Results 41 to 50 of about 118,565,731 (151)

Biliverdin Reductase inhibitors did not improve severe unconjugated hyperbilirubinemia in vivo

Scientific Reports, 2017
We aimed to identify potent biliverdin reductase (BVRA) inhibitors as a novel concept for the treatment of severe unconjugated hyperbilirubinemia. 1280 FDA-approved compounds were screened in vitro for their ability to inhibit human and rat BVRA activity
Remco van Dijk, Sem J. Aronson, Dirk R. de Waart, Stan F. van de Graaf, Suzanne Duijst, Jurgen Seppen, Ronald Oude Elferink, Ulrich Beuers, Piter J. Bosma   +8 more
doaj   +1 more source

Atazanavir-induced unconjugated hyperbilirubinemia prevents vascular hyporeactivity during experimental human endotoxemia

Frontiers in Immunology, 2023
ObjectiveInflammation-induced free radical release is important in the pathogenesis of several diseases, including atherosclerosis and sepsis. Heme oxygenase (HO) breaks down heme into carbon monoxide, iron, and biliverdin.
Mirrin J. Dorresteijn, Mirrin J. Dorresteijn, Douwe Dekker, Jelle Zwaag, Suzanne Heemskerk, Suzanne Heemskerk, Hennie M.J. Roelofs, Paul Smits, Johannes G. van der Hoeven, Frank A.D.T.G. Wagener, Peter Pickkers   +10 more
doaj   +1 more source

Exercise‐specific plasma proteomic signatures in racehorses: Candidates for training adaptation and peak load monitoring

Equine Veterinary Journal, Volume 58, Issue 5, Page 1396-1412, September 2026.
Abstract Background Racehorses undergo profound physiological changes with training and competition, but current biomarkers inadequately capture the complex molecular dynamics of exercise. This study aimed to identify novel plasma biomarkers of training adaptation and peak load using high‐throughput proteomics.
Jowita Grzędzicka, Bianka Świderska, Ewa Sitkiewicz, Izabela Dąbrowska, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Chronic Exposure to Ochratoxin A Induces Metabolic Dysfunction‐Associated Steatotic Liver Disease‐Like Symptoms and Obesity With Sex‐Specific Effects in Zebrafish

Food Frontiers, Volume 7, Issue 5, September 2026.
Ochratoxin A exposure induced MASLD and obesity in a sex‐specific manner. Disruption in adipocytokine signaling pathway and vitamin D metabolism led to lipid remodeling and obesity in females. However, activation of PPAR signaling pathway and ferroptosis contributed to lipid remodeling and obesity in males.
Meng Li, Chenxi Li, Mengai He, Zhenfeng Liao, Xijiao Song, Yingqiu Mi, Hongtao Zheng, Jiayin Hou, Liezhong Chen   +8 more
wiley   +1 more source

Protocol for the assay of biliverdin by the recombinant protein HUG

, 2022
Biliverdin is a secondary metabolite of heme catabolism. It is formed by the reaction catalyzed by heme oxygenase, which converts the heme group contained in proteins, such as hemoglobin, myoglobin, cytochromes, and catalase, to biliverdin, iron (II ...
Paola Sist, Federica Tramer, Sabina Passamonti, Rocio Cardenas Perez   +3 more
core   +1 more source

Mesobiliverdin-IXα Enhances Rat Pancreatic Islet Yield and Function

Frontiers in Pharmacology, 2013
The aims of this study were to produce mesobiliverdin IXα, an analog of anti-inflammatory biliverdin IXα and to test its ability to enhance rat pancreatic islet yield for allograft transplantation into diabetic recipients.
Taihei eIto, Dong eChen, Dong eChen, Cheng-Wei T. Chang, Cheng-Wei T. Chang, Takashi eKenmochi, Tomonori eSaito, Satoshi eSuzuki, Jon Y Takemoto, Jon Y Takemoto   +9 more
doaj   +1 more source

Evolutionary insights into bilin biosynthesis: Functional characterization of pre‐PcyA enzymes

Protein Science, Volume 35, Issue 9, September 2026.
Abstract Biosynthesis of the linear tetrapyrrole phycocyanobilin (PCB) by the ferredoxin‐dependent bilin reductase (FDBR) PcyA is essential for light‐harvesting and regulatory processes in diverse photosynthetic organisms, yet its evolutionary origins are not fully understood. PcyA evolved from pre‐PcyA proteins found in diverse bacteria.
Federica Frascogna, Nathan C. Rockwell, Gunhild Layer, Nicole Frankenberg‐Dinkel   +3 more
wiley   +1 more source

Long-Term Effects of Biliverdin Reductase a Deficiency in Ugt1^−/− Mice: Impact on Redox Status and Metabolism

Antioxidants, 2021
Accumulation of neurotoxic bilirubin due to a transient neonatal or persistent inherited deficiency of bilirubin glucuronidation activity can cause irreversible brain damage and death.
Giulia Bortolussi, Xiaoxia Shi, Lysbeth ten Bloemendaal, Bhaswati Banerjee, Dirk R. De Waart, Gabriele Baj, Weiyu Chen, Ronald P. Oude Elferink, Ulrich Beuers, Coen C. Paulusma, Roland Stocker, Andrés F. Muro, Piter J. Bosma   +12 more
doaj   +1 more source

The Therapeutic Potential of H2S‐Releasing Platforms in Cardiovascular Applications

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 114, Issue 8, August 2026.
The Therapeutic Potential of H2S‐Releasing Platforms. ABSTRACT Once known as a toxic gas, hydrogen sulfide (H2S) is now making its way into many therapeutic applications. Similar to its other fellow endogenous gasotransmitters, nitric oxide and carbon monoxide, H2S is a small gas with a short half‐life, making it extremely capable of penetrating ...
Tia N. Shorter, Elizabeth J. Brisbois
wiley   +1 more source

Sarcopenia Predicts Postoperative Cognitive Impairment and Poor Surgical Outcomes in Older Adults: A Prospective Cohort Study

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Sarcopenia is a progressive skeletal muscle disorder prevalent in older adults, yet its role as a risk factor for acute postoperative cognitive decline—an early manifestation within the spectrum of perioperative neurocognitive disorders (PND)—remains underexplored.
Xingming Tang, Yuncai Gu, Li Wang, Xiaochu Wu, Yipu Ren, Shudie Zhou, Yulong Cai, Xian Du, Xun Xia, Tianyao Zhang   +9 more
wiley   +1 more source