U12 intron positions are more strongly conserved between animals and plants than U2 intron positions [PDF]
, 2008 We report that the positions of minor, U12 introns are conserved in orthologous genes from human and Arabidopsis to an even greater extent than the positions of the major, U2 introns.
Malay KUMAR Basu +3 more
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A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing [PDF]
, 2015 Prp3 is an essential U4/U6 di-snRNP-associated protein whose functions and molecular mechanisms in pre-mRNA splicing are presently poorly understood. We show by structural and biochemical analyses that Prp3 contains a bipartite U4/U6 di-snRNA-binding ...
Bujnicki, Janusz M. +9 more
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In Vitro Studies of the Prp9·Prp11·Prp21 Complex Indicate a Pathway for U2 Small Nuclear Ribonucleoprotein Activation [PDF]
, 1996 Pre-mRNA splicing takes place on a large ribonucleoprotein particle, the spliceosome which contains the five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6. In Saccharomyces cerevisiae the mRNA splicing factors, Prp9, Prp11, and Prp21,
Abelson, John +2 more
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The intriguing case of motor neuron disease: ALS and SMA come closer [PDF]
, 2013 MNDs (motor neuron diseases) form a heterogeneous group of pathologies characterized by the progressive degeneration of motor neurons. More and more genetic factors associated with MND encode proteins that have a function in RNA metabolism, suggesting ...
Achsel, T +3 more
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Selective Recruitment of Nuclear Factors to Productively Replicating Herpes Simplex Virus Genomes [PDF]
, 2015 Much of the HSV-1 life cycle is carried out in the cell nucleus, including the expression, replication, repair, and packaging of viral genomes. Viral proteins, as well as cellular factors, play essential roles in these processes. Isolation of proteins on
DeLuca, NA, Dembowski, JA
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The Journal of biological chemistry, 2002 In the androgen receptor (AR), most of its transactivation activity is mediated via the activation function-1 (AF-1). By employing yeast two-hybrid assay, we isolated a cDNA sequence encoding a protein binding to AR-AF-1. This protein, named ANT-1 (AR N-terminal domain transactivating protein-1), enhanced the ligand-independent autonomous AF-1 ...
Yue, Zhao +7 more
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The Spliceosomal Protein Prp8 Stabilizes A Compact Conformation Of The U2-U6 Complex [PDF]
, 2012 The spliceosome is a large, RNA-protein complex that catalyzes pre-mRNA splicing during mRNA maturation. The RNA components (small nuclear RNA; snRNAs) of the spliceosome have been well studied and are believed to be involved in the splicing catalysis ...
Subasinghe, Subasinghe Appuhamilage Lemintha Imali
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The role of hnRNP H in the splicing response to genotoxic stress [PDF]
, 2015 Since early in evolutionary history, alternative RNA splicing has been an important method for metazoan organisms to regulate gene expression, allowing for a vastly expanded proteome without the need for significant genome expansion.
Stein, Chad
core
Isolation of small nuclear ribonucleoproteins containing U1, U2, U4, U5, and U6 RNAs.
Journal of Biological Chemistry, 1983 M, Hinterberger +2 more
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Human MFAP1 is a cryptic ortholog of the Saccharomyces cerevisiae Spp381 splicing factor [PDF]
, 2017 Alexander K. C. Ulrich, Markus C. Wahl
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