Results 41 to 50 of about 3,551 (133)

Emerging roles of RNA methylation in gastrointestinal cancers

Cancer Cell International, 2020
RNA methylation has emerged as a fundamental process in epigenetic regulation. Accumulating evidences indicate that RNA methylation is essential for many biological functions, and its dysregulation is associated with human cancer progression ...
Shanshan Xie, Wenwen Chen, Kanghua Chen, Yongxia Chang, Feng Yang, Aifu Lin, Qiang Shu, Tianhua Zhou, Xiaoyi Yan   +8 more
doaj   +1 more source

Roles of Major RNA Adenosine Modifications in Head and Neck Squamous Cell Carcinoma

Frontiers in Pharmacology, 2021
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer malignancy worldwide and is known to have poor prognosis. The pathogenesis behind the development of HNSCC is not fully understood.
Xing-xing Huo, Xing-xing Huo, Shu-jie Wang, Hang Song, Ming-de Li, Hua Yu, Meng Wang, Hong-xiao Gong, Xiao-ting Qiu, Yong-fu Zhu, Jian-ye Zhang   +10 more
doaj   +1 more source

The role of RNA modification in hepatocellular carcinoma

Frontiers in Pharmacology, 2022
Hepatocellular carcinoma (HCC) is a highly mortal type of primary liver cancer. Abnormal epigenetic modifications are present in HCC, and RNA modification is dynamic and reversible and is a key post-transcriptional regulator.
Qiang Feng, Dongxu Wang, Tianyi Xue, Chao Lin, Yongjian Gao, Liqun Sun, Ye Jin, Dianfeng Liu   +7 more
doaj   +1 more source

Research advances of mRNA methylation in kidney diseases

Linchuang shenzangbing zazhi
Recently mRNA methylation modification has been extensively examined, including N6-methyladenosine (m6A), N5-methylcytidine (m5C) and N1-methyladenosine (m1A).
Shi-wen Zhang, Jun-jun Luan, Hua Zhou
doaj   +1 more source

Insights into the regulatory role of RNA methylation modifications in glioma

Journal of Translational Medicine, 2023
Epitranscriptomic abnormalities, which are highly prevalent in primary central nervous system malignancies, have been identified as crucial contributors to the development and progression of gliomas.
Shengrong Long, Yu Yan, Hongyu Xu, Lesheng Wang, Jiazhi Jiang, Ziyue Xu, Runming Liu, Qiangqiang Zhou, Xiaopeng Huang, Jincao Chen, Zhiqiang Li, Wei Wei, Xiang Li   +12 more
doaj   +1 more source

Epigenetics: Roles and therapeutic implications of non-coding RNA modifications in human cancers

Molecular Therapy: Nucleic Acids, 2021
As next-generation sequencing (NGS) is leaping forward, more than 160 covalent RNA modification processes have been reported, and they are widely present in every organism and overall RNA type.
Dawei Rong, Guangshun Sun, Fan Wu, Ye Cheng, Guoqiang Sun, Wei Jiang, Xiao Li, Yi Zhong, Liangliang Wu, Chuanyong Zhang, Weiwei Tang, Xuehao Wang   +11 more
doaj   +1 more source

Novel insight into the regulatory roles of diverse RNA modifications: Re-defining the bridge between transcription and translation

Molecular Cancer, 2020
RNA modifications can be added or removed by a variety of enzymes that catalyse the necessary reactions, and these modifications play roles in essential molecular mechanisms.
Hanhan Shi, Peiwei Chai, Renbing Jia, Xianqun Fan   +3 more
doaj   +1 more source

RNAME: A comprehensive database of RNA modification enzymes

Computational and Structural Biotechnology Journal, 2022
The dynamic RNA modifications were orchestrated by a series of enzymes, namely “writer”, “reader” and “eraser”, which can install, recognize and remove the modifications, respectively.
Fulei Nie, Qiang Tang, Ying Liu, Huaizhi Qin, Shilong Liu, Meng Wu, Pengmian Feng, Wei Chen   +7 more
doaj   +1 more source

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

ALKBH3 is dispensable in maintaining hematopoietic stem cells but forced ALKBH3 rectified the differentiation skewing of aged hematopoietic stem cells

Blood Science, 2020
. ALKBH3, a demethylase responsible for demethylating N1-methyladenosine (m1A) in mRNA and N1-methyldeoxyadenosine in single-stranded DNA, plays an important role in DNA repair and cancer cell proliferation.
Hanqing He, Yuqian Wang, Jianwei Wang
doaj   +1 more source