Results 131 to 140 of about 876,735 (231)

Quantifying DNA strand breaks from targeted alpha emitters 225Ac and 227Th via Geant4-DNA: implications for RBE and cell survival

EJNMMI Physics
Background Targeted alpha therapy (TAT) utilizing high-LET alpha particles from radionuclides like 225Ac and 227Th shows promise in cancer treatment due to their ability to induce dense, localized DNA damage.
Samaneh Zolghadri, Payman Rafiepour, Hassan Yousefnia   +2 more
doaj   +1 more source

Proton linear energy transfer and variable relative biological effectiveness for adolescent patients with Hodgkin lymphoma. [PDF]

BJR Open, 2023
Rechner LA, Maraldo MV, Smith EA, Lundgaard AY, Hjalgrim LL, MacKay RI, Aitkenhead AH, Aznar MC.   +7 more
europepmc   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Variations in linear energy transfer distributions within a European proton therapy planning comparison of paediatric posterior fossa tumours

Physics and Imaging in Radiation Oncology
Background and Purpose: Radiotherapy for paediatric posterior fossa tumours may cause complications in the brainstem and upper spinal cord due to high doses. With proton therapy (PT) this risk may increase due to higher relative biological effectiveness (
Peter Lægdsmand, Witold Matysiak, Ludvig P. Muren, Yasmin Lassen-Ramshad, John H. Maduro, Anne Vestergaard, Roberto Righetto, Erik Pettersson, Ingrid Kristensen, Pauline Dutheil, Charlotte Demoor-Goldschmidt, Frances Charlwood, Gillian Whitfield, Marta M. Feijoo, Anthony Vela, Fernand Missohou, Sabina Vennarini, Alfredo Mirandola, Ester Orlandi, Barbara Rombi, Anneleen Goedgebeur, Karen Van Beek, Agata Bannink-Gawryszuk, Fernando C. Campoo, Jacob Engellau, Laura Toussaint   +25 more
doaj   +1 more source

A systematic analysis of the particle irradiation data ensemble in the key of the microdosimetric kinetic model: Should clonogenic data be used for clinical relative biological effectiveness? [PDF]

Radiother Oncol, 2023
Suárez-García D, Cortés-Giraldo MA, Bertolet A.   +2 more
europepmc   +1 more source

WE-H-BRA-07: Mechanistic Modelling of the Relative Biological Effectiveness of Heavy Charged Particles [PDF]

, 2016
McMahon, S, McNamara, A, Paganetti, H, Prise, K, Schuemann, J   +4 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Validation of the relative biological effectiveness of active-energy scanning carbon-ion radiotherapy on a commercial treatment planning system with a microdosimetic kinetic model. [PDF]

Radiat Oncol, 2023
Wang W, Sun W, Shen H, Zhao J.
europepmc   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Relative biological effectiveness in proton beam therapy – Current knowledge and future challenges

Clinical and Translational Radiation Oncology, 2018
Armin Lühr, Cläre von Neubeck, Mechthild Krause, Esther G.C. Troost   +3 more
doaj   +1 more source