Results 111 to 120 of about 52,257,618 (175)

Substrate Specificity of OXA-48 after β5−β6 Loop Replacement

, 2020
OXA-48 carbapenemase has rapidly spread in many countries worldwide with several OXA-48-variants being described, differing by a few amino acid (AA) substitutions or deletions, mostly in the β5−β6 loop.
Laura Dabos (8599203), Bogdan I. Iorga (1366392), Oliver Beckstein, Agustin Zavala, Rémy A. Bonnin, Pascal Retailleau (1445848), Thierry Naas (112513), Agustin Zavala (4257250), Bogdan I. Iorga, Laura Dabos, Rémy A. Bonnin (8599206), Oliver Beckstein (1300617), Thierry Naas, Pascal Retailleau   +13 more
core   +1 more source

Activity of mecillinam against OXA-48-like carbapenemase-producing Enterobacterales

Journal of Antimicrobial Chemotherapy, 2021
Tsakris, A., Koumaki, V., Baka, S., Balakrishnan, I.   +3 more
openaire   +3 more sources

Effects of single and multiple OXA-48 mutants on enzyme activity, stability, and structure-activity relationship. Evolutionary consequences of antibiotic resistance development caused by OXA-48 [PDF]

, 2022
Antimicrobial resistance, primarily caused by the overuse of antimicrobials such as antibiotics, is becoming an increasing concern to public health.
Martinsen, Nina Nevjar
core  

Molecular, Genetic, and Biochemical Characterization of OXA-484 Carbapenemase, a Difficult-to-Detect R214G Variant of OXA-181

Microorganisms
OXA-244, an R214G variant of OXA-48, is silently spreading worldwide likely because of difficulties in detection using classical screening media. Here, we characterized two clinical isolates of Escherichia coli and Citrobacter youngae that displayed ...
Camille Gonzalez, Saoussen Oueslati, Mariam Rima, Réva Nermont, Laurent Dortet, Katie L. Hopkins, Bogdan I. Iorga, Rémy A. Bonnin, Thierry Naas   +8 more
doaj   +1 more source

OXA-48 model.

, 2015
(a) Model of population flow. (b) Within-host model in the hospital. (c) Within-host model in the community with a high risk of readmission. (d) Within-host model in the community with a low risk of readmission.
Tjaco J. M. Ossewaarde (815852), Anneke van der Zee (815853), Annet Troelstra (112779), Mirjam J. D. Dautzenberg (815851), Manon R. Haverkate (815850), Marc J. M. Bonten (109524), Jan G. den Hollander (815854), Martin C. J. Bootsma (380313)   +7 more
core   +1 more source

WGS-based characterization of trans-sectoral OXA-48-producing Escherichia coli in Switzerland

One Health Advances
The broad trans-sectoral (humans, animals, environment) dissemination potential of OXA-48 carbapenemase-producing Escherichia coli (OXA-48-Ec) and OXA-48-harboring plasmids represent a major One-Health concern.
Valentina Donà, Patrice Nordmann, Javier E. Fernandez, Laurent Poirel, Jacqueline Findlay, Simone Schuller, Sonja Kittl, Helene Rohrbach, Andrea Endimiani, Vincent Perreten   +9 more
doaj   +1 more source

In Silico to In Cerebro—Development of the Orexin Receptor Antagonist “Photorexant” for Photomodulation In Vitro and in Mouse Brains

Angewandte Chemie International Edition, Volume 65, Issue 42, 12 October 2026.
Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

Emergence of OXA-48–Like Genes in Carbapenem-Resistant Klebsiella Pneumoniae at a Tertiary Care Hospital in Pakistan

Pakistan Armed Forces Medical Journal
Objective: To determine the frequency of the Oxacillinase-48-like gene in Carbapenem-resistant Klebsiella pneumoniae isolates using conventional polymerase chain reaction (PCR). Study Design: Cross-sectional descriptive study.
Sidra Naveed, Faisal Hanif, Javiad Usman, Rafia Irfan, Warda Furqan, Amna Nasrullah   +5 more
doaj   +1 more source

Enzyme mechanism, thermostability, and structural studies of OXA-48 like carbapenemases involved in antibiotic resistance [PDF]

, 2018
Antibiotic resistance is being recognized as a world-wide crisis in modern medicine, rapidly outpacing available treatment options. The serine-beta-lactamase OXA-48 was first identified from a carbapenem- and multidrug- resistant Klebsiella pneumoniae ...
Thomassen, Ane Molden
core  

OXA-163, an OXA-48-Related Class D β-Lactamase with Extended Activity Toward Expanded-Spectrum Cephalosporins

, 2011
Two bla OXA-48 -like-positive isolates ( Klebsiella pneumoniae and Enterobacter cloacae ) were recovered in Argentina in 2008 as part of a large-scale survey focused on ...
Mariana Castanheira, Laurent Poirel, Amélie Carrër, Carla Parada Rodriguez, Jorgelina Smayevsky, Patrice Nordmann, Ronald N. Jones   +6 more
core   +1 more source