Results 101 to 110 of about 96,685 (285)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

The Impact of Career Adaptability on Career Plateau: The Mediating Role of Person-Job Fit and Person-Organization Fit [PDF]

open access: yesفرایند مدیریت و توسعه, 2019
This research has been conducted to examine the impact of career adaptability on career plateau by explaining the mediating role of person-job fit and person-organization fit. In terms of purpose, the study is applied and it was conducted by descriptive /
Hojjat Taheri Goodarzi, Neda Norouzi
doaj  

Images of person-organization fit: elements affecting employee organizational behavior

open access: yesKelaniya Journal of Management, 2017
The purpose of the paper is to build upon the existing literature a new approach to personorganization fit, in particular, employees’ perception of the P-O fit, taking into consideration two main criteria: 1) the level of formalization as a company’s ...
Ilona Swiatek Barylska
doaj   +1 more source

Analysis of Person-organization Fit and Person-organization Misfit in Ernst & Young Indonesia [PDF]

open access: yes, 2013
Person-Organization Fit, commonly described as the resemblance of person's values and organization values, is one of the crucial factors in determining the success of an organization.
Wowor, K. (Kristin)
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

The Influence of Person Job Fit and Person Organization Fit on Organizational Commitment

open access: yesFormosa Journal of Applied Sciences
This research aims to analyze the influence of person job fit and person organization fit on organizational commitment (study of employees of PT. Bina Media Perintis Medan). The influence between person job fit and person organization fit will be analyzed partially and simultaneously on organizational commitment.
Cindy Eunike Harefa   +1 more
openaire   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Person-organization fit (P-O fit) and engagement

open access: yesRevista Ibero-Americana de Estratégia, 2020
Objetivo do estudo: O objetivo deste trabalho é analisar o alinhamento pessoa-organização (Person-Organization fit ou P-O fit) e sua influência no engajamento de colaboradores.Metodologia/abordagem: Foi realizada uma pesquisa descritiva, analítica e hipotética-dedutiva através de um estudo de caso em uma empresa multinacional do segmento industrial.
Rodriguez, Carina Vasconcellos de Oliveira   +2 more
openaire   +1 more source

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