Evolutionary conservation of intrinsically unstructured regions in slit-diaphragm proteins. [PDF]
PLoS ONE, 2021 Vertebrate kidneys contribute to homeostasis by regulating electrolyte, acid-base balance, removing toxic metabolites from blood, and preventing protein loss into the urine.
Sandeep K N Mulukala +3 more
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Selective endocytosis controls slit diaphragm maintenance and dynamics in Drosophila nephrocytes [PDF]
eLife, 2022 The kidneys generate about 180 l of primary urine per day by filtration of plasma. An essential part of the filtration barrier is the slit diaphragm, a multiprotein complex containing nephrin as major component.
Konrad Lang +12 more
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mTOR-Dependent Autophagy Regulates Slit Diaphragm Density in Podocyte-like Drosophila Nephrocytes [PDF]
Cells, 2022 Both mTOR signaling and autophagy are important modulators of podocyte homeostasis, regeneration, and aging and have been implicated in glomerular diseases.
Dominik Spitz +6 more
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Rap1 Activity Is Essential for Focal Adhesion and Slit Diaphragm Integrity [PDF]
Frontiers in Cell and Developmental Biology, 2022 Glomerular podocytes build, with their intercellular junctions, part of the kidney filter. The podocyte cell adhesion protein, nephrin, is essential for developing and maintaining slit diaphragms as functional loss in humans results in heavy proteinuria.
Mee-Ling Maywald +9 more
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A slit-diaphragm-associated protein network for dynamic control of renal filtration [PDF]
Nature Communications, 2022 The slit-diaphragm is a cellular junction that is crucial for blood filtration in the kidney. Kocylowski et al. show that the junction-spanning components are embedded in a protein network for dynamic control of filtration; network disturbance leads to ...
Maciej K. Kocylowski +21 more
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Role of Protein Kinase C (PKC) in Podocytes and Development of Glomerular Damage in Diabetic Nephropathy [PDF]
Frontiers in Endocrinology, 2014 The early glomerular changes in diabetes include a podocyte phenotype with loss of slit diaphragm proteins, changes in the actin cytoskeleton and foot process architecture.
Beina eTeng +4 more
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Oxidative Stress Contributes to Slit Diaphragm Defects Caused by Disruption of Endocytosis [PDF]
Kidney International ReportsIntroduction: Podocyte slit diaphragms are an important component of the glomerular filtration barrier. Podocyte injury frequently includes defects in slit diaphragms, and various mechanisms for these defects have been described, including altered ...
Gang Xi +3 more
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Actin Cytoskeleton and Integrin Components Are Interdependent for Slit Diaphragm Maintenance in Drosophila Nephrocytes [PDF]
CellsIn nephrotic syndrome, the podocyte filtration structures are damaged in a process called foot process effacement. This is mediated by the actin cytoskeleton; however, which actins are involved and how they interact with other filtration components, like
Megan Delaney +4 more
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Slit diaphragm maintenance requires dynamic clathrin-mediated endocytosis facilitated by AP-2, Lap, Aux and Hsc70-4 in nephrocytes [PDF]
Cell & Bioscience, 2021 Background The Slit diaphragm (SD) is the key filtration structure in human glomerular kidney that is affected in many types of renal diseases. SD proteins are known to undergo endocytosis and recycling to maintain the integrity of the filtration ...
Luyao Wang +4 more
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The slit diaphragm in Drosophila exhibits a bilayered, fishnet architecture [PDF]
Nature CommunicationsThe kidney relies on the glomerulus to filter large volumes of blood plasma, with the slit diaphragm (SD) as a key structural component of the glomerular filtration barrier.
Deborah Moser +7 more
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