Results 21 to 30 of about 3,195 (172)

Co-introduction of plasmids harbouring the carbapenemase genes, bla NDM-1 and bla OXA-232, increases fitness and virulence of bacterial host [PDF]

Journal of Biomedical Science, 2020
Background Bacterial isolates with multiple plasmids harbouring different carbapenemase genes have emerged and been identified repeatedly, despite a general notion that plasmids confer fitness cost in bacterial host.
Haejeong Lee, Juyoun Shin, Yeun-Jun Chung, Myungseo Park, Kyeong Jin Kang, Jin Yang Baek, Dongwoo Shin, Doo Ryeon Chung, Kyong Ran Peck, Jae-Hoon Song, Kwan Soo Ko   +10 more
doaj   +2 more sources

Clonal dissemination of carbapenem-resistant Klebsiella pneumoniae ST16 co-producing NDM-1 and OXA-232 in Thailand. [PDF]

JAC Antimicrob Resist, 2022
Abstract Background Klebsiella pneumoniae ST258 and ST11 carrying blaKPC are among the most widespread carbapenem-resistant K. pneumoniae strains worldwide. Our carbapenem-resistant Enterobacteriaceae surveillance in Thailand revealed a nationwide dissemination of K.
Abe R, Akeda Y, Takeuchi D, Sakamoto N, Sugawara Y, Yamamoto N, Kerdsin A, Matsumoto Y, Motooka D, Leolerd W, Santanirand P, Suzuki M, Shibayama K, Tomono K, Iida T, Hamada S.   +15 more
europepmc   +3 more sources

Outbreak of Multidrug-Resistant OXA-232-Producing ST15 Klebsiella pneumoniae in a Teaching Hospital in Wenzhou, China. [PDF]

Infect Drug Resist, 2021
OXA-232-producing carbapenem-resistant Klebsiella pneumoniae (CRKP) has the potential to become the "third epidemic" of carbapenem-resistant Klebsiella strain after KPC-2 and NDM in China. We investigated the first outbreak of CRKP in the First Affiliated Hospital of Wenzhou Medical University.We collected 610 clinical isolates of CRKP from the First ...
Jia H, Zhang Y, Ye J, Xu W, Xu Y, Zeng W, Liao W, Chen T, Cao J, Wu Q, Zhou T.   +10 more
europepmc   +6 more sources

Characterization of OXA232-Producing Carbapenem-Resistant Klebsiella pneumoniae: Genomic Analysis and Virulence Assessment [PDF]

Polish Journal of Microbiology
Globally, the infection rate of carbapenem-resistant Klebsiella pneumoniae (CRKP) producing OXA-48-like carbapenemase is increasing, posing a significant public health threat due to its high antibiotic resistance.
Li Zhouxun, Wu Chunyan, Cai Xuemei, Song Yongli, Zheng Xingping, He Yuan, Song Guibo   +6 more
doaj   +2 more sources

Identification and Characterization of OXA-232-Producing Sequence Type 231 Multidrug Resistant <i>Klebsiella pneumoniae</i> Strains Causing Bloodstream Infections in China. [PDF]

Microbiol Spectr, 2023
OXA-232 carbapenemase, being a vital resistance mechanism against carbapenems, has recently been increasingly reported. In China, the identified OXA-232-producing K. pneumoniae isolates almost belonged to ST15 and were not hypervirulent, despite harboring a virulence plasmid.
Chen T, Xu H, Chen Y, Ji J, Ying C, Liu Z, Xu H, Zhou K, Xiao Y, Shen P.   +9 more
europepmc   +3 more sources

Emergence of ST15 Klebsiella pneumoniae Clinical Isolates Producing Plasmids-Mediated RmtF and OXA-232 in China

Infection and Drug Resistance, 2020
Qingyu Shi,1,2 Renru Han,1,2 Yan Guo,1,2 Yonggui Zheng,1,2 Yang Yang,1,2 Dandan Yin,1,2 Rong Zhang,3 Fupin Hu1,2 1Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China; 2Key Laboratory of Clinical ...
Shi Q, Han R, Guo Y, Zheng Y, Yang Y, Yin D, Zhang R, Hu F   +7 more
doaj   +3 more sources

Co-occurrence of OXA-232, RmtF-encoding plasmids, and pLVPK-like virulence plasmid contributed to the generation of ST15-KL112 hypervirulent multidrug-resistant Klebsiella pneumoniae. [PDF]

Front Microbiol, 2023
The emergence of carbapenem-resistant Klebsiella pneumoniae (CRKP) strains and restricted therapeutic options pose a global threat to public health. Aminoglycosides are a wise choice, which can effectively reduce the mortality rate when combined with β-lactam drugs. However, in this study, we identified a ST15-KL112 CRKP FK3006 which not only exhibited
Wu C, Zhou Y, Ai W, Guo Y, Wu X, Wang B, Zhao H, Rao L, Wang X, Zhang J, Yu F, Wang L.   +11 more
europepmc   +4 more sources

Emergence of clinical Klebsiella pneumoniae producing OXA-232 carbapenemase in Singapore. [PDF]

New Microbes New Infect, 2013
We report the emergence of OXA-232, a newly described OXA-48-like carbapenemase variant, in Southeast Asia. Molecular characterization of eight Klebsiella pneumoniae obtained from local and foreign patients reveals clonality of the isolates. bla OXA-232 was located on a non-conjugative plasmid of 6141 base pairs (GenBank accession number JX423831.1).
Teo JW, Kurup A, Lin RT, Hsien KT.
europepmc   +3 more sources

Coinfections of Two Strains of NDM-1- and OXA-232-Coproducing Klebsiella pneumoniae in a Kidney Transplant Patient. [PDF]

Antimicrob Agents Chemother, 2020
We report here a fatal case of carbapenem-resistant Klebsiella pneumoniae (CRKP) infections in a renal transplant patient without a travel history in the prior year, from whom 2 genetically different CRKP (sequence type 14 [ST14] and ST2497) strains carrying the same plasmids and antimicrobial resistance genes ...
Contreras DA, Fitzwater SP, Nanayakkara DD, Schaenman J, Aldrovandi GM, Garner OB, Yang S.   +6 more
europepmc   +7 more sources

OXA-484, an OXA-48-Type Carbapenem-Hydrolyzing Class D β-Lactamase From Escherichia coli

Frontiers in Microbiology, 2021
OXA-48-like carbapenemases are among the most frequent carbapenemases in Gram-negative Enterobacterales worldwide with the highest prevalence in the Middle East, North Africa and Europe.
Julian Sommer, Kristina M. Gerbracht, Felix F. Krause, Florian Wild, Manuela Tietgen, Manuela Tietgen, Manuela Tietgen, Sara Riedel-Christ, Janko Sattler, Axel Hamprecht, Axel Hamprecht, Volkhard A. J. Kempf, Volkhard A. J. Kempf, Stephan Göttig   +13 more
doaj   +1 more source