Results 31 to 40 of about 17,501 (228)

High SLC7A11 expression in normal skin of melanoma patients [PDF]

Cancer Epidemiology, 2019
Melanoma is one of the highest metastatic cancers and its incidence is rapidly increasing. A great effort has been devoted to determine gene mutations and expression profiles in melanoma cells, but less attention has been given to the possible influence of melanin synthesis in melanocytes on melanomagenesis.
Galván, Ismael, Inácio, Ângela, Dañino, María, Corbí-Llopis, Rosa, Monserrat, María T., Bernabeu-Wittel, José   +5 more
openaire   +5 more sources

The SLC7A11: sperm mitochondrial function and non-canonical glutamate metabolism [PDF]

Reproduction, 2020
Spermatozoa are redox-regulated cells, and stallion spermatozoa, in particular, present an intense mitochondrial activity in which large amounts of reactive oxygen species (ROS) are produced. To maintain the redox potential under physiological conditions, sophisticated mechanisms ought to be present, particularly in the mitochondria.
Ortiz-Rodriguez J. M., Martin-Cano F. E., Gaitskell-Phillips G., Silva A., Tapia J. A., Gil M. C., Redondo E., Masot J., Ortega-Ferrusola C., Pena F. J.   +9 more
openaire   +3 more sources

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Intra-Tumoral Expression of SLC7A11 Is Associated with Immune Microenvironment, Drug Resistance, and Prognosis in Cancers: A Pan-Cancer Analysis

Frontiers in Genetics, 2021
While many anti-cancer modalities have shown potent efficacy in clinical practices, cancer prevention, timely detection, and effective treatment are still challenging.
Jiajun He, Hongjian Ding, Huaqing Li, Zhiyu Pan, Qian Chen   +4 more
doaj   +1 more source

miR-16-5p Regulates Ferroptosis by Targeting SLC7A11 in Adriamycin-Induced Ferroptosis in Cardiomyocytes

Journal of Inflammation Research, 2023
Yongquan Chen, Yecheng Deng, Linghua Chen, Ziyao Huang, Yi Yan, Zhaoqi Huang Department of Cardiology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of ChinaCorrespondence: Zhaoqi Huang, Department of ...
Chen Y, Deng Y, Chen L, Huang Z, Yan Y, Huang Z   +5 more
doaj  

Up-Regulation of circEIF6 Contributes to Pancreatic Cancer Development Through Targeting miR-557/SLC7A11/PI3K/AKT Signaling

Cancer Management and Research, 2021
Tiequan Zhang, Mi Li, Haofeng Lu, Tao Peng Department of Hepatobiliary Surgery, The First People’s Hospital of Jingzhou, Jingzhou 434000, People’s Republic of ChinaCorrespondence: Tiequan ZhangDepartment of Hepatobiliary Surgery, The First ...
Zhang T, Li M, Lu H, Peng T
doaj  

MiR-27a-3p Promotes Non-Small Cell Lung Cancer Through SLC7A11-Mediated-Ferroptosis

Frontiers in Oncology, 2021
BackgroundFerroptosis is a newly generated regulatory cell death promoted by the accumulated lipid-based reactive oxygen species (ROS). Solute carrier family 7 member 11 (SLC7A11), the cystine/glutamate antiporter, is known as a ferroptosis executor that
Xuan Lu, Ningning Kang, Xinxin Ling, Ming Pan, Wenjing Du, Shan Gao   +5 more
doaj   +1 more source

Identification of SLC7A11‐AS1/SLC7A11 pair as a ferroptosis‐related therapeutic target for hepatocellular carcinoma

Journal of Cellular and Molecular Medicine
AbstractHepatocellular carcinoma (HCC), a prevalent malignancy worldwide, poses significant challenges in terms of prognosis, necessitating innovative therapeutic approaches. Ferroptosis offers notable advantages over apoptosis, holding promise as a novel therapeutic approach for HCC complexities. Moreover, while the interaction between long non‐coding
Xiao Yuan, Yida Wang, Sitong Jiao, Huanhuan Gao, Mengqian Zhang, Xin Wang, Xunyu Zhou, Chuanfang Wu, Jinku Bao   +8 more
openaire   +2 more sources

Comparative analysis of antibodies to xCT (Slc7a11): Forewarned is forearmed

Journal of Comparative Neurology, 2015
ABSTRACTThe cystine/glutamate antiporter or system exchanges cystine for glutamate, thereby supporting intracellular glutathione synthesis and nonvesicular glutamate release. The role of system in neurological disorders can be dual and remains a matter of debate. One important reason for the contradictory findings that have been reported to date is
Van Liefferinge, Joeri, Bentea, Eduard, Demuyser, Thomas, Albertini, Giulia, Follin-Arbelet, Virginie, Holmseth, Silvia, Merckx, Ellen, Hideyo, Sato, Aerts, Joeri L, Smolders, Ilse, Arckens, Lutgarde, Danbolt, Niels C, Massie, Ann   +12 more
openaire   +3 more sources

SLC7A11 promotes EMT and metastasis in invasive pituitary neuroendocrine tumors by activating the PI3K/AKT signaling pathway

Endocrine Connections
Invasive pituitary neuroendocrine tumors (PitNETs) are the most prevalent types of intracranial and neuroendocrine tumors. Their aggressive growth and difficulty in complete resection result in a high recurrence rate.
Shikai Gui, Wanli Yu, Jiabao Xie, Lunshan Peng, Yuanyuan Xiong, Zhen Song, Haitao Luo, Juexian Xiao, Shengtao Yuan, Zujue Cheng   +9 more
doaj   +1 more source