Results 111 to 120 of about 1,581 (183)

Senescence profiling of monoclonal gammopathies reveals paracrine senescence as a crucial defense against disease progression [PDF]

Multiple myeloma (MM) is a plasma cell (PC) malignancy that is preceded by monoclonal gammopathy of undetermined significance (MGUS) and/or smoldering multiple myeloma (SMM).
Abdallah, Nadine, Andersen, Thomas Levin, Baughn, Linda B., Borges, Gabriel Alvares, Diaz-delCastillo, Marta, Drake, Matthew T., El-Masri, Bilal Mohamad, Gingery, Anne, Guilatco, Angelo J., Gundesen, Michael T., Hinge, Maja, Kirkland, James L., Kourelis, Taxiarchis, Lund, Thomas, Mustapha, Fatima A., Tchkonia, Tamar, Weivoda, Megan M., Xu, Ming   +17 more
core   +1 more source

Therapy-induced senescence through the redox lens

Redox Biology
Therapy-induced senescent tumor cells have emerged as significant drivers of tumor recurrence and disease relapse. Interestingly, reactive oxygen species (ROS) production and its associated redox signaling networks are intertwined with initiation and ...
Matius Robert, Brian K. Kennedy, Karen C. Crasta   +2 more
doaj   +1 more source

Screening for senolytic and senomorphic compounds in HDF76 fibroblasts and their effects as geroprotectors in C. elegans [PDF]

El envejecimiento es el principal factor de riesgo para muchas enfermedades, y la senescencia celular es un factor clave en este proceso y sus patologías relacionadas.
Sanguinet Rumayor, Sybila
core  

Editorial: Cellular Senescence: Causes, Consequences and Therapeutic Opportunities

Frontiers in Cell and Developmental Biology, 2022
Pooi-Fong Wong
doaj   +1 more source

Connecting epigenetics and inflammation in vascular senescence: state of the art, biomarkers and senotherapeutics

Frontiers in Genetics
Vascular diseases pose major health challenges, and understanding their underlying molecular mechanisms is essential to advance therapeutic interventions. Cellular senescence, a hallmark of aging, is a cellular state characterized by cell-cycle arrest, a
Oscar Fraile-Martinez, Oscar Fraile-Martinez, Diego De Leon-Oliva, Diego De Leon-Oliva, Diego Liviu Boaru, Diego Liviu Boaru, Patricia De Castro-Martinez, Patricia De Castro-Martinez, Cielo Garcia-Montero, Cielo Garcia-Montero, Silvestra Barrena-Blázquez, Silvestra Barrena-Blázquez, Joaquin García-García, Natalio García-Honduvilla, Natalio García-Honduvilla, Melchor Alvarez-Mon, Melchor Alvarez-Mon, Melchor Alvarez-Mon, Melchor Alvarez-Mon, Laura Lopez-Gonzalez, Laura Lopez-Gonzalez, Raul Diaz-Pedrero, Raul Diaz-Pedrero, Raul Diaz-Pedrero, Luis G. Guijarro, Luis G. Guijarro, Luis G. Guijarro, Luis G. Guijarro, Miguel A. Ortega, Miguel A. Ortega, Miguel A. Ortega, Miguel A. Ortega   +31 more
doaj   +1 more source

Senescence of skeletal stem cells and their contribution to age-related bone loss [PDF]

Human aging is linked to bone loss, resulting in bone fragility and an increased risk of fractures. This is primarily due to an age-related decline in the function of bone-forming osteoblastic cells and accelerated cellular senescence within the bone ...
Elkjær, Anna Sofie, Fernandez-Guerra, Paula, Figeac, Florence, Jeromdesella, Shakespeare, Kassem, Moustapha, Kjær, Pernille Kirkegaard, Nørgård, Mikkel Ørnfeldt, Wölfel, Eva M.   +7 more
core   +1 more source

Plant-Derived Senotherapeutics for the Prevention and Treatment of Intervertebral Disc Degeneration and Aging

Metabolites
Chronic low back pain, a major cause of disability with a great global socioeconomic impact, has been inextricably associated with intervertebral disc degeneration.
Eleni Mavrogonatou, Dimitris Kletsas
doaj   +1 more source

Do Sleeper Cells Hold the Key to Immortality? Senescent cells in cancer and aging [PDF]

, 2023
Aldridge, Kristin
core   +1 more source

Senescence and fibrosis in salivary gland aging and disease

Journal of Oral Biology and Craniofacial Research
Salivary gland hypofunction is highly prevalent in aged and diseased individuals leading to significant discomfort and morbidity. One factor that contributes to salivary gland hypofunction is cellular aging, or senescence.
Deirdre A. Nelson, Isabella Kazanjian, J. Andres Melendez, Melinda Larsen   +3 more
doaj   +1 more source

Senescent cell-derived extracellular vesicles as potential mediators of innate immunosenescence and inflammaging [PDF]

Ageing is accompanied by a decline in immune function (immunosenescence), increased inflammation (inflammaging), and more senescent cells which together contribute to age-related disease and infection susceptibility. The innate immune system is the front-
Chen, Yung-Yi, Hanley, Shaun, Hazeldine, Jon, Lord, Janet   +3 more
core   +1 more source