Linxing Yu, Yubo Wang, Liufang Zhou, Yan Liu, Xingshou Pan, Jianjun Huang   +6 more
doaj   +1 more source

RNA m1A methyltransferase TRMT61A promotes colorectal tumorigenesis by enhancing ONECUT2 mRNA stability and is a potential therapeutic target

Cancer Communications
Background The role of N1‐methyladenosine (m1A) in cancer is poorly understood. Here we explored the function of RNA methyltransferase TRNA methyltransferase 61A (TRMT61A) in colorectal cancer (CRC) and its potential as a therapeutic target.
Xiaoting Zhang, Na Qin, Fenfen Ji, Hao Su, Haiyun Shang, Hongyan Chen, Dan Huang, Qing Li, Jing Ren, Weixin Liu, Yifei Wang, Wei Kang, Jiabin Wu, Chi‐Chun Wong, Zongwei Cai, Matthew Tak Vai Chan, William Ka Kei Wu, Jun Yu, Huarong Chen   +18 more
doaj   +1 more source

N¹-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism. [PDF]

Nat Commun, 2021
Wang Y, Wang J, Li X, Xiong X, Wang J, Zhou Z, Zhu X, Gu Y, Dominissini D, He L, Tian Y, Yi C, Fan Z.   +12 more
europepmc   +1 more source

ALKBH3‐Mediated M1A Demethylation of METTL3 Endows Pathological Fibrosis:Interplay Between M1A and M6A RNA Methylation

Advanced Science
Epigenetic modifications serve as crucial molecular switches for pathological fibrosis; howbeit the role of m1A in this condition remains enigmatic. Herein, it is found that ALKBH3 exerts a pro‐fibrotic effect in pathological skin fibrosis by reshaping ...
Liying Tu, Shuchen Gu, Ruoqing Xu, En Yang, Xin Huang, Hsin Liang, Shenying Luo, Haizhou Li, Yixuan Zhao, Tao Zan   +9 more
doaj   +1 more source

Writers, readers, and erasers RNA modifications and drug resistance in cancer

Molecular Cancer
Drug resistance in cancer cells significantly diminishes treatment efficacy, leading to recurrence and metastasis. A critical factor contributing to this resistance is the epigenetic alteration of gene expression via RNA modifications, such as N6 ...
Di Chen, Xinyu Gu, Yeltai Nurzat, Lixia Xu, Xueyuan Li, Lixin Wu, Henan Jiao, Peng Gao, Xuqiang Zhu, Dongming Yan, Shaohua Li, Chen Xue   +11 more
doaj   +1 more source

The Arabidopsis TRM61/TRM6 complex is a bona fide tRNA N1-methyladenosine methyltransferase. [PDF]

J Exp Bot, 2020
Tang J, Jia P, Xin P, Chu J, Shi DQ, Yang WC.   +5 more
europepmc   +1 more source

Deprotection of N1-methyladenosine-containing RNA using triethylamine hydrogen fluoride. [PDF]

Nucleosides Nucleotides Nucleic Acids
Apostle A, Fang S.
europepmc   +1 more source

A Fluorescent Aptasensor for Sensitive and Selective Determination of Epigenetic Cancer Biomarker N¹-Methyladenosine in Urine Samples. [PDF]

Chemistry
Bağda E, Bağda E, Liu J.
europepmc   +1 more source