Results 81 to 90 of about 52,257,618 (175)

Evaluation of the SpeeDx Carba (beta) multiplex real-time PCR assay for detection of NDM, KPC, OXA-48-like, IMP-4-like and VIM carbapenemase genes [PDF]

, 2019
Carbapenemase-producing organisms (CPOs) have emerged as antibiotic-resistant bacteria of global concern. Here we assessed the performance of the Carba (beta) assay, a multiplex real-time PCR assay developed by SpeeDx for the detection of key ...
Paterson, David L, Bordin, Amanda, Whiley, David M., Wee, Rachel, Zowawi, Hosam M., Zowawi, Hosam M, Harris, Patrick NA, Buckley, Cameron, Bergh, Haakon, Sidjabat, Hanna E, Whiley, David M, Tan, Lit Yeen, Windsor, Madeline, Paterson, David L., Nimmo, Graeme R, Cottrell, Kyra, Harris, Patrick N. A., Nimmo, Graeme R., Trembizki, Ella, Syrmis, Melanie   +19 more
core   +1 more source

AI‐Driven Rational Design of Nanotherapeutics for Pancreatic Ductal Adenocarcinoma

Medicinal Research Reviews, EarlyView.
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains a formidable malignancy characterized by late diagnosis, high recurrence rates, and pronounced chemoresistance. While nanoparticle‐based drug delivery systems (NDDS) offer theoretical advantages over conventional therapies, their clinical translation in PDAC has been severely limited.
Seohyun Choo, Kaeun Chae, Jueun Lee, Inseon Kim, Seunghun S. Lee   +4 more
wiley   +1 more source

Diverse reactivity of maleimides in polymer science and beyond

Polymer International, Volume 74, Issue 4, Page 296-306, April 2025.
This mini‐review provides a thorough overview of maleimide chemistry, highlighting its diverse reactivity in polymer and materials science applications. Abstract Maleimides are remarkably versatile functional groups, capable of participating in homo‐ and copolymerizations, Diels–Alder and (photo)cycloadditions, Michael additions, and other reactions ...
Bruce E Kirkpatrick, Kristi S Anseth, Tayler S Hebner   +2 more
wiley   +1 more source

Time-dependent distribution of acquired oxacillinase genes; OXA-23-like, OXA-24-like and OXA-58.

, 2014
Time-dependent distribution of acquired oxacillinase genes; OXA-23-like, OXA-24-like and OXA-58.
Suvi Koskela (511343), Sointu Mero (511344), Päivi Tissari (338900), Martti Vaara (83883), Tanja Pasanen (511342), Eveliina Tarkka (511345), Juha Kirveskari (338899)   +6 more
core   +1 more source

Assessment of Phenotypic Tools for Detection of OXA-48, KPC, and NDM in Klebsiella pneumoniae in Oman

Diagnostics
Background: The alarming increase in carbapenemase-producing Enterobacterales is a matter of grave public health concern. The most ubiquitous carbapenemases, Klebsiella pneumoniae carbapenemase (KPC)-, New Delhi metallo-β-lactamase (NDM)-, and ...
Arwa AL Rujaibi, Zaaima AL Jabri, Amina Al Jardani, Azza AL Rashdi, Azza AL Mamari, Sara AL Sumri, Hiba Sami, Zakariya Al Muharrmi, Meher Rizvi   +8 more
doaj   +1 more source

Schisandrin C Targets PPARγ to Induce Ferroptosis in Colorectal Cancer Cells and Promote M1 Macrophage Polarization

Phytotherapy Research, EarlyView.
Schisandrin C: A Dual Anti‐Colorectal Cancer Strategy Targeting PPARγ. ABSTRACT Colorectal cancer (CRC) remains a leading cause of cancer mortality, necessitating novel therapeutic strategies. Schisandrin C (SinC), a bioactive lignan from Schisandra chinensis, exhibits diverse pharmacological activities, but its anti‐CRC mechanisms are poorly ...
Xiao Wei, Hong‐Ping Wen, Jian‐Bo Song, Jin‐Fang Xu, Hong‐Rui Guo   +4 more
wiley   +1 more source

In Situ Construction of Phosphorus‐Containing Crosslinked Urethane Network Combined With Ammonium Polyphosphate via Reactive Blending for Enhancing Flame Retardancy and Anti‐Dripping Performance of Polylactic Acid Composites

Safety Science and Technology, EarlyView.
By in situ reaction blending, DOPO‐HQ and THEIC were added to PLA with MDI to construct a phosphorus containing polyurethane network, which significantly improved the flame retardant and anti‐dripping properties of polylactic acid composites. ABSTRACT Polylactic acid (PLA) is highly flammable and prone to severe melt dripping during combustion, which ...
Chiyuan Chen, Sadiqa Khan, Hongyu Yang, Xiaming Feng, Chaojun Wan   +4 more
wiley   +1 more source

The in vitro activity of aztreonam-avibactam and cefiderocol against globally collected clinical metallo-β-lactamase- and/or serine-carbapenemase-positive Enterobacterales isolates and the utility of commonly used in vitro diagnostic kits

Microbiology Spectrum
The NG-test CARBA 5 and Xpert Carba-R IVD kits were tested against 269 clinical Enterobacterales isolates selected for their previously determined carbapenemase content from the ATLAS Global Surveillance program, primarily from 2020 to 2022 ...
Mark Estabrook, Christina Streit, Andrew Townsend, Gregory Stone, Shweta Kamat, Daniel Sahm   +5 more
doaj   +1 more source

Engineering Phosphorus–Iron Coordination Complexes for Simultaneously Fire‐Retardant and Enhanced Epoxy Resins

Safety Science and Technology, EarlyView.
This flame‐retardant epoxy composite realizes synergistic fire suppression via gas‐phase and condensed‐phase dual mechanisms. In the gas phase, phosphorus‐containing radicals trap active H· and OH· radicals to interrupt flame combustion chain reactions. In the condensed phase, Fe species act as Lewis acid co‐catalysts to promote char formation, and the
Sicheng He, Lingfang Chen, Rui Chen, Kunxiong Wu, Yuanqing Chen, Jia Li, Junjie Wang, Xihuo You   +7 more
wiley   +1 more source

Oxaziridines: Versatile Reagents in Modern Organic Synthesis

The Chemical Record, EarlyView.
Being capable of transferring an O atom and N‐group/atom, oxaziridines are considered multitasking agents. These are employed for diverse organic transformations, such as epoxidation of olefins, α‐ and γ‐hydroxylation/amination of carbonyl compounds, oxidation of sulfides, [3+2]cycloaddition with unsaturated systems.
Ajeet Chandra, Subba Rao Cheekatla, Keshaba Nanda Parida   +2 more
wiley   +1 more source