Results 71 to 80 of about 3,551 (133)

The role of RNA methylation in glioma progression: mechanisms, diagnostic implications, and therapeutic value

Frontiers in Immunology
Glioma represents a highly lethal form of malignant tumour, with RNA methylation emerging as a critical regulator of its oncogenesis and progression.
Shao-Ze Zhang, Shao-Ze Zhang, Shao-Ze Zhang, Shao-Yan Liu, Meng-Die Cheng, Yin-Feng Zhang, Jia-Wei Tian   +6 more
doaj   +1 more source

Microbial metabolites in tumor epigenetic regulation

iMeta, Volume 5, Issue 1, February 2026.
The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota‐produced SCFAs, secondary BAs, one‐carbon metabolites, and tryptophan‐derived ligands regulate histone acetylation, DNA methylation, and chromatin remodeling via HDAC, DNMT, AhR, and metabolic cofactor‐dependent pathways ...
Wangzheqi Zhang, Haoling Zhang, Yan Liao, Shuya Jiang, Haolong Zhang, Chenwei Huang, Zhijing Song, Rui Zhao, Ping Lu, Xiaohong Kang, Eryan Kong, Yalin Zhu, Wei Wang, Xuesong Liu, Yisheng Chen, Zhiwen Luo, Zhaoyu Li, Di Wang, Na Xing, Yadong Guo, Jingjing Zhang, Xiaojing Wang, Wenyi Wang, Mowaffaq Adam, Bakiah Shaharuddin, Muhamad Yusri Musa, Doblin Sandai, Chenglong Zhu, Aimin Jiang, Peng Luo, Zhijie Zhao, Zui Zou   +31 more
wiley   +1 more source

State‐of‐the‐Art Strategies for Circular RNA in Cancers: Opportunity and Challenge

MedComm, Volume 7, Issue 2, February 2026.
Overview of circular RNA in tumors. ABSTRACT Circular RNAs (circRNAs) are characterized by their covalently closed structure, remarkable stability, and precise spatiotemporal regulation, evolving from once‐overlooked transcriptional byproducts to pivotal molecular regulators.
Zehao Ding, Zai Luo, Liao Zhang, Shaopeng Zhang, Renchao Zhang, Zhengjun Qiu, Chen Huang   +6 more
wiley   +1 more source

N1-Methyladenosine (m1A) Regulator-Mediated Methylation Modification Modes and Tumor Microenvironment Infiltration Characteristics in Head and Neck Squamous Cell Carcinomas

, 2021
Background: Recent researches have investigated the biological importance of RNA N1-methyladenosine (m1A) modifications in oncogenesis and progression of head and neck squamous cell carcinoma (HNSCC). However, whether m1A modifications also have latent effect in tumor microenvironment (TME) generation and immune regulation in HNSCC is unknown. Methods:
Yan-Dong Miao, Lin-Jie Mu, Xiao-Long Tang, Jiang-Tao Wang, Jing-Jing Wu, Yong-Gang Chen, Deng-Hai Mi   +6 more
openaire   +2 more sources

Cleavage and Polyadenylation Specificity Factor Subunit 5 Regulates Pulmonary Artery Smooth Muscle Expansion and Hypoxic Response

MedComm, Volume 7, Issue 2, February 2026.
Increased miR‐3163 targets NUDT21, reducing CPSF5 levels and driving APA dysregulation. This results in 3′UTR shortening of CBFB, which stabilizes RUNX1 and promotes smooth muscle proliferation. PTGER3, is also shortened amplifying hypoxia‐induced RVSP. Together, these pathways contribute to vascular remodeling in PH. Image Created in https://BioRender.
Scott D. Collum, Lisha Zhu, Tingting W. Mills, Rene Girard, Jamie Tran, Tinne C. J. Mertens, Cory Wilson, Nancy Wareing, Erik E. Suarez, Howard J. Huang, Rahat Hussain, Bindu Akkanti, Wenjin J. Zheng, Hari K. Yalamanchili, Bela Patel, Eric J. Wagner, Sandeep Agarwal, Harry Karmouty‐Quintana   +17 more
wiley   +1 more source

RNA Modifications in Pathogenic Viruses: Existence, Mechanism, and Impacts

Microorganisms
RNA modification is a key posttranscriptional process playing various biological roles, and one which has been reported to exist extensively in cellular RNAs.
Yingying Zou, Zhoule Guo, Xing-Yi Ge, Ye Qiu   +3 more
doaj   +1 more source

Accelerate the Highly Efficient Development of mRNA Vaccines Through Advanced Computational Methods

MedComm, Volume 7, Issue 2, February 2026.
This review explores the recent advancements in applying computational methods to optimize mRNA vaccines, with a primary focus on improvements in sequence design and delivery systems. ABSTRACT mRNA medicine is an emerging therapeutic approach that utilizes messenger RNA to synthesize functional proteins directly within target cells.
Ruichu Gu, Duanmiao Si, Dingwei Lei, Xiaoxue Xie, Yongge Li, Han Wen   +5 more
wiley   +1 more source

RNA modifications and their role in gene expression

Frontiers in Molecular Biosciences
Post-transcriptional RNA modifications have recently emerged as critical regulators of gene expression programs. Understanding normal tissue development and disease susceptibility requires knowledge of the various cellular mechanisms which control gene ...
I. Made Artika, Rini Arianti, Rini Arianti, Máté Á. Demény, Endre Kristóf   +4 more
doaj   +1 more source

Adapting nanopore sequencing basecalling models for modification detection via incremental learning and anomaly detection

Nature Communications
We leverage machine learning approaches to adapt nanopore sequencing basecallers for nucleotide modification detection. We first apply the incremental learning (IL) technique to improve the basecalling of modification-rich sequences, which are usually of
Ziyuan Wang, Yinshan Fang, Ziyang Liu, Ning Hao, Hao Helen Zhang, Xiaoxiao Sun, Jianwen Que, Hongxu Ding   +7 more
doaj   +1 more source

N1-methyladenosine formation, gene regulation, biological functions, and clinical relevance

Molecular Therapy, 2023
Weidong Xiong, Yongchao Zhao, Zilun Wei, Chaofu Li, Ranzun Zhao, Junbo Ge, Bei Shi   +6 more
openaire   +1 more source