Structural basis for different substrate profiles of two closely related class D β-lactamases and their inhibition by halogens [PDF]
, 2015 OXA-163 and OXA-48 are closely related class D β-lactamases that exhibit different substrate profiles. OXA-163 hydrolyzes oxyimino-cephalosporins, particularly ceftazidime, while OXA-48 prefers carbapenem substrates.
Chow, Dar-Chone +8 more
core +1 more source
Culture-independent methods reveal high diversity of OXA-48-like genes in water environments [PDF]
Journal of Water and Health, 2017 The carbapenemase OXA-48 was identified for the first time in 2001 and is now one of the greatest concerns in terms of antibiotic resistance. While many studies report clinical OXA-48-like producers, few reports refer blaOXA-48-like genes in environmental bacteria.
Marta, Tacão +2 more
openaire +2 more sources
Blood stream infections due to OXA-48-like carbapenemase-producing Enterobacteriaceae: treatment and survival [PDF]
International Journal of Infectious Diseases, 2014 Blood stream infections (BSIs) due to carbapenem-resistant Enterobacteriaceae (CRE) are associated with high hospital mortality rates and present a tremendous challenge to clinicians. The optimal treatment remains undefined. We aimed to investigate the risk factors for mortality and the correlation between different treatment modalities and outcomes ...
Ilker Inanç Balkan +14 more
openaire +3 more sources
Detection of OXA-181 Carbapenemase in Shigella flexneri
Emerging Infectious DiseasesWe report the detection of OXA-181 carbapenemase in an azithromycin-resistant Shigella spp. bacteria in an immunocompromised patient. The emergence of OXA-181 in Shigella spp.
Ghulam Dhabaan +7 more
doaj +1 more source
In vitro activity of cefepime/zidebactam (WCK 5222) against Gram-negative bacteria [PDF]
, 2017 Background: Diazabicyclooctanes (DBOs) inhibit class A, class C and some class D β-lactamases. A few also bind PBP2, conferring direct antibacterial activity and a β-lactamase-independent ‘enhancer' effect, potentiating β-lactams targeting PBP3.
Livermore, David M +4 more
core +1 more source
Dissemination of ST101 blaOXA-48 producing Klebsiella pneumoniae at tertiary care setting
Journal of Infection in Developing Countries, 2018 Introduction: The worldwide dissemination of the acquired carbapenemases in Gram-negative bacteria is a strongly expressed demand for the emergence of post antibiotic era.
Hadir ElMahallawy +7 more
doaj +1 more source
Activity of ceftazidime/avibactam against problem Enterobacteriaceae and Pseudomonas aeruginosa in the UK, 2015-2016 [PDF]
, 2017 Background: Ceftazidime/avibactam combines an established oxyimino-cephalosporin with the first diazabicyclooctane β-lactamase inhibitor to enter clinical use.
Doumith, Michel +7 more
core +1 more source
Heterogeneous hydrolytic features for OXA-48-like β-lactamases [PDF]
, 2017 Objectives Carbapenem-hydrolysing class D β-lactamases of the OXA-48 type are increasingly reported from Enterobacteriaceae. β-Lactamase OXA-48 hydrolyses penicillins very efficiently, but carbapenems only weakly and spares broad-spectrum cephalosporins.
Nordmann, Patrice +2 more
core
Advanced Science, EarlyView.TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang +17 more
wiley +1 more source
ML Workflows for Screening Degradation‐Relevant Properties of Forever Chemicals
Advanced Science, EarlyView.The environmental persistence of per‐ and polyfluoroalkyl substances (PFAS) necessitates efficient remediation strategies. This study presents physics‐informed machine learning workflows that accurately predict critical degradation properties, including bond dissociation energies and polarizability.
Pranoy Ray +3 more
wiley +1 more source