Results 41 to 50 of about 6,532,398 (348)

Protein translocation by the SecA ATPase occurs by a power‐stroke mechanism

EMBO Journal, 2019
SecA belongs to the large class of ATPases that use the energy of ATP hydrolysis to perform mechanical work resulting in protein translocation across membranes, protein degradation, and unfolding.
Marco A Catipovic, Benedikt W. Bauer, J. Loparo, T. Rapoport   +3 more
semanticscholar   +1 more source

Protein translocation across membranes

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2001
Cellular membranes act as semipermeable barriers to ions and macromolecules. Specialized mechanisms of transport of proteins across membranes have been developed during evolution. There are common mechanistic themes among protein translocation systems in bacteria and in eukaryotic cells.
Agarraberes, Fernando A, Dice, J.Fred
openaire   +2 more sources

Translocator Protein (TSPO) [PDF]

, 2018
The high number of papers submitted and ultimately accepted for publication in this special issue attests the great amount of research being conducted on TSPO and its role in living cells. Thus, TSPO has become an extremely attractive subcellular biomark for the early detection of disease states overexpressing this protein and for the selective ...
Nunzio Denora (Ed.), Giovanni Natile (Ed.)   +1 more
openaire   +3 more sources

Two-way communication between SecY and SecA suggests a Brownian ratchet mechanism for protein translocation

eLife, 2016
The essential process of protein secretion is achieved by the ubiquitous Sec machinery. In prokaryotes, the drive for translocation comes from ATP hydrolysis by the cytosolic motor-protein SecA, in concert with the proton motive force (PMF). However, the
William John Allen, Robin Adam Corey, Peter Oatley, Richard Barry Sessions, Steve A Baldwin, Sheena E Radford, Roman Tuma, Ian Collinson   +7 more
doaj   +1 more source

Protein Translocation into Mitochondria

Neurosignals, 2001
The biogenesis of mitochondria requires the translocation of most mitochondrial proteins across two biological membranes. Mitochondrial preproteins are synthesized in the cytosol carrying targeting information, that is recognized by specific receptor proteins.
Schmidt, Sigune, Strub, Andreas, Voos, Wolfgang   +2 more
openaire   +3 more sources

Mitochondrial precursor proteins are imported through a hydrophilic membrane environment [PDF]

, 1987
We have analyzed how translocation intermediates of imported mitochondrial precursor proteins, which span contact sites, interact with the mitochondrial membranes.
Anderson D., Argan C., Bohni P. C., Daum G., Evans E. A., Gasser S. M., Gilmore R., Guiard B., Hartl F.-U., Hennig B., Hennig B., Hortsch M., Hortsch M., Kaput J., Laemmli U. K., McAda P. C., Miura S., Nicholls D. G., Pelham H. R. B., Pfaller R., Pfaller R., Pfanner N., Pfanner N., Pfanner N., Pfanner N., Pfanner N., Pratje E., Riezman H., Sadler I., Schleyer M., Schleyer M., Schmidt B., Schwaiger M., Steck T. L., Stueber D., Wikstrom M., Zwizinski C., Zwizinski C., Zwizinski C.   +38 more
core   +1 more source

Membrane translocation of folded proteins

Journal of Biological Chemistry, 2022
An ever-increasing number of proteins have been shown to translocate across various membranes of bacterial as well as eukaryotic cells in their folded states as a part of physiological and/or pathophysiological processes. Herein, we provide an overview of the systems/processes that are established or likely to involve the membrane translocation of ...
Pei, Dehua, Dalbey, Ross E.
openaire   +2 more sources

Hsp70 at the membrane: driving protein translocation

BMC Biology, 2018
Efficient movement of proteins across membranes is required for cell health. The translocation process is particularly challenging when the channel in the membrane through which proteins must pass is narrow—such as those in the membranes of the ...
E. Craig
semanticscholar   +1 more source

Channel-Forming Bacterial Toxins in Biosensing and Macromolecule Delivery

Toxins, 2014
To intoxicate cells, pore-forming bacterial toxins are evolved to allow for the transmembrane traffic of different substrates, ranging from small inorganic ions to cell-specific polypeptides. Recent developments in single-channel electrical recordings,
Philip A. Gurnev, Ekaterina M. Nestorovich   +1 more
doaj   +1 more source

Structure of the post-translational protein translocation machinery of the ER membrane

Nature, 2018
Many proteins must translocate through the protein-conducting Sec61 channel in the eukaryotic endoplasmic reticulum membrane or the SecY channel in the prokaryotic plasma membrane1,2. Proteins with highly hydrophobic signal sequences are first recognized
Xudong Wu, C. Cabanos, T. Rapoport
semanticscholar   +1 more source