Results 41 to 50 of about 11,640 (148)

Perlman syndrome nuclease DIS3L2 controls cytoplasmic non-coding RNAs and provides surveillance pathway for maturing snRNAs [PDF]

, 2016
The exosome-independent exoribonuclease DIS3L2 is mutated in Perlman syndrome. Here, we used extensive global transcriptomic and targeted biochemical analyses to identify novel DIS3L2 substrates in human cells.
Bijata, Krystian, Dziembowski, Andrzej, Krawczyk, Paweł, Kuliński, Tomasz M., Tomecki, Rafał, Warkocki, Zbigniew, Łabno, Anna   +6 more
core   +1 more source

Disruption of pre-mRNA splicing in vivo results in reorganization of splicing factors [PDF]

, 1994
We have examined the functional significance of the organization of pre-mRNA splicing factors in a speckled distribution in the mammalian cell nucleus. Upon microinjection into living cells of oligonucleotides or antibodies that inhibit pre-mRNA splicing
Krainer, A. R., Mayeda, A., O'Keefe, R. T., Sadowski, C. L., Spector, D. L.   +4 more
core   +2 more sources

A label free chemoproteomic-based platform to disclose cannabidiol molecular mechanism of action on chronic myelogenous leukemia cancer cells

Heliyon
The discovery of the interactome of cannabidiol (CBD), a non-psychoactive cannabinoid from Cannabis sativa L., has been here performed on chronic myelogenous leukemia cancer cells, using an optimized chemo-proteomic stage, which links Drug Affinity ...
Sara Ceccacci, Lorenzo Corsi, Lucio Spinelli, Clarissa Caroli, Matilde Marani, Lisa Anceschi, Matteo Mozzicafreddo, Federica Pellati, Maria Chiara Monti   +8 more
doaj   +1 more source

A role for the Cajal-body-associated SUMO isopeptidase USPL1 in snRNA transcription mediated by RNA polymerase II [PDF]

, 2014
Cajal bodies are nuclear structures that are involved in biogenesis of snRNPs and snoRNPs, maintenance of telomeres and processing of histone mRNA. Recently, the SUMO isopeptidase USPL1 was identified as a component of Cajal bodies that is essential for ...
Andersen, Baillat, Bauer, Blencowe, Boisvert, Boulisfane, Broome, Campion, Carmo-Fonseca, Chen, Cioce, Collier, Cox, Cox, Cuello, Darzacq, Dundr, Durocher, Egloff, Fischer, Fischer, Fischer, Fischer, Frey, Gabanella, Ganot, Gao, Hamm, Handwerger, Hegele, Hu, Huang, Huang, Hutten, Jacobs, Jao, Jawdekar, Jády, Kambach, Kiss, Kiss, Klingauf, Kunkel, Lange, Lemm, Lindgren, Listerman, Liu, Machyna, Makarov, Mao, Massenet, Matera, Matera, Mattaj, Medlin, Meulmeester, Morris, Mouaikel, Novotný, O'Keefe, Ong, Ong, Patel, Pellizzoni, Plessel, Polak, Raška, Reddy, Sauterer, Schaffert, Schulz, Shav-Tal, Shevchenko, Sleeman, Sleeman, Smith, Smith, Sowa, Spector, Spector, Spector, Spector, Stanek, Stanek, Strzelecka, Taneja, Tucker, Tycowski, Van Arsdell, Wahl, Westin, Will, Yin, Zhang, Zhao   +95 more
core   +5 more sources

Multiple splicing factors are released from endogenous complexes during in vitro pre-mRNA splicing [PDF]

, 1989
Pre-mRNA splicing occurs in a macromolecular complex called the spliceosome. Efforts to isolate spliceosomes from in vitro splicing reactions have been hampered by the presence of endogenous complexes that copurify with de novo spliceosomes formed on ...
Conway, G. C., Krainer, A. R., Spector, D. L., Roberts, R. J.   +3 more
core  

Interactome analysis brings splicing into focus [PDF]

, 2015
The spliceosome is a huge molecular machine that assembles dynamically onto its pre-mRNA substrates. A new study based on interactome analysis provides clues about how splicing-regulatory proteins modulate assembly of the spliceosome to either activate ...
Burge, Christopher B., Dominguez, Daniel
core   +2 more sources

Electron microscopy of small nuclear ribonucleoprotein (snRNP) particles U2 and U5: evidence for a common structure-determining principle in the major U snRNP family.

Proceedings of the National Academy of Sciences, 1990
We have studied by electron microscopy the structures of native small nuclear ribonucleoprotein (snRNP) particles U2 and U5 from HeLa cells. The structure of native U2 snRNP is characterized by a main body 8 nm in diameter with one additional domain about 4 nm long and 6 nm wide.
B, Kastner, M, Bach, R, Lührmann
openaire   +3 more sources

The transcriptome of the invasive eel swimbladder nematode parasite Anguillicola crassus [PDF]

, 2013
BACKGROUND: Anguillicola crassus is an economically and ecologically important parasitic nematode of eels. The native range of A. crassus is in East Asia, where it infects Anguilla japonica, the Japanese eel. A. crassus was introduced into European eels,
Blaxter, Mark, Bridgett, Stephen, Heitlinger, Emanuel, Montazam, Anna, Taraschewski, Horst   +4 more
core   +2 more sources

An in vivo genetic screen for genes involved in spliced leader trans-splicing indicates a crucial role for continuous de novo spliced leader RNP assembly [PDF]

, 2017
ACKNOWLEDGEMENTS Some strains were provided by the CGC, which is funded by NIH Office of Research Infrastructure Programs (P40 OD010440). We would also like to thank Prof.
Albrecht, Allen, Barbee, Bell, Bernadette Connolly, Berndt Müller, Blumenthal, Blumenthal, Brahms, Brahms, Brenner, Bruzik, Conrad, Denker, Denker, Evans, Evans, Evans, Ferguson, Friesen, Fr⊘kjær-Jensen, George C. Pandarakalam, Godfrey, Hannon, Jonathan Pettitt, Jones, Kamath, Kamath, Kutscher, Lasda, Lasda, Li, Lucas Philippe, MacMorris, Maroney, Meister, Neale Harrison, Paushkin, Pellizzoni, Pettitt, Pettitt, Pillai, Pillai, Reuter, Rotimi Fasimoye, Ruegger, Schmittgen, Schneider, Sonnichsen, Stiernagle, Thomas, Timmons, Van Doren, Van Doren, Whitelaw   +54 more
core   +1 more source

Trimethylguanosine nucleoside inhibits cross-linking between snurportin 1 and m3G-capped U1 snRNA [PDF]

, 2015
Macromolecular nuclear import is an energy-and signal-dependent process. The best characterized type of nuclear import consists of proteins carrying the classical NLS that is mediated by the heterodimeric receptor importin α/β. Spliceosomal snRNPs U1, U2,
Aviñó, Anna, Bach-Elias, Montse, Bahia, Diana, Darzynkiewicz. Edward, Eritja Casadellà, Ramón   +4 more
core   +2 more sources