Results 131 to 140 of about 2,316 (143)

NSUN2-mediated m5C hypermethylation of <i>hsa_circ_0004516</i> promotes breast cancer brain metastasis by activating AKT signaling. [PDF]

Noncoding RNA Res
Li M, Li J, Wen H, Li J, Wang S, Guo J, Zhang D, Zhang A, Cui C, Fu R, An M, Zhang W, Fu B.   +12 more
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NSUN2 gene rs13181449 C>T polymorphism reduces neuroblastoma risk

Gene, 2023
Neuroblastoma is the most common tumor in infants. RNA m5C modification regulates the survival, differentiation, and migration of cells affecting RNA function. However, the effects of the m5C modification methyltransferase gene NSUN2 polymorphism on neuroblastoma susceptibility have not been reported.
Lei, Lin, Changmi, Deng, Chunlei, Zhou, Xinxin, Zhang, Jinhong, Zhu, Jiabin, Liu, Haiyan, Wu, Jing, He   +7 more
openaire   +2 more sources

NSUN2-Mediated m5C Methylation Impairs Endometrial Receptivity

Laboratory Investigation
Impaired endometrial decidualization is the primary cause of recurrent implantation failure (RIF). RNA methylation modification, especially NSUN family mediated m5C, is crucial for various physiological events, such as maternal-to-zygotic transition, gametogenesis, embryonic development, organismal lifespan, and cell cycle.
Jiafeng Lu, Ming Zhang, Zhenxing Liu, Ling Guo, Peng Huang, Wenjuan Xia, Jincheng Li, Jinghuan Lv, Hoi-Hung Cheung, Chenyue Ding, Hong Li, Boxian Huang   +11 more
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ETV4/NSUN2 Axis modulates aerobic glycolysis and malignancy in HSCC

Human Molecular Genetics
Abstract This study delves into the molecular intricacies of hypopharyngeal squamous cell carcinoma (HSCC), specifically focusing on the pivotal role played by ETS translocation variant 4 (ETV4) in aerobic glycolysis. The objective is to uncover new targets for early diagnosis and treatment of HSCC.
Xiaoxu Ding, Xueyan Zhang, Panxia Fang, Weiliang Bai   +3 more
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mRNA methylation by NSUN2 in cell proliferation

WIREs RNA, 2016
Methylation is a prevalent post‐transcriptional modification that occurs in almost all RNA species. NSUN2, a nucleolar RNA methyltransferase, has been shown to methylate mRNAs encoding factors that control cell division and growth arrest, thereby affecting their stability and/or translation.
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NSUN2-mediated RNA methylation: Molecular mechanisms and clinical relevance in cancer

Cellular Signalling
Cancer remains a leading cause of morbidity and mortality worldwide, necessitating the ongoing investigation of molecular targets for improved diagnosis, prognosis, and therapy. Among these targets, RNA modifications, particularly N5-methylcytosine (m5C) in RNA, have emerged as critical regulators of gene expression and cellular functions. NOP2/Sun RNA
Penghui, Li, Di, Huang
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NSun2 regulates aneurysm formation by promoting autotaxin expression and T cell recruitment

Cellular and Molecular Life Sciences, 2020
Abdominal aortic aneurysm (AAA) is characterized by inflammatory cell infiltration and aggravated by hyperhomocysteinemia (HHcy). It is unknown whether the homocysteine (Hcy)-activated RNA methyltransferase NOP2/Sun domain family member 2 (NSun2) is associated with AAA.
Yutong Miao, Yang Zhao, Lulu Han, Xiaolong Ma, Jiacheng Deng, Juan Yang, Silin Lü, Fangyu Shao, Wei Kong, Wengong Wang, Qingbo Xu, Xian Wang, Juan Feng   +12 more
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NSUN2 is critical for mouse oocyte meiosis and early embryonic development

Reproduction
In brief The mechanism by which the NSUN2 mutation causes female infertility is still unclear. This study reveals the role and potential mechanism of NSUN2 in mouse oocyte maturation and early embryonic development, and provides a resource for elucidating female infertility with NSUN2 mutations.
Tengteng Xu, Min Gao, Ling Zhang, Tianqi Cao, Yanling Qiu, Simiao Liu, Wenlian Wu, Yitong Zhou, Haiying Liu, Rui Zhang, Xiaohong Ruan, Junjiu Huang   +11 more
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LncRNA HOST2 promotes NSUN2-mediated breast cancer progression via interaction with ELAVL1

Cellular Signalling
Breast cancer (BC) is the most prevalent malignant tumor in women worldwide with high morbidity and mortality. NSUN2, a crucial RNA methyltransferase, plays a pivotal role in regulating the proliferation and metastasis of tumor cells. Our study demonstrated that NSUN2 is upregulated in BC tissues and cell lines, and its high expression is associated ...
Xuehui, Wang, Diya, Liu, Kaiyao, Hua, Lin, Fang   +3 more
openaire   +2 more sources