Results 101 to 110 of about 1,581 (183)
Revolutionizing Aging: The Dawn of Longevity Medicine and Lifespan Extension [PDF]
Ageing, conventionally measured as an inevitable biological process, is one of the major areas of leading-edge scientific research. Nowadays, the field of senolytics, telomere extension and other cellular rejuvenation techniques intended at tackling ...
Irfan, Asma
core +2 more sources
Senotherapeutic potential against xeroderma pigmentosum
AbstractXeroderma pigmentosum (XP) is an inherited photoaging syndrome caused by mutations in genes involved in the nucleotide excision repair (NER) pathway. XP patients exhibit hypersensitivity to ultraviolet (UV) radiation, leading to accelerated skin aging and requiring lifelong sun avoidance. Here, we demonstrate that UV-induced DNA damage triggers
Xuebing Wang +8 more
openaire +1 more source
Health equity engineering: Optimizing hope for a new generation of healthcare [PDF]
Medical researchers are increasingly prioritizing the inclusion of underserved communities in clinical studies. However, mere inclusion is not enough. People from underserved communities frequently experience chronic stress that may lead to accelerated ...
Balls-Berry, Joyce E +2 more
core +3 more sources
Senotherapeutics: emerging strategy for healthy aging and age-related disease
BMB Reports, 2019 Cellular senescence (CS) is one of hallmarks of aging and accumulation of senescent cells (SCs) with age contributes to tissue or organismal aging, as well as the pathophysiologies of diverse age-related diseases (ARDs). Genetic ablation of SCs in tissues lengthened health span and reduced the risk of age-related pathologies in a mouse model ...
Kim, Eok-Cheon, Kim, Jae-Ryong
openaire +3 more sources
PharmaceuticalsBackground: Cellular senescence is a biological process with a dual role in organismal health. While transient senescence supports tissue repair and acts as a tumor-suppressive mechanism, the chronic accumulation of senescent cells contributes to aging ...
Larissa Della Vedova +4 more
doaj +1 more source
SENOTHERAPEUTICS, AGING, AND AGE-RELATED DISEASES [PDF]
Innov AgingAbstract Increased translational clinical trials are addressing the utility of senotherapeutic agents as interventions for aging in general and for age-related diseases. Numerous pre-clinical trials have provided a good rationale for human clinical trials which are being increasingly proposed.
europepmc +2 more sources
Revolutionizing Diabetic Foot Ulcer Care: The Senotherapeutic Approach
Aging and diseaseDiabetic foot ulcers (DFUs) are a prevalent and profoundly debilitating complication that afflicts individuals with diabetes mellitus (DM). These ulcers are associated with substantial morbidity, recurrence rates, disability, and mortality, imposing substantial economic, psychological, and medical burdens. Timely detection and intervention can mitigate
Zhang, Guiqin +12 more
openaire +2 more sources
Cellular senescence in chronic obstructive pulmonary disease: Molecular mechanisms and therapeutic interventionsa. [PDF]
Chronic obstructive pulmonary disease (COPD) is the world's fourth highest reason for mortality, accounting for 3.5 million deaths in 2021, and about 5% of total global deaths.
Bashyal, S +10 more
core +1 more source
Clinical and Translational MedicineTumour cell senescence can be induced by various factors, including DNA damage, inflammatory signals, genetic toxins, ionising radiation and nutrient metabolism.
Jiaqiang Xiong +8 more
doaj +1 more source
Mitochondrial priming and response to BH3 mimetics in "one-two punch" senogenic-senolytic strategies [PDF]
A one-two punch sequential regimen of senescence-inducing agents followed by senolytic drugs has emerged as a novel therapeutic strategy in cancer. Unfortunately, cancer cells undergoing therapy-induced senescence (TIS) vary widely in their sensitivity ...
Alarcón Cor, Tomás +13 more
core +1 more source