Results 61 to 70 of about 96,685 (285)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

PERSON-ORGANIZATION FIT DALAM RANTAI DISTRIBUSI PEMASARAN

open access: yes, 2019
Employee turnover in the poultry distribution company in Jakarta indicates low person-organization fit, organizational commitment and high turnover intention.
Ramli, Abdul Haeba
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Relationship between Perceived Fit of Nurses and Organizational Citizenship Behavior in Shiraz Hospitals

open access: yesJournal of Research Development in Nursing and Midwifery, 2014
Background and Objective: This study aimed to investigate the relationship between perceived fit of nurses and organizational citizenship behavior. Material and Methods: The statistical population of this correlational study was all nurses of Shiraz ...
Abdozahra Naami   +3 more
doaj  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

The Effect of Servant Leadership on Work Engagement: The Mediating Role of Person-Organization Fit

open access: yesMehmet Akif Ersoy Üniversitesi İktisadi ve İdari Bilimler Fakültesi Dergisi
This study aimed to explore the relationship between servant leadership and work engagement and investigate the mediating role of person-organization fit in this relationship.
Gökhan Kenek
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Mediasi Job Satisfaction pada Pengaruh Person-Job Fit, Person-Organization Fit, terhadap Organizational Citizenship Behavior di PDAM Kulon Progo

open access: yesJurnal Maksipreneur: Manajemen, Koperasi, dan Entrepreneurship
This study aims to analyze the mediating role of job satisfaction on the effect of person-job fit and person-organization fit on the organizational citizenship behavior of PDAM Tirta Binangun Kulon Progo employees.
Ahmad Hanif Mubarkah   +2 more
doaj   +1 more source

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