Results 91 to 100 of about 298,878 (252)
Microdosimetric relative biological effectiveness of therapeutic proton beams
Biomedical Journal, 2015 When compared to photon beams, particle beams have distinct spatial distributions on the energy depositions in both the macroscopic and microscopic volumes. In a macroscopic volume, the absorbed dose distribution shows a rapid increase near the particle range, that is, Bragg peak, as particle penetrates deep inside the tissue.
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The Effect of Cell Oxygen Concentration on the Relative Biological Effectiveness of Low Energy X-rays [PDF]
مجله علمی دانشگاه علوم پزشکی کردستانBackground and Aim: Cancer treatment using ionizing radiation is an effective modality for the management and control of various cancers. The presence of oxygen inside the cell causes various damages to the DNA molecule.
Reza Shamsabadi, Hamid Reza Baghani
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Clinical and Translational Radiation OncologyBackground and purpose: Hypoxia in tumors significantly contributes to radiation resistance, often leading to poor treatment outcomes. In vitro studies demonstrated that proton irradiation not only exhibits an increased relative biological effectiveness (
Michaela Schmitt +5 more
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FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Relative Biological Effectiveness of Neutrons for Prophage Induction [PDF]
International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, 1973 S, Hussain +3 more
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Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Journal of Biomedical Physics and Engineering, 2017 Background: The assessment of RBE quantity in the treatment of cancer tumors with proton beams in treatment planning systems (TPS) is of high significance.
Hosseini M. A. +2 more
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