Results 51 to 60 of about 6,568 (206)

Key Interventions in Friedreich's Ataxia and Their Impact on Patient Outcomes: A Systematic Review

Movement Disorders, EarlyView.
Abstract Friedreich's ataxia (FA) is a rare neurodegenerative disease with multisystemic symptoms that requires multidisciplinary care. This systematic review summarizes available pharmacological and nonpharmacological interventions, their outcomes, and alignment with patient‐centered care domains, as well as their impact on these domains.
Dorota Sarwinska, Maresa Buchholz, Audrey Iskandar, Marcus Grobe‐Einsler, Thomas Klockgether, Jennifer Faber, Bernhard Michalowsky   +6 more
wiley   +1 more source

Vitamin E beyond Its Antioxidant Label

Antioxidants, 2021
Vitamin E, comprising tocopherols and tocotrienols, is mainly known as an antioxidant. The aim of this review is to summarize the molecular mechanisms and signaling pathways linked to inflammation and malignancy modulated by its vitamers.
Anca Ungurianu, Anca Zanfirescu, Georgiana Nițulescu, Denisa Margină   +3 more
doaj   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Engineering endosperm storage compartments enables simultaneous enrichment of multiple vitamins in rice

Journal of Integrative Plant Biology, EarlyView.
Engineering rice endosperm with modules for vitamin binding, lipid storage, and antioxidant protection enriched water‐ and fat‐soluble vitamins without compromising key agronomic traits and maintained vitamin higher levels after cooking, demonstrating its potential to improve crop nutrition.
Xingwei Cai, Huanteng Hou, Yuanyue Wang, Wenyao Tan, Haifeng Zhu, Mustafa Bulut, Zhuang Yang, Ran Xu, Xianqing Liu, Alisdair R. Fernie, Jie Li, Yufei Li, Jie Luo   +12 more
wiley   +1 more source

Formulation and In Vivo Evaluation of a Solid Self-Emulsifying Drug Delivery System Using Oily Liquid Tocotrienols as Model Active Substance

Pharmaceutics, 2021
Self-emulsifying drug delivery systems (SEDDS) can improve the oral bioavailability of poorly water-soluble drugs. Solid self-emulsifying drug delivery systems (s-SEDDS) offer several advantages including improved drug stability, ease of administration ...
You Zhuan Lee, Eng Kwong Seow, Sheau Chin Lim, Kah Hay Yuen, Nurzalina Abdul Karim Khan   +4 more
doaj   +1 more source

Tocotrienol as a potential anticancer agent [PDF]

Carcinogenesis, 2011
Vitamin E is composed of two structurally similar compounds: tocopherols (TPs) and tocotrienols (T3). Despite being overshadowed by TP over the past few decades, T3 is now considered to be a promising anticancer agent due to its potent effects against a wide range of cancers. A growing body of evidence suggests that in addition to its antioxidative and
Ling, Patrick, Luk, Sze Ue, Al-Ejeh, Fares, Khanna, Kum   +3 more
openaire   +6 more sources

Revisiting the therapeutic potential of tocotrienol

BioFactors, 2022
AbstractThe therapeutic potential of the tocotrienol group stems from its nutraceutical properties as a dietary supplement. It is largely considered to be safe when consumed at low doses for attenuating pathophysiology as shown by animal models, in vitro assays, and ongoing human trials.
Ranmali Ranasinghe, Michael Mathai, Anthony Zulli   +2 more
openaire   +3 more sources

Diet‐Related Differences Predominate Over Breed‐Associated Differences in Hepatic Lipid Metabolism, Antioxidant Vitamins and Lipid Quality Indices Among Beef Cattle

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Understanding how nutritional management and genetic background influence hepatic metabolism is important for improving the nutritional quality of bovine products in tropical production systems. This study evaluated breed‐associated differences under a common dietary regimen and diet‐related differences within the Nelore breed with respect to ...
Laíza de Kássia Mendes da Conceição, José de Brito Lourenço‐Júnior, Jamile Andréa Rodrigues da Silva, Leonel António Joaquim, Mariana Jucá Moraes, Thomaz Cyro Guimarães de Carvalho Rodrigues, Joana Inês Ferreira, Ana Maria Ramos Fontes, Maria Pinheiro Spínola, Érica Coutinho David, Antônio Vinicius Correa Barbosa, Bruno Cabral Soares, José António Mestre Prates   +12 more
wiley   +1 more source

Effects of late administration of pentoxifylline and tocotrienols in an image-guided rat model of localized heart irradiation.

PLoS ONE, 2013
Radiation-induced heart disease (RIHD) is a long-term side effect of radiotherapy of intrathoracic, chest wall and breast tumors when radiation fields encompass all or part of the heart.
Vijayalakshmi Sridharan, Preeti Tripathi, Sunil Sharma, Peter M Corry, Eduardo G Moros, Awantika Singh, Cesar M Compadre, Martin Hauer-Jensen, Marjan Boerma   +8 more
doaj   +1 more source

The cereal grains: focus on vitamin E

Czech Journal of Food Sciences, 2001
Tocopherols (T) and tocotrienols (T3) were analysed using HPLC and vitamin E content was calculated in selected cereal grains and their different morphological fractions. Wheat (Triticum aestivum L.) cv. Almari, barley (Hordeum vulgare L.) cv.
H. Zielinski, E. Ciska, H. Kozlowska
doaj   +1 more source