Results 81 to 90 of about 4,671,311 (277)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
The Relationship Between Person-Job Fit, Person-Organization Fit, Personality and Job Performance [PDF]
, 2012 This study examines factors that influence job performance among banking employees. The study was a cross sectional study where respondents’ perception was measured at one point in time. 195 respondents participated in this study.
Juliza Hartini, Johari
core +1 more source
The Role of Personality in Person-Organization Fit: An Examination of Fit Styles
, 2016 Person-organization fit has often been examined as a predictor of important workplace outcomes, but research examining the antecedents of PO fit is lacking. To date there is little information on how fit perceptions form, or if individuals react similarly to different types of fit.
openaire +2 more sources
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Person-environment fit: work-related attitudes and behavioral outcomes in continuing care retirement communities [PDF]
Doctor of PhilosophyDepartment of Hospitality Management & DieteticsChihyung OkAcademics and practitioners alike have studied the concept of person-environment fit (P-E fit) during the last two decades.
Yen, Wen-Shen
core
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Uncertainty Management’s Impact on Job Satisfaction and Innovation [PDF]
Purpose – The purpose of this paper is to examine the relationships between person-organization uncertainty management (UM) fit, and two outcomes in an innovative workplace: job satisfaction and innovation.
Mihai BOCARNEA, Michael LANE
core
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source