Ceria–Zirconia-Supported Pt as an Efficient Catalyst for the Sustainable Synthesis of Hydroxylamines and Primary Amines via the Hydrogenation of Oximes Under Ambient Conditions [PDF]
MoleculesAmines and hydroxylamines are essential compounds in the synthesis of pharmaceuticals and other functionalized molecules. However, the synthesis of primary amines and particularly hydroxylamines remains a challenging task.
Elena Redina +5 more
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New Heterostilbene and Triazole Oximes as Potential CNS-Active and Cholinesterase-Targeted Therapeutics [PDF]
BiomoleculesNew furan, thiophene, and triazole oximes were synthesized through several-step reaction paths to investigate their potential for the development of central nervous systems (CNS)-active and cholinesterase-targeted therapeutics in organophosphorus ...
Milena Mlakić +4 more
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The Structural Diversity and Biological Activity of Steroid Oximes
Molecules, 2023 Steroids and their derivatives have been the subject of extensive research among investigators due to their wide range of pharmacological properties, in which steroidal oximes are included.
Ana R. Gomes +3 more
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Cytotoxicity-related effects of imidazolium and chlorinated bispyridinium oximes in SH-SY5Y cells
Arhiv za Higijenu Rada i Toksikologiju, 2022 Current research has shown that several imidazolium and chlorinated bispyridinium oximes are cytotoxic and activate different mechanisms or types of cell death.
Zandona Antonio +4 more
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New Uncharged 2-Thienostilbene Oximes as Reactivators of Organophosphate-Inhibited Cholinesterases
Pharmaceuticals, 2021 The inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) by organophosphates (OPs) as nerve agents and pesticides compromises normal cholinergic nerve signal transduction in the peripheral and central nervous systems (CNS) leading ...
Milena Mlakić +8 more
doaj +1 more source
Molecules, 2020 Background: Oximes are used in addition to atropine to treat organophosphate poisoning. However, the efficiency of oximes is still a matter of debate. In vitro experiments suggested than new oximes are more potent than the commercial oximes. However, the
Maya Kayouka +4 more
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Oximes: Novel Therapeutics with Anticancer and Anti-Inflammatory Potential
Biomolecules, 2021 Oximes have been studied for decades because of their significant roles as acetylcholinesterase reactivators. Over the last twenty years, a large number of oximes have been reported with useful pharmaceutical properties, including compounds with ...
Igor A. Schepetkin +4 more
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Recent Advances in N-O Bond Cleavage of Oximes and Hydroxylamines to Construct N-Heterocycle
Molecules, 2023 Oximes and hydroxylamines are a very important class of skeletons that not only widely exist in natural products and drug molecules, but also a class of synthon, which have been widely used in industrial production.
Hui-Min Jiang +4 more
doaj +1 more source
Acta Medica, 2016 Aim: The ability of two newly developed oximes (K727, K733) to reduce tabun-induced acute neurotoxic signs and symptoms was evaluated and compared with currently available trimedoxime in rats.
Jiří Kassa +2 more
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1,4-diacetoxy-β-lactams. Reactions with nucleophiles [PDF]
, 1985 β-Lactam reacts with hetero nucleophiles under ring cleavage to give 2,2-dimethyl-3-oximinobutanoic esters 6 and 7 .
Elburg, P.A. van +3 more
core +3 more sources