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A Dynamical Systems Perspective on Chimeric Antigen Receptor T-Cell Dosing [PDF]

, 2018
Chimeric antigen receptor T cells (CAR T cells) are dosed similarly to donor lymphocyte infusions following hematopoietic cell transplantation. In this perspective paper a mathematical basis for personalized dosing of CAR T cells is introduced.
arxiv   +1 more source

Quantifying selection in immune receptor repertoires [PDF]

Proc Natl Acad Sci USA 111(27) 9875-9880 (2014), 2014
The efficient recognition of pathogens by the adaptive immune system relies on the diversity of receptors displayed at the surface of immune cells. T-cell receptor diversity results from an initial random DNA editing process, called VDJ recombination, followed by functional selection of cells according to the interaction of their surface receptors with
arxiv   +1 more source

Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination

Proceedings of the National Academy of Sciences of the United States of America, 2016
Significance T-cell activation requires the translation of antigen binding to the T-cell receptor (TCR) into intracellular signaling. However, how antigen recognition and signal transduction are mechanistically linked is poorly understood.
Sophie V. Pageon, T. Tabarin, Yui Yamamoto, Yuanqing Ma, P. Nicovich, J. Bridgeman, A. Cohnen, Carola Benzing, Yijun Gao, M. Crowther, K. Tungatt, G. Dolton, Andrew K. Sewell, David A. Price, O. Acuto, Robert G. Parton, J. Gooding, Jérémie Rossy, J. Rossjohn, K. Gaus   +19 more
semanticscholar   +1 more source

Broad cross-reactivity of the T-cell repertoire achieves specific and sufficiently rapid target searching [PDF]

, 2017
The molecular recognition of T-cell receptors is the hallmark of the adaptive immunity. Given the finiteness of the T-cell repertoire, individual T-cell receptors are necessary to be cross-reactive to multiple antigenic peptides. In this study, we quantify the variability of the cross-reactivity by using a string model that estimates the binding ...
arxiv   +1 more source

DNA-based nanoparticle tension sensors reveal that T-cell receptors transmit defined pN forces to their antigens for enhanced fidelity

Proceedings of the National Academy of Sciences of the United States of America, 2016
Significance T cells protect the body against pathogens and cancer by recognizing specific foreign peptides on the cell surface. Because antigen recognition occurs at the junction between a migrating T cell and an antigen-presenting cell (APC), it is ...
Yang Liu, L. Blanchfield, V. P. Ma, Rakieb Andargachew, K. Galior, Zheng Liu, B. Evavold, K. Salaita   +7 more
semanticscholar   +1 more source

MediMer: a versatile do-it-yourself peptide-receptive MHC class I multimer platform for tumor neoantigen-specific T cell detection

Frontiers in Immunology
Peptide-loaded MHC class I (pMHC-I) multimers have revolutionized our capabilities to monitor disease-associated T cell responses with high sensitivity and specificity.
Marten Meyer, Marten Meyer, Marten Meyer, Christina Parpoulas, Titouan Barthélémy, Jonas P. Becker, Jonas P. Becker, Pornpimol Charoentong, Pornpimol Charoentong, Pornpimol Charoentong, Yanhong Lyu, Selina Börsig, Selina Börsig, Nadja Bulbuc, Claudia Tessmer, Claudia Tessmer, Lisa Weinacht, David Ibberson, Patrick Schmidt, Patrick Schmidt, Rüdiger Pipkorn, Stefan B. Eichmüller, Peter Steinberger, Katharina Lindner, Katharina Lindner, Isabel Poschke, Isabel Poschke, Michael Platten, Michael Platten, Michael Platten, Michael Platten, Michael Platten, Michael Platten, Stefan Fröhling, Stefan Fröhling, Stefan Fröhling, Angelika B. Riemer, Angelika B. Riemer, Jessica C. Hassel, Maria Paula Roberti, Maria Paula Roberti, Dirk Jäger, Dirk Jäger, Inka Zörnig, Inka Zörnig, Frank Momburg, Frank Momburg   +46 more
doaj   +1 more source

Chimeric antigen receptor T-cell therapy for solid tumors

Molecular Therapy: Oncolytics, 2016
Chimeric antigen receptor (CAR) T cells are engineered constructs composed of synthetic receptors that direct T cells to surface antigens for subsequent elimination.
Kheng Newick, E. Moon, S. Albelda
semanticscholar   +1 more source

Computational model for tumor response to adoptive cell transfer therapy [PDF]

arXiv, 2022
One of the barriers to the development of effective adoptive cell transfer therapies (ACT), specifically for genetically engineered T-cell receptors (TCRs), and chimeric antigen receptor (CAR) T-cells, is target antigen heterogeneity. It is thought that intratumor heterogeneity is one of the leading determinants of therapeutic resistance and treatment ...
arxiv  

Chimeric antigen receptor T-cell therapies for multiple myeloma.

Blood, 2017
Multiple myeloma (MM) is a nearly always incurable malignancy of plasma cells, so new approaches to treatment are needed. T-cell therapies are a promising approach for treating MM, with a mechanism of action different than those of standard MM treatments.
Lekha Mikkilineni, J. Kochenderfer
semanticscholar   +1 more source

T-Cell Gene Therapy in Cancer Immunotherapy: Why It Is No Longer Just CARs on The Road

Cells, 2020
T-cells have a natural ability to fight cancer cells in the tumour microenvironment. Due to thymic selection and tissue-driven immunomodulation, these cancer-fighting T-cells are generally low in number and exhausted.
Michael D. Crowther, Inge Marie Svane, Özcan Met   +2 more
doaj   +1 more source