Results 11 to 20 of about 118,565,731 (151)

Go Green: The Antiinflammatory Effects of Biliverdin Reductase [PDF]

Frontiers in Pharmacology, 2012
Biliverdin (BV) has emerged as a cytoprotective and important anti-inflammatory molecule. Conversion of BV to bilirubin (BR) is catalyzed by biliverdin reductase (BVR) and is required for the downstream signaling and nuclear localization of BVR.
Barbara eWegiel, Leo eOtterbein
doaj   +5 more sources

Biliverdin Reductase-A Deficiency Brighten and Sensitize Biliverdin-binding Chromoproteins [PDF]

Cell Structure and Function, 2020
Tissue absorbance, light scattering, and autofluorescence are significantly lower in the near-infrared (NIR) range than in the visible range. Because of these advantages, NIR fluorescent proteins (FPs) are in high demand for in vivo imaging. Nevertheless, application of NIR FPs such as iRFP is still limited due to their dimness in mammalian cells.
Sumiyama, Kenta, Matsuda, Michiyuki, Terai, Kenta, Kobachi, Kenju, Kuno, Sota, Sato, Shinya   +5 more
openaire   +6 more sources

The specificity of biliverdin reductase

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1984
The specificity of rat liver biliverdin reductase was examined with the help of a series of synthethic biliverdins. The mixture of the four biliverdin isomers obtained by the chemical oxidation of protohemin I, protohemin XI, protohemin XIV and ...
Josefina Awruch, María L. Tomaro, Rosalía B. Frydman, Benjamín Frydman   +3 more
core   +3 more sources

Combined fluorometric analysis of biliverdin and bilirubin by the recombinant protein HUG [PDF]

MethodsX
Biliverdin is a secondary metabolite of heme catabolism. It is formed by the reaction catalyzed by heme oxygenase, which converts the heme group contained in proteins such as hemoglobin, myoglobin, cytochromes, and catalase into biliverdin, iron (II) and
Federica Tramer, Paola Sist, Rocio Cardenas-Perez, Ranieri Urbani, Giulia Bortolussi, Sabina Passamonti   +5 more
doaj   +2 more sources

Biliverdin reductase and bilirubin in hepatic disease [PDF]

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2018
The buildup of fat in the liver (hepatic steatosis) is the first step in a series of incidents that may drive hepatic disease. Obesity is the leading cause of nonalcoholic fatty liver disease (NAFLD), in which hepatic steatosis progresses to liver disease.
Lauren Weaver, Abdul-rizaq Hamoud, David E. Stec, Terry D. Hinds   +3 more
openaire   +3 more sources

Biliverdin Reductase-A integrates insulin signaling with mitochondrial metabolism through phosphorylation of GSK3β [PDF]

Redox Biology
Brain insulin resistance links the failure of energy metabolism with cognitive decline in both type 2 Diabetes Mellitus (T2D) and Alzheimer's disease (AD), although the molecular changes preceding overt brain insulin resistance remain unexplored ...
Chiara Lanzillotta, Antonella Tramutola, Simona Lanzillotta, Viviana Greco, Sara Pagnotta, Caterina Sanchini, Silvia Di Angelantonio, Elena Forte, Serena Rinaldo, Alessio Paone, Francesca Cutruzzolà, Flavia Agata Cimini, Ilaria Barchetta, Maria Gisella Cavallo, Andrea Urbani, D. Allan Butterfield, Fabio Di Domenico, Bindu D. Paul, Marzia Perluigi, Joao M.N. Duarte, Eugenio Barone   +20 more
doaj   +3 more sources

Biliverdin Reductase A (BVRA) Knockout in Adipocytes Induces Hypertrophy and Reduces Mitochondria in White Fat of Obese Mice

Biomolecules, 2020
Biliverdin reductase (BVR) is an enzymatic and signaling protein that has multifaceted roles in physiological systems. Despite the wealth of knowledge about BVR, no data exist regarding its actions in adipocytes.
David E. Stec, Darren M. Gordon, Andrea L. Nestor-Kalinoski, Matthew C. Donald, Zachary L. Mitchell, Justin F. Creeden, Terry D. Hinds   +6 more
doaj   +2 more sources

Deep-tissue high-sensitivity multimodal imaging and optogenetic manipulation enabled by biliverdin reductase knockout

Nature Communications
Performance of near-infrared probes and optogenetic tools derived from bacterial phytochromes is limited by availability of their biliverdin chromophore.
Ludmila A. Kasatkina, Chenshuo Ma, Huaxin Sheng, Matthew Lowerison, Luca Menozzi, Mikhail Baloban, Yuqi Tang, Yirui Xu, Lucas Humayun, Tri Vu, Pengfei Song, Junjie Yao, Vladislav V. Verkhusha   +12 more
doaj   +2 more sources

The Heme Oxygenase/Biliverdin Reductase System and Its Genetic Variants in Physiology and Diseases [PDF]

Antioxidants
Heme oxygenase (HO) metabolizes heme into ferrous iron, carbon monoxide (CO), and biliverdin-IXα (BV), the latter being reduced into bilirubin-IXα (BR) by the biliverdin reductase-A (BVR).
Cesare Mancuso
doaj   +2 more sources

Biliverdin reductase in cardiovascular inflammation [PDF]

, 2011
Biliverdin Reductase (BVR) functions downstream of Heme Oxygenase 1 (HO-1) in the process of heme degradation and catalyses the reduction of biliverdin to bilirubin.
Sangha, Jason
core   +7 more sources