Results 11 to 20 of about 17,501 (228)
SLC7A11, a potential immunotherapeutic target in lung adenocarcinoma
Scientific Reports, 2023 SLC7A11 has significant translational value in cancer treatment. However, there are few studies on whether SLC7A11 affects the immune status of lung adenocarcinoma (LUAD).
Qingqing Shan +7 more
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The amino acid transporter SLC7A11 expression in breast cancer
Cancer Biology & Therapy, 2023 Breast cancer (BC), characterized by its diverse molecular profiles and clinical outcomes, presents a significant challenge in the development of effective therapeutic strategies.
Preyanka Nath +8 more
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High glucose induces podocyte ferroptosis through BAP1/SLC7A11 pathway
HeliyonBackground: Ferroptosis plays an important role in the development of diabetic nephropathy (DN). However, its specific regulatory mechanisms remain unclear.
Ren Peiyao +6 more
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MiR-93-5p inhibits ovarian cancer through SLC7A11-mediated-ferroptosis
HeliyonAim: Ovarian cancer (OC) is the most lethal gynecological malignancy, which seriously affects the prognosis and life quality of female patients. Therefore, new therapeutic targets and treatments are urgently needed.
Chunxia Li +4 more
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Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling
Molecular Cell, 2022 IDO1 oxidizes tryptophan (TRP) to generate kynurenine (KYN), the substrate for 1-carbon and NAD metabolism, and is implicated in pro-cancer pathophysiology and infection biology. However, the mechanistic relationships between IDO1 in amino acid depletion versus product generation have remained a longstanding mystery.
Alessandra Fiore +9 more
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Glioma, glutamate (SLC7A11) and seizures—a commentary [PDF]
Annals of Translational Medicine, 2017 Glioma, a common type of adult primary brain tumor and also the most dreaded, often presents to the clinic with seizures. These seizures are usually difficult to control with the standard anti-epileptics. Some of the patients presenting with medically refractory epilepsy due to a low grade glioma, achieve seizure control by surgical resection but some ...
Vani, Santosh, Palavalasa, Sravya
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Metformin Induces Ferroptosis byInhibiting UFMylation of SLC7A11 in Breast Cancer [PDF]
Journal of Experimental & Clinical Cancer Research, 2021 Abstract Background Ferroptosis is a newly defined form of regulated cell death characterized by the iron-dependent accumulation of lipid peroxidation and is involved in various pathophysiological conditions, including cancer. Targeting ferroptosis is considered to be a novel anti-cancer strategy.
Jingjing Yang +13 more
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The Deubiquitylase OTUB1 Mediates Ferroptosis via Stabilization of SLC7A11 [PDF]
Cancer Research, 2019 Abstract Although cell-cycle arrest, senescence, and apoptosis are established mechanisms of tumor suppression, accumulating evidence reveals that ferroptosis, an iron-dependent, nonapoptotic form of cell death, represents a new regulatory pathway in suppressing tumor development.
Tong, Liu +3 more
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Histone demethylase KDM3B protects against ferroptosis by upregulating SLC7A11 [PDF]
FEBS Open Bio, 2020 Ferroptosis is a type of adaptive cell death driven by cellular metabolism and iron‐dependent lipid peroxidation. Though multiple genes (including SLC7A11 and GPX4) have been demonstrated to play key roles in ferroptosis, little is known about the epigenetic regulation of this process.
Yishu Wang +7 more
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SLC7A11, a Potential Therapeutic Target Through Induced Ferroptosis in Colon Adenocarcinoma
Frontiers in Molecular Biosciences, 2022 Background: Ferroptosis induced by SLC7A11 has an important translational value in the treatment of cancers. However, the mechanism of SLC7A11 in the pathogenesis of colon adenocarcinoma (COAD) is rarely studied in detail.Methods: SLC7A11 expression was ...
Xin Cheng +5 more
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