Evolutionary conservation of intrinsically unstructured regions in slit-diaphragm proteins. [PDF]
PLoS One, 2021 Vertebrate kidneys contribute to homeostasis by regulating electrolyte, acid-base balance, removing toxic metabolites from blood, and preventing protein loss into the urine.
Mulukala SKN +3 more
europepmc +6 more sources
Oxidative Stress Contributes to Slit Diaphragm Defects Caused by Disruption of Endocytosis. [PDF]
Kidney Int Rep, 2023 Introduction: Podocyte slit diaphragms are an important component of the glomerular filtration barrier. Podocyte injury frequently includes defects in slit diaphragms, and various mechanisms for these defects have been described, including altered ...
Xi G, Lamba SA, Mysh M, Poulton JS.
europepmc +3 more sources
Proteinuric Kidney Diseases: A Podocyte's Slit Diaphragm and Cytoskeleton Approach. [PDF]
Front Med (Lausanne), 2018 Proteinuric kidney diseases are a group of disorders with diverse pathological mechanisms associated with significant losses of protein in the urine.
Yu SM +3 more
europepmc +6 more sources
Rap1 Activity Is Essential for Focal Adhesion and Slit Diaphragm Integrity. [PDF]
Front Cell Dev Biol, 2022 Glomerular podocytes build, with their intercellular junctions, part of the kidney filter. The podocyte cell adhesion protein, nephrin, is essential for developing and maintaining slit diaphragms as functional loss in humans results in heavy proteinuria.
Maywald ML +9 more
europepmc +3 more sources
mTOR-Dependent Autophagy Regulates Slit Diaphragm Density in Podocyte-like Drosophila Nephrocytes. [PDF]
Cells, 2022 Both mTOR signaling and autophagy are important modulators of podocyte homeostasis, regeneration, and aging and have been implicated in glomerular diseases.
Spitz D +6 more
europepmc +3 more sources
A slit-diaphragm-associated protein network for dynamic control of renal filtration. [PDF]
Nat Commun, 2022 The slit-diaphragm is a cellular junction that is crucial for blood filtration in the kidney. Kocylowski et al. show that the junction-spanning components are embedded in a protein network for dynamic control of filtration; network disturbance leads to ...
Kocylowski MK +21 more
europepmc +3 more sources
Actin Cytoskeleton and Integrin Components Are Interdependent for Slit Diaphragm Maintenance in <i>Drosophila</i> Nephrocytes. [PDF]
CellsIn nephrotic syndrome, the podocyte filtration structures are damaged in a process called foot process effacement. This is mediated by the actin cytoskeleton; however, which actins are involved and how they interact with other filtration components, like
Delaney M +4 more
europepmc +3 more sources
The slit diaphragm in Drosophila exhibits a bilayered, fishnet architecture. [PDF]
Nat CommunThe kidney relies on the glomerulus to filter large volumes of blood plasma, with the slit diaphragm (SD) as a key structural component of the glomerular filtration barrier.
Moser D +7 more
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Slit diaphragm maintenance requires dynamic clathrin-mediated endocytosis facilitated by AP-2, Lap, Aux and Hsc70-4 in nephrocytes. [PDF]
Cell Biosci, 2021 Background The Slit diaphragm (SD) is the key filtration structure in human glomerular kidney that is affected in many types of renal diseases. SD proteins are known to undergo endocytosis and recycling to maintain the integrity of the filtration ...
Wang L +4 more
europepmc +3 more sources
Organoids from Nephrotic Disease-Derived iPSCs Identify Impaired NEPHRIN Localization and Slit Diaphragm Formation in Kidney Podocytes. [PDF]
Stem Cell Reports, 2018 Summary: Mutations in the NPHS1 gene, which encodes NEPHRIN, cause congenital nephrotic syndrome, resulting from impaired slit diaphragm (SD) formation in glomerular podocytes.
Tanigawa S +13 more
europepmc +3 more sources