Results 81 to 90 of about 3,551 (133)

Abundant mRNA m1A modification in dinoflagellates: a new layer of gene regulation

EMBO Reports
Dinoflagellates, a class of unicellular eukaryotic phytoplankton, exhibit minimal transcriptional regulation, representing a unique model for exploring gene expression.
Chongping Li, Ying Li, Jia Guo, Yuci Wang, Xiaoyan Shi, Yangyi Zhang, Nan Liang, Honghui Ma, Jie Yuan, Jiawei Xu, Hao Chen   +10 more
doaj   +1 more source

The functions and mechanisms of RNA modification in prostate: Current status and future perspectives

Frontiers in Genetics
The increasing incidence and mortality of prostate cancer worldwide significantly impact the life span of male patients, emphasizing the urgency of understanding its pathogenic mechanism and associated molecular changes that regulate tumor progression ...
Zhijin Zhang, Zhijin Zhang, Ji Liu, Ji Liu, Yang Wu, Zhuoran Gu, Zhuoran Gu, Libin Zou, Libin Zou, Yingdi Liu, Jiang Geng, Jiang Geng, Shiyu Mao, Shiyu Mao, Ming Luo, Ming Luo, Changcheng Guo, Changcheng Guo, Wentao Zhang, Wentao Zhang, Xudong Yao, Xudong Yao   +21 more
doaj   +1 more source

Advances in research on RNA methylation and cancer radiotherapy resistance

Frontiers in Oncology
RNA methylation is a type of reversible chemical modification in epitranscriptomics that influences gene expression by dynamically regulating RNA functions.
Hui Liu, Hui Luo, Ming Jin, Zhen Zheng, Yang Xi, Kaitai Liu   +5 more
doaj   +1 more source

Involvement of N1-Methyladenosine (m1A) in the mitochondrial ND5 mRNA and the corresponding writer enzyme TRMT10C in Alzheimer's disease

, 2023
Alzheimer’s disease (AD) is a progressive neurodegenerative disease and the most common form of dementia. Even though the U.S. Food and Drug Administration (FDA) this year approved a new antibody that may moderately decelerate cognitive decline, there is still no treatment that can halt or even reverse the symptoms of AD. Apart from the prime suspects (
openaire   +3 more sources

Studies on N1-Methyladenosine Modification of rRNA in Multicellular Organisms

Studies on N1-Methyladenosine Modification of rRNA in Multicellular Organisms
2017 【要旨】
openaire   +1 more source

Emerging roles of RNA methylation modifications in environmental metalloid or metal pollutants toxicity

Ecotoxicology and Environmental Safety
The common environmental metalloid or metal pollutants such as arsenic, cadmium, chromium, lead, aluminum, cobalt and manganese have increasingly significant impacts on public health.
Rongxian Li, Yuan Zhao, Jiao Dai, Nan Zhang, Jiamin Yuan, De Liu, Zuoshun He, Jie Yang, Shiyan Gu   +8 more
doaj   +1 more source

N¹-Methyladenosine modification of mRNA regulates neuronal gene expression and oxygen glucose deprivation/reoxygenation induction. [PDF]

Cell Death Discov, 2023
Qi Z, Zhang C, Jian H, Hou M, Lou Y, Kang Y, Wang W, Lv Y, Shang S, Wang C, Li X, Feng S, Zhou H.   +12 more
europepmc   +1 more source

Unravelling the impact of RNA methylation genetic and epigenetic machinery in the treatment of cardiomyopathy

Pharmacological Research
Cardiomyopathy (CM) represents a heterogeneous group of diseases primarily affecting cardiac structure and function, with genetic and epigenetic dysregulation playing a pivotal role in its pathogenesis.
Li Liu, Linxing Yu, Yubo Wang, Liufang Zhou, Yan Liu, Xingshou Pan, Jianjun Huang   +6 more
doaj   +1 more source

RNA m1A methyltransferase TRMT61A promotes colorectal tumorigenesis by enhancing ONECUT2 mRNA stability and is a potential therapeutic target

Cancer Communications
Background The role of N1‐methyladenosine (m1A) in cancer is poorly understood. Here we explored the function of RNA methyltransferase TRNA methyltransferase 61A (TRMT61A) in colorectal cancer (CRC) and its potential as a therapeutic target.
Xiaoting Zhang, Na Qin, Fenfen Ji, Hao Su, Haiyun Shang, Hongyan Chen, Dan Huang, Qing Li, Jing Ren, Weixin Liu, Yifei Wang, Wei Kang, Jiabin Wu, Chi‐Chun Wong, Zongwei Cai, Matthew Tak Vai Chan, William Ka Kei Wu, Jun Yu, Huarong Chen   +18 more
doaj   +1 more source

N¹-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism. [PDF]

Nat Commun, 2021
Wang Y, Wang J, Li X, Xiong X, Wang J, Zhou Z, Zhu X, Gu Y, Dominissini D, He L, Tian Y, Yi C, Fan Z.   +12 more
europepmc   +1 more source