Results 71 to 80 of about 62,581 (273)

The impact of cellular senescence and senescence‑associated secretory phenotype in cancer‑associated fibroblasts on the malignancy of pancreatic cancer

Oncology Report, 2023
Cancer-associated fibroblasts (CAFs) are implicated in the strong malignancy of pancreatic cancer (PC). Various CAF subtypes have different functions, and their heterogeneity likely influence the malignancy of PC.
Masaya Higashiguchi, Hirotomo Murakami, H. Akita, Shogo Kobayashi, Shokichi Takahama, Y. Iwagami, Daisaku Yamada, Y. Tomimaru, T. Noda, K. Gotoh, Y. Doki, Takuya Yamamoto, H. Eguchi   +12 more
semanticscholar   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Molecular Regulation of SASP in Cellular Senescence: Therapeutic Implications and Translational Challenges

Cells
Cellular senescence is a complex process that significantly contributes to the pathogenesis of various diseases, including cancer and neurodegenerative disorders.
Hubert Klepacki, Krystyna Kowalczuk, Natalia Łepkowska, Justyna Magdalena Hermanowicz   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

TP53 mutation‐related senescence is an indicator of hepatocellular carcinoma patient outcomes from multiomics profiles

Smart Medicine, 2023
TP53 mutation frequently occurs in hepatocellular carcinoma (HCC). Senescence also plays a vital role in the ongoing process of HCC. P53 is believed to regulate the advancement of senescence in HCC.
Yu‐Yan Chen, Zheng‐Yi Zhu, Tao Ma, Lu Zhang, Jing Chen, Jia‐Wei Jiang, Cui‐Hua Lu, Yi‐Tao Ding, Wen‐Xian Guan, Nan Yi, Hao‐Zhen Ren   +10 more
doaj   +1 more source

TREM1/3 deficiency impairs tissue repair after acute kidney injury and mitochondrial metabolic flexibility in tubular epithelial cells [PDF]

, 2019
Long-term sequelae of acute kidney injury (AKI) are associated with incomplete recovery of renal function and the development of chronic kidney disease (CKD), which can be mediated by aberrant innate immune activation, mitochondrial pathology, and ...
Borrelli, Cristiana, Butter, Loes M, Claessen, Nike, Colonna, Marco, Dessing, Mark C, Florquin, Sandrine, Leemans, Jaklien C, Rampanelli, Elena, Scantlebery, Angelique M.L, Soriani, Alessandra, Tammaro, Alessandra   +10 more
core   +2 more sources

Recurrent pregnancy loss is associated with a pro-senescent decidual response during the peri-implantation window [PDF]

, 2020
During the implantation window, the endometrium becomes poised to transition to a pregnant state, a process driven by differentiation of stromal cells into decidual cells (DC).
Brighton, Paul (Paul J.), Brosens, Jan J., Diniz-da-Costa, Maria, Ewington, Lauren J., Fishwick, Katherine J., Kong, Chow-Seng, Lipecki, Julia, Lucas, Emma S., Muter, Joanne, Odendaal, Joshua, Ott, Sascha, Quenby, Siobhan, Vrljicak, Pavle   +12 more
core   +1 more source

The aged extracellular matrix and the pro-fibrotic role of senescence -associated secretory phenotype (SASP).

American Journal of Physiology - Cell Physiology, 2023
Idiopathic pulmonary fibrosis (IPF) is an irreversible and fatal lung disease that is primarily found in the elderly population, and several studies have demonstrated that aging is the major risk factor for IPF.
Y. Mebratu, Sourabh Soni, Lorena Lorena Rosas, M. Rojas, J. Horowitz, R. Nho   +5 more
semanticscholar   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Unraveling the complexity of the senescence-associated secretory phenotype in adamantinomatous craniopharyngioma using multimodal machine learning analysis. [PDF]

Neuro Oncol
BACKGROUND Cellular senescence can have positive and negative effects on the body, including aiding in damage repair and facilitating tumor growth. Adamantinomatous Craniopharyngioma (ACP), the most common pediatric sellar/suprasellar brain tumor, poses ...
Prince EW, Apps JR, Jeang J, Chee K, Medlin S, Jackson EM, Dudley R, Limbrick D, Naftel R, Johnston J, Feldstein N, Prolo LM, Ginn K, Niazi T, Smith A, Kilburn L, Chern J, Leonard J, Lam S, Hersh DS, Gonzalez-Meljem JM, Amani V, Donson AM, Mitra SS, Bandopadhayay P, Martinez-Barbera JP, Hankinson TC.   +26 more
europepmc   +2 more sources