Assessment of Tumor Relative Biological Effectiveness in Low-LET Proton Irradiation [PDF]
BiomedicinesBackground/Objectives: Within the range of spread-out Bragg peak (SOBP), LET (linear energy transfer) gradually increases from proton beam entrance point toward the beam exit direction.
Ying-Chun Lin, Jiamin Mo, Yuan-Hao Lee
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Mechanistic Modeling of the Relative Biological Effectiveness of Boron Neutron Capture Therapy [PDF]
Cells, 2020 Accurate dosimetry and determination of the biological effectiveness of boron neutron capture therapy (BNCT) is challenging because of the mix of different types and energies of radiation at the cellular and subcellular levels.
Seth W. Streitmatter +3 more
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First theoretical determination of relative biological effectiveness of very high energy electrons [PDF]
Scientific Reports, 2021 Very high energy electrons (VHEEs, E > 70 MeV) present promising clinical advantages over conventional beams due to their increased range, improved penumbra and relative insensitivity to tissue heterogeneities.
Rachel Delorme +4 more
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Thermal Neutron Relative Biological Effectiveness Factors for Boron Neutron Capture Therapy from In Vitro Irradiations [PDF]
Cells, 2020 The experimental determination of the relative biological effectiveness of thermal neutron factors is fundamental in Boron Neutron Capture Therapy. The present values have been obtained while using mixed beams that consist of both neutrons and photons of
María Pedrosa-Rivera +13 more
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Recommendations for reporting and evaluating proton therapy beyond dose and constant relative biological effectiveness [PDF]
Physics and Imaging in Radiation OncologyBackground and purpose: In proton therapy, a relative biological effectiveness (RBE) of 1.1 is used to convert proton dose into an equivalent photon dose.
Armin Lühr +10 more
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Evaluation of organ-specific relative biological effectiveness of proton therapy using radiation-induced pneumonitis as an endpoint [PDF]
Clinical and Translational Radiation OncologyBackground and purpose: Proton therapy has become widely used for non-small cell lung cancer (NSCLC) due to its ability to spare normal tissue. However, the commonly assumed relative biological effectiveness (RBE) of 1.1 may underestimate the therapy’s ...
Li Liao +9 more
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Calibration and evaluation of the relative biological effectiveness for carbon-ion radiotherapy in a new relative to a clinically applied treatment planning system [PDF]
Radiation Oncology, 2022 Background The study objective was to validate the relative biological effectiveness (RBE) in RayStation for carbon-ion radiotherapy (CIRT) using the Syngo treatment planning system as reference. Methods Local effect model I was established in RayStation
Weiwei Wang +5 more
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Relative Biological Effectiveness of High LET Particles on the Reproductive System and Fetal Development [PDF]
Life, 2020 During a space mission, astronauts are inevitably exposed to space radiation, mainly composed of the particles having high values of linear energy transfer (LET), such as protons, helium nuclei, and other heavier ions.
Bing Wang, Hiroshi Yasuda
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Variable Relative Biological Effectiveness of Protons in the Rat Spinal Cord: Measurements and Comparison With Model Calculations [PDF]
Advances in Radiation OncologyPurpose: To determine the relative biological effectiveness (RBE) in the rat spinal cord after 6 fractions of protons as a function of linear energy transfer (LET) and dose.
Christin Glowa, PhD +11 more
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Mixed- and multi-relative biological effectiveness model simultaneous optimization in carbon ion radiotherapy: A proof-of-concept [PDF]
Physics and Imaging in Radiation OncologyBackground and purpose: In carbon ion radiotherapy (CIRT), different relative biological effectiveness (RBE) models have been used for calculating RBE-weighted dose (DRBE).
Aaron Paul Osburg +8 more
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