Results 41 to 50 of about 62,581 (273)

Effect of menopausal hormone therapy on proteins associated with senescence and inflammation

Physiological Reports, 2020
Background Estrogen may inhibit cell senescence that contributes to age‐related disorders. This study determined the effects of menopausal hormone treatments on circulating levels of markers of cell senescence.
Laura Faubion, Thomas A. White, Brett J. Peterson, Jennifer R. Geske, Nathan K. LeBrasseur, Marissa J. Schafer, Michelle M. Mielke, Virginia M. Miller   +7 more
doaj   +1 more source

Late Depression and Senescence-Associated Secretory Phenotype (SASP) [PDF]

Eur Psychiatry
Introduction Neurobiological mechanisms of late depression include abnormal regulation and interaction of multiple biological processes, as well as abnormalities of brain structures and organs.
Sidenkova A.
europepmc   +2 more sources

Loss of MECP2 Leads to Activation of P53 and Neuronal Senescence. [PDF]

, 2018
To determine the role for mutations of MECP2 in Rett syndrome, we generated isogenic lines of human induced pluripotent stem cells, neural progenitor cells, and neurons from patient fibroblasts with and without MECP2 expression in an attempt to ...
Allen, Denise, Chronis, Contantinos, Cinkornpumin, Jessica, Fu, Kai, Germanguz, Igal, Korsakova, Elena, Kuoy, Edward, Langerman, Justin, Lee, Peiyee, Lowry, William E, Ohashi, Minori, Park, Jenny C, Pellegrini, Matteo, Plath, Kathrin, Salas, Carlos, Tran, Stephen, Vargas, Benni S, Xiao, Xinshu   +17 more
core   +2 more sources

Primary high-grade serous ovarian cancer cells are sensitive to senescence induced by carboplatin and paclitaxel in vitro

Cellular & Molecular Biology Letters, 2021
Background Various types of normal and cancer cells undergo senescence in response to carboplatin and paclitaxel, which are considered the gold standard treatments in ovarian cancer management.
Paweł Uruski, Agnieszka Sepetowska, Corinna Konieczna, Martyna Pakuła, Michał Wyrwa, Akylbek Tussupkaliyev, Andrzej Tykarski, Justyna Mikuła-Pietrasik, Krzysztof Książek   +8 more
doaj   +1 more source

QS2: Aberrant Breast Adipose Stromal Cell Biology In Women At High Risk For Developing Breast Cancer

Plastic and Reconstructive Surgery, Global Open, 2021
Purpose: Our laboratory studies contributions of breast adipose stromal cells (bASCs) to breast cancer initiation and progression. To date, most studies of ASC biology have focused on abdominal ASCs.
Mahsa Taskindoust, BS, Tingjun Xie, MD, Valery Nelson, MS, Bryanna Stukes, MHS, Scott Hollenbeck, MD, Robin Bachelder, PhD   +5 more
doaj   +1 more source

Cells exhibiting strong p16INK4a promoter activation in vivo display features of senescence [PDF]

, 2019
The activation of cellular senescence throughout the lifespan promotes tumor suppression, whereas the persistence of senescent cells contributes to aspects of aging.
Diekman, Brian O., Gudkov, Andrei V., Hall, Brandon M., Krishnamurthy, Janakiraman, Liu, Jie-Yu, Parker, Joel S., Sessions, Garrett A., Sharpless, Norman E., Sorrentino, Jessica A., Souroullas, George P.   +9 more
core   +3 more sources

Chromatin basis of the senescence-associated secretory phenotype.

Trends in Cell Biology, 2022
Cellular senescence is a stable cell growth arrest. Senescent cells are metabolically active, as exemplified by the secretion of inflammatory cytokines, chemokines, and growth factors, which is termed senescence-associated secretory phenotype (SASP). The
Xue Hao, Chen Wang, Rugang Zhang
semanticscholar   +1 more source

TORCing to secretory senescence [PDF]

, 2015
Cellular senescence is often accompanied by the production of secreted proteins that mediate the diverse effects of senescence on the tissue microenvironment. The mammalian target of rapamycin (mTOR), a master regulator of protein synthesis, is now shown
Narita, Masashi, Tomimatsu, Kosuke
core   +1 more source

Diabetes-Induced Cellular Senescence and Senescence-Associated Secretory Phenotype Impair Cardiac Regeneration and Function Independently of Age.

Diabetes, 2022
Diabetes Mellitus (DM) affects the biology of multipotent cardiac stem/progenitor cells (CSCs) and adult myocardial regeneration. We assessed the hypothesis that senescence and senescence-associated secretory phenotype (SASP) are a main mechanism of ...
Fabiola Marino, Mariangela Scalise, N. Salerno, Luca Salerno, C. Molinaro, D. Cappetta, M. Torella, M. Greco, D. Foti, F. Sasso, P. Mastroroberto, A. De Angelis, G. Ellison‐Hughes, M. Sampaolesi, M. Rota, Francesco Rossi, K. Urbanek, B. Nadal-Ginard, D. Torella, E. Cianflone   +19 more
semanticscholar   +1 more source

Telomeres, oxidative stress and inflammatory factors: partners in cellular senescence? [PDF]

, 2014
Senescence, the state of irreversible cell-cycle arrest, plays paradoxical albeit important roles in vivo: it protects organisms against cancer but also contributes to age-related loss of tissue function.
Clara Correia-Melo, Graeme Hewitt, João F Passos   +2 more
core   +1 more source