Results 1 to 10 of about 17,501 (228)
Downregulation of lncRNA SLC7A11-AS1 decreased the NRF2/SLC7A11 expression and inhibited the progression of colorectal cancer cells [PDF]
PeerJ, 2023 Colorectal cancer (CRC) is ranked as the second leading cause of cancer-related death worldwide. Many abnormally expressed long non-coding RNAs (lncRNAs) in CRC were identified with the development of next-generation sequencing, most functions of which ...
Tian Wang +6 more
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TRIM21 accelerates ferroptosis in intervertebral disc degeneration by promoting SLC7A11 ubiquitination and degradation [PDF]
Open Life SciencesIntervertebral disc degeneration (IVDD) is a common cause of chronic low back pain, and ferroptosis – an iron-dependent form of cell death – has been linked to oxidative stress-induced damage in nucleus pulposus cells (NPCs).
Yu Wei, Liu Yong, Zhou Feng
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Progress in research on the mechanisms and therapeutic strategies of SLC7A11 regulation in glioma [PDF]
Discover OncologyThis review summarizes the critical role of SLC7A11 in the pathogenesis of glioma and its potential as a therapeutic target. By mediating cystine uptake and glutamate release, SLC7A11 promotes glutathione (GSH) synthesis, protecting glioma cells from ...
Qianfeng Wei +4 more
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Autoimmunity, 2022 Background The hsa_circRNA_103809 (circ_0072088) has been an emerging tumour regulator in human cancers, and is identified as one most aberrantly expressed circRNA in patients with pancreatic ductal adenocarcinoma (PDAC).
Hui Sun, Fang Liu, Hongqing Zhang
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Frontiers in Bioscience-Landmark, 2023 Glial cells play an essential role in the complex function of the nervous system. In particular, astrocytes provide nutritive support for neuronal cells and are involved in regulating synaptic transmission.
Marc Dahlmanns +4 more
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Cancer Cell International, 2023 Background Disulfidptosis and the disulfidptosis-related gene SLC7A11 have recently attracted significant attention for their role in tumorigenesis and tumour management.
Tonghu Liu +9 more
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BMC Molecular and Cell Biology, 2022 Background Chaperonin containing TCP1 subunit 3 (CCT3) acts as an oncogene in cancers, whereas its role and underlying mechanisms in lung adenocarcinoma (LUAD) are poorly understood.
Kun Wang +6 more
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Pteridines, 2021 Ferroptosis is a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides, which was involved in the progression of malignant tumors including non-small cell lung cancer (NSCLC).
Huang He +4 more
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A mTORC1-mediated cyst(e)ine sensing mechanism governing GPX4 synthesis and ferroptosis
Molecular & Cellular Oncology, 2021 Ferroptosis is a cell death mechanism triggered by lipid peroxidation. Our recent study linked cyst(e)ine availability with glutathione peroxidase 4 (GPX4) protein synthesis and ferroptosis mitigation via a Rag-mechanistic target of rapamycin complex 1 ...
Yuelong Yan, Guang Lei, Boyi Gan
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Molecular & Cellular Oncology, 2017 Effective therapeutic strategies to target mutant tumor protein p53 (TP53, best known as p53) cancers remain an unmet medical need. We found that mutant p53 impairs the function of nuclear factor (erythroid-derived 2)-like 2 (NFE2L2, commonly known as ...
Nicholas J. Clemons +3 more
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